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Symptom Prevalence and Related Distress in Cancer Patients Undergoing Chemotherapy

  • Thiagarajan, Muthukkumaran (Department of Clinical Oncology, Faculty of Medicine, University of Malaya) ;
  • Chan, Caryn Mei Hsien (Faculty of Health Sciences, Universiti Kebangsaan Malaysia) ;
  • Fuang, Ho Gwo (Department of Clinical Oncology, Faculty of Medicine, University of Malaya) ;
  • Beng, Tan Seng (Faculty of Health Sciences, Universiti Kebangsaan Malaysia) ;
  • Atiliyana, MA (Department of Clinical Oncology, Faculty of Medicine, University of Malaya) ;
  • Yahaya, NA (Nursing Unit, University Malaya Medical Centre)
  • 발행 : 2016.02.05

초록

Background: Much has been done to examine the psychological impact of cancer treatment, but it remains unclear to what extent anxiety and depression is related to symptom prevalence. The present study concerned the characteristics and frequency of distress as related to symptom prevalence in cancer patients undergoing chemotherapy in Malaysia. Materials and Methods: Participants were 303 consecutive adult cancer patients undergoing chemotherapy in an academic medical center. The short form Memorial Symptom Assessment Scale (MSAS-SF), which covers three domains of symptoms (global distress, physical- and psychological symptoms) was used to cross-sectionally measure symptom frequency and associated distress via self-reporting. One-way ANOVA and t-tests were used to test mean differences among MSAS-SF subscale scores. Results: Complete data were available for 303 patients. The mean number of symptoms was 14.5. The five most prevalent were fatigue, dry mouth, hair loss, drowsiness and lack of appetite. Overall, symptom burden and frequency were higher than in other published MSAS-SF studies. Higher symptom frequency was also found to be significantly related to greater distress in cancer patients undergoing chemotherapy. Conclusions: Patients undergoing chemotherapy suffer from multiple physical and psychological symptoms. Better symptom control or palliative care is needed. Greater frequency of reported symptoms may also indicate a subconscious bid by patients for care and reassurance - thus tailored intervention to manage distress should be offered.

