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The effects of scanning position on evaluation of cerebral atrophy level: assessed by item response theory

  • Mahsin, Md (Department of Mathematics and Statistics, University of Calgary) ;
  • Zhao, Yinshan (MS/MRI Research Group, Department of Medicine, University of British Columbia)
  • Received : 2016.07.20
  • Accepted : 2016.11.03
  • Published : 2016.11.30

Abstract

Cerebral atrophy affects the brain and is a common feature of patients with mild cognitive impairment or Alzheimer's diseases. It is evaluated by the radiologist or reader based on patient's history, age and the space between the brain and the skull as indicated by magnetic resonance (MR) images. A total of 70 patients were scanned in the supine and prone positions before three radiologist assessed their atrophy level. This study examined the radiologist's assessment of the cerebral atrophy level using a graded response model of item response theory (IRT). A graded response model (GRM) is fitted to our data and then item-fit and person-fit statistics are evaluated to assess the fitted model. Our analysis found that the cerebral atrophy level is better discriminated by readers in the prone position because all item slopes were greater than 2 at this position, versus the supine position where all the slope parameters were less than 1. However, the thresholds are very similar for the first reader and are quite different for the second and third readers because the scanning position affects readers differently as the category threshold estimates vary considerably between the readers..

Keywords

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