DOI QR코드

DOI QR Code

Loperamide로 유도된 변비모델에서 Lactobacillus casei에 의해 발효된 볶은 결명자 물 추출물의 효과

Effect of Roasted Water Extract of Fermented Cassia tora L. by Lactobacillus casei on the Loperamide-Induced Constipation Model in Rats.

  • Nho, Jong Hyun (National Development Institute of Korean Medicine) ;
  • Jung, Ho Kyung (National Development Institute of Korean Medicine