Journal of the Korean Society of Physical Medicine (대한물리의학회지)

The Korean Society of Physical Medicine (대한물리의학회)
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The Short-Term Effects of Difference Frequency of Transcutaneous Electrical Nerve Stimulation on Pain Relief using c-fos Expression in Spinal Cord with Knee Osteoarthritis Rats

  • Koo, Hyun-Mo (Department of Physical Therapy, College of Science, Kyungsung University) ;
  • Na, Sang-Su (Department of Physical Therapy, Daegu University)
  • Received : 2016.07.29
  • Accepted : 2016.08.23
  • Published : 2016.11.30
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Abstract

PURPOSE: The purpose of this study was to determine the effect of different frequencies (4Hz and 100Hz) of transcutaneous electrical nerve simulation (TENS) on pain relief using c-fos expression in the spinal cord of rat osteoarthritis to investigate the appropriate frequency for pain relief. METHODS: Total of 30 Sprague-Dawley rats was used and randomly divided 2 groups according TENS frequency and applicate the TENS during 3 period (3 days, 7 days, 10 days). The induction of osteoarthritis by 3mg monosodium iodoacetat was injected into the right knee joint of rats. Three days later, commercially available TENS unit was used for stimulation was set to 20minutes on 3, 7, 10 days after surgery. Western blot analysis system was used to detect immunoreactive proteins. The thickness of the bands were photographically measured by Scion Image. RESULTS: When investigating the c-fos expression of TENS on spinal cord in OA knee over 10 days, between-groups differences in c-fos expression reached a significant level by day 10. For within-groups comparisons, the c-fos expression decreased significantly across days in low- and high-frequency TENS groups. CONCLUSION: Whether at low- and high-frequency, the TENS as a therapy obtained beneficial effects of pain relief and TNES at high-frequency is more beneficial effects on the pain relief when TENS applied at injury site.