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참고문헌

  1. Akechi T, Okuyama T, Endo C, et al (2011). Patient's perceived need and psychological distress and/or quality of life in ambulatory breast cancer patients in Japan. Psycho Oncol, 20, 497-505. https://doi.org/10.1002/pon.1757
  2. Akin S, Can G, Avdiner A, et al (2010). Quality of life, symptom experience and distress of lung cancer patients undergoing chemotherapy. Eur J Oncol Nurs, 14, 400-9. https://doi.org/10.1016/j.ejon.2010.01.003
  3. Borjeson S, Starkhammar H, Unosson M, Bertero C (2012). Common symptoms and distress experienced among patients with colorectal cancer: a qualitative part of mixed method design. Open Nurs J, 6, 100-7. https://doi.org/10.2174/1874434601206010100
  4. Breen SJ, Baravelli CM, Schofield PE, et al (2009). Is symptom burden a predictor of anxiety and depression in patients with cancer about to commence chemotherapy? Med J Aust, 190, 99-104.
  5. Chang VT, Huang SS, Feuerman M, et al (2000a). Symptom and quality of life survey of medical oncology patients at a veteran affairs medical centre: a role for symptom assessment. Cancer, 88, 1175-83. https://doi.org/10.1002/(SICI)1097-0142(20000301)88:5<1175::AID-CNCR30>3.0.CO;2-N
  6. Chang VT, Huang SS, Feuerman M, et al (2000b). Memorial symptoms assessment scale short form. Cancer, 89, 1162-71. https://doi.org/10.1002/1097-0142(20000901)89:5<1162::AID-CNCR26>3.0.CO;2-Y
  7. Cleeland CS (2007). Symptom burden: multiple symptoms and their impact as patient-reported outcomes. J Natl Cancer Inst Monogr, 37, 16-21.
  8. Cooley ME, Short TH, Moriarty HJ, et al (2003). Symptom prevalence, distress and change over time in adults receiving treatment for lung cancer. Psycho Oncol, 12(7), 694-708. https://doi.org/10.1002/pon.694
  9. Delgado-Guay M, Parsons HA, Li Z, et al (2009). Symptom distress in advanced cancer patients with anxiety and depression in the palliative care setting. Support Care Cancer, 17, 573-9. https://doi.org/10.1007/s00520-008-0529-7
  10. Ferguson RJ, Ahles TA (2003). Low neuropsychologic performance among adult cancer survivors treated with chemotherapy. Curr Neurol Neurosci Rep, 3, 215-22. https://doi.org/10.1007/s11910-003-0081-2
  11. Fitzgerald P, Lo C, Li M, Gagliese L, Zimmerman C, Rodin G (2013). The relationship between depression and physical symptom burden in advanced cancer. BMJ Support Palliat Care, 5, 381-8
  12. Heyn L, Ruland CM, Finset A (2012). Effects of an interactive tailored assessment tool on eliciting and responding to cancer patients' cues and concerns in clinical consultations with physicians and nurses. Pat Educ Counsel, 86, 158-65. https://doi.org/10.1016/j.pec.2011.04.024
  13. Huijer HA, Abboud S, Doumit M (2012). Symptom prevalence and management of cancer patients in Lebanon. J Pain Symptom Manage, 44, 386-99. https://doi.org/10.1016/j.jpainsymman.2011.10.019
  14. Illi J, Miaskowski C, Cooper B, et al (2012). Association between pro- and anti-inflammatory cytokine genes and a symptom cluster of pain, fatigue, sleep disturbance, and depression. Cytokine, 58, 437-47. https://doi.org/10.1016/j.cyto.2012.02.015
  15. Kim JE, Dodd MJ, Aouizerat BE, et al (2009). A review of prevalence and impact of multiple symptoms in oncology patients. J Pain Symptom Manage, 37, 715-36. https://doi.org/10.1016/j.jpainsymman.2008.04.018
  16. Kroenke K, Johns SA, Theobald D, Wu J, Tu W (2013). Somatic symptoms in cancer patients trajectory over 12 months and impact on functional status and disability. Support Care Cancer, 21, 765-73. https://doi.org/10.1007/s00520-012-1578-5
  17. Lobchuk MM, Degner LF (2002). Symptom experiences: perceptual accuracy between advanced stage cancer patients and family care-givers in the home care setting. J Clin Oncol, 20, 3495-507. https://doi.org/10.1200/JCO.2002.01.153
  18. Manitta V, Zordan R, Cole-Sinclair M, et al (2011). The symptom burden of patients with haematological malignancy: a crosssectional observational study. J Pain Symptom Manage, 42, 432-42. https://doi.org/10.1016/j.jpainsymman.2010.12.008
  19. Miaskowski C, Cooper BA, Melisko M, et al (2014). Disease and treatment characteristics do not predict symptom occurrence profiles in oncology outpatients receiving chemotherapy. Cancer, 120, 2371-8. https://doi.org/10.1002/cncr.28699
  20. Oh HS, So WS (2010). Systematic review and meta-analysis of the correlates of cancer related-fatigue. Evidence Based Nursing, 191-201.
  21. Petterson G, Bertero C, Unosson M, Borjeson S (2014). Symptom prevalence, frequency, severity, and distress during chemotherapy for patients with colorectal cancer. Support Care Cancer, 22, 1171-9. https://doi.org/10.1007/s00520-013-2069-z
  22. Portenoy RK, Thaler HT, Kornblith AB, et al (1994a). Symptom prevalence, characteristics and distress in a cancer population. Qual Life Res, 3, 183-9. https://doi.org/10.1007/BF00435383
  23. Portenoy RK, Kornblith AB, Wong G, et al (1994b). Prevalance, characteristics and associated symptoms. Cancer, 74, 907-15. https://doi.org/10.1002/1097-0142(19940801)74:3<907::AID-CNCR2820740318>3.0.CO;2-#
  24. Reilly CM, Bruner DW, Mitchell, et al (2013). A literature synthesis of symptom prevalence and severity in persons receiving active cancer treatment. Support Care Cancer, 21, 1525-50. https://doi.org/10.1007/s00520-012-1688-0
  25. Rhodes VA, Watson PM (1987). Symptom distress - the concept: Past and present. Seminars Oncol Nurs, 3, 242-7. https://doi.org/10.1016/S0749-2081(87)80014-1
  26. Stasi R, Abriani L, Baccaglia P, et al (2003). Cancer-related fatigue: Evolving concepts in evaluation and treatment. Cancer, 98, 1786-801. https://doi.org/10.1002/cncr.11742
  27. Sun CC, Bodurka DC, Weaver CB, et al (2005). Rankings and symptom assessment of side effects of chemotherapy: insight from experienced patients with ovarian cancer. Support Care Cancer, 13, 219-27. https://doi.org/10.1007/s00520-004-0710-6
  28. Spichiger E, Muller-Frohlich C, Denhaerynck K, et al (2011). Prevalence of symptoms, with a focus on fatigue, and changes of symptoms over three months in outpatients receiving cancer chemotherapy. Swiss Medical Weekly, 141, 13303
  29. Tchekmedyian NS, Kallich J, McDermott A, et al (2003). The relationship between psychologic distress and cancer related fatigue. Cancer, 98, 198-203. https://doi.org/10.1002/cncr.11463
  30. Uitterhoeve R, Bensing J, Dilven E, et al (2009). Nurse-patient communication in cancer care: does responding to patient's cues predict patient satisfaction with communication. Psycho Oncol, 18, 1060-8. https://doi.org/10.1002/pon.1434
  31. Valentine AD, Meyers CA (2001). Cognitive and mood disturbances as causes and symptoms of fatigue in cancer patients. Cancer, 92, 1694-8. https://doi.org/10.1002/1097-0142(20010915)92:6+<1694::AID-CNCR1499>3.0.CO;2-S
  32. Walling AM, Weeks JC, Kahn KL, et al (2014). Symptom prevalence in lung and colorectal cancer patients. J Pain Symptom Manage, 49, 192-202.
  33. Yahaya NA, Subramaniam P, Bustam AZ, Taib NA (2015). Symptom experiences and coping strategies among multiethnic solid tumor patients undergoing chemotherapy in Malaysia, Asian Pac J Cancer Prev, 16, 723-30. https://doi.org/10.7314/APJCP.2015.16.2.723
  34. Zabora J, Brintzenhofe SK, Curbow B, et al (2001). The prevalence of psychological distress by cancer site. Psycho Oncol, 10, 19-28. https://doi.org/10.1002/1099-1611(200101/02)10:1<19::AID-PON501>3.0.CO;2-6

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