대한치과의사협회지 (The Journal of the Korean dental association)

  • 제53권7호
  • /
  • Pages.485-499
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  • 2015
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  • 0376-4672(pISSN)
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  • 2713-7961(eISSN)
대한치과의사협회 (The Korean Dental Association)
권호 표지

지연된 의도적 재식술을 통한 치주 조직 재생 방법의 고찰

Delayed intentional replantation: new approach for periodontal regeneration and establishment of theoretical background

  • 김유경 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 김동주 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 이은웅 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 임현창 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 이중석 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 정의원 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 윤정호 (인하대학교 의과대학 치과학교실) ;
  • 김의성 (연세대학교 치과대학 보존과학교실) ;
  • 이승종 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 최성호 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소)
  • Kim, You-Kyoung (Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University) ;
  • Kim, Dong-Ju (Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University) ;
  • Lee, Eun-Ung (Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University) ;
  • Lim, Hyun-Chang (Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University) ;
  • Lee, Jung-Seok (Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University) ;
  • Jung, Ui-Won (Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University) ;
  • Yun, Jeong-Ho (Department of Dentistry, School of Medicine, Inha University) ;
  • Kim, Eui-Seong (Department of Conservative Dentistry, College of Dentistry, Yonsei University) ;
  • Lee, Seong-Jong (Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University) ;
  • Choi, Seong-Ho (Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University)
  • 투고 : 2014.06.12
  • 심사 : 2015.06.17
  • 발행 : 2015.07.01
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초록

Purpose: Delayed intentional replantation was introduced as a new alternative to treat the teeth with severe periodontal involvement. The purpose of this study was to elucidate the possibility of delayed intentional replantation and establish theoretical backgrounds. Materials and Methods: Studies were performed into the following two subjects; (1)Clinical evaluation of patients who underwent delayed intentional replantation using clinical and radiographic data. Severe periodontitis involved teeth were carefully extracted and proper time for delayed replantation was evaluated by analyzing inflammation markers (IL-6, TNF-${\alpha}$). (2) Theoretical studies for efficacy of delayed intentional replantation using (-)-Epigallocatechin-3-gallate (EGCG) for preservation of periodontal ligament cells on root surface by minimizing inflammation and treatment of inflammatory extraction sockets. Results: Meaningful success ratio and survival rate were found in delayed intentional replantation showing reduced bone loss and maintained bone level. Additionally, viability of EGCG applied periodontal ligament cells was much higher than control group. Also, EGCG promoted healing of inflammatory extraction sockets by inhibiting inflammatory cell proliferation. Conclusion: Within the limitations of this study, 1-2 weeks after extraction is an appropriate time to do delayed intentional replantation. Also, EGCG provides helpful effects on viability of periodontal ligament cells and periodontium.

키워드

과제정보

연구 과제 주관 기관 : 보건복지부

참고문헌

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