Keywords

References

  1. Andersson S, Holmgren E, Roos A. Analgesic effects of peripheral conditioning stimulation-II. Importance of certain stimulation parameters. Acupunct Electrother Res. 1977;2(3-4):237-46. https://doi.org/10.3727/036012977817553385
  2. Beaudry H, Dubois DGL. Activation of spinal $\mu$-and ${\delta}$-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli. J Neurosci. 2011;31(37):13068-77. https://doi.org/10.1523/JNEUROSCI.1817-11.2011
  3. Duggan A, Hall JP. Enkephalins and dorsal horn neurones of the cat: effects on responses to noxious and innocuous skin stimuli. Br J Pharmacol. 1977;61(3):399-408. https://doi.org/10.1111/j.1476-5381.1977.tb08432.x
  4. Eriksson MB, Sjolund BH, Sundbarg G. Pain relief from peripheral conditioning stimulation in patients with chronic facial pain. J Neurosurg. 1984;61(1):149-55. https://doi.org/10.3171/jns.1984.61.1.0149
  5. Garrison DW, Foreman RD. Decreased activity of spontaneous and noxiously evoked dorsal horn cells during transcutaneous electrical nerve stimulation (TENS). Pain. 1994;58(3):309-15. https://doi.org/10.1016/0304-3959(94)90124-4
  6. Han J, Chen X, Sun S, et al. Effect of low-and high-frequency TENS on Met-enkephalin-Arg-Phe and dynorphin A immunoreactivity in human lumbar CSF. Pain. 1991;47(3):295-8. https://doi.org/10.1016/0304-3959(91)90218-M
  7. Hinman RS, Bennell KL, Metcalf BR, et al. Delayed onset of quadriceps activity and altered knee joint kinematics during stair stepping in individuals with knee osteoarthritis. Arch Phys Med Rehabil. 2002;83(8):1080-6. https://doi.org/10.1053/apmr.2002.33068
  8. Hinton R, Moody RL, Davis AW, et al. Osteoarthritis: diagnosis and therapeutic considerations. Am Fam Physician. 2002;65(5):841-8.
  9. Hossaini M, Duraku LS, Kohli SK, et al. Spinal distribution of c-Fos activated neurons expressing enkephalin in acute and chronic pain models. Brain Res. 2014;1543:83-92. https://doi.org/10.1016/j.brainres.2013.10.044
  10. Imamura M, Imamura ST, Kaziyama HH, et al. Impact of nervous system hyperalgesia on pain, disability, and quality of life in patients with knee osteoarthritis: a controlled analysis. Arthritis Care Res (Hoboken). 2008;59(10):1424-31. https://doi.org/10.1002/art.24120
  11. Jekal SJ, Kwon PS, Kim JK, et al. Effect of 840 nm Light-Emitting Diode (LED) Irradiation on Monosodium Iodoacetate-Induced Osteoarthritis in Rats. J Korean Soc Phys Med. 2014;9(2):151-9. https://doi.org/10.13066/kspm.2014.9.2.151
  12. Jensen H, Zesler R, Christensen T. Transcutaneous electrical nerve stimulation (TNS) for painful osteoarthrosis of the knee. Int J Rehabil Res. 1991;14(4):356-58. https://doi.org/10.1097/00004356-199112000-00013
  13. King EW, Sluka KA. The effect of varying frequency and intensity of transcutaneous electrical nerve stimulation on secondary mechanical hyperalgesia in an animal model of inflammation. J Pain. 2001;2(2):128-33. https://doi.org/10.1054/jpai.2001.19963
  14. Klein T, Magerl W, Hopf HC, et al. Perceptual correlates of nociceptive long-term potentiation and long-term depression in humans. J Neurosci. 2004;24(4):964-71. https://doi.org/10.1523/JNEUROSCI.1222-03.2004
  15. Law P, Cheing G. Optimal stimulation frequency of transcutaneous electrical nerve stimulation on people with knee osteoarthritis. J Rehabil Med. 2004;36(5):220-5. https://doi.org/10.1080/16501970410029834
  16. Lee KH, Chung JM, Willis Jr WD. Inhibition of primate spinothalamic tract cells by TENS. J Neurosurg. 1985;62(2):276-87. https://doi.org/10.3171/jns.1985.62.2.0276
  17. Lee SH, Song CH. The Effects of Transcutaneous Electrical Nerve Stimulation (TENS) on the Neuropathic Pain in Peripheral Nerve Injury. J Korean Soc Phys Med. 2013;8(1):79-89. https://doi.org/10.13066/kspm.2013.8.1.079
  18. Prita G, Kathleen AS. Effect of varying frequency, intensity, and pluse duration of transcutaneous electrical nerve simulation on primary hyperalgesia in inflamed rats. Arch Phys Med Rehabil. 2000;81:984-90. https://doi.org/10.1053/apmr.2000.5576
  19. Schadrack J, Neto F, Ableitner A, et al. Metabolic activity changes in the rat spinal cord during adjuvant monoarthritis. Neuroscience. 1999;94(2):595-605. https://doi.org/10.1016/S0306-4522(99)00186-4
  20. Sluka K, Bailey K, Bogush J, et al. Treatment with either high or low frequency TENS reduces the secondary hyperalgesia observed after injection of kaolin and carrageenan into the knee joint. Pain. 1998;77(1):97-102. https://doi.org/10.1016/S0304-3959(98)00090-6
  21. Wang HB, Zhao B, Zhong YQ, et al. Coexpression of ${\delta}$-and $\mu$-opioid receptors in nociceptive sensory neurons. Proc Natl Acad Sci USA. 2010;107(29):13117-22. https://doi.org/10.1073/pnas.1008382107
  22. Willer JC, Roby A, Boulu P, et al. Comparative effects of electroacupuncture and transcutaneous nerve stimulation on the human blink reflex. Pain. 1982;14(3):267-78. https://doi.org/10.1016/0304-3959(82)90133-6
  23. Willis Jr WD, Coggeshall RE. Sensory Mechanisms of the Spinal Cord: Volume 1 Primary Afferent Neurons and the Spinal Dorsal Horn. Texas. The University of Texas Medical Branch Galveston. 2012.
  24. XiaoHong C, SuFong G, ChungGwo C, et al. Optimal conditions for eliciting maximal electroacupuncture analgesia with dense-and-disperse mode stimulation. Am J Acupunct. 1994;22(1):47-53.

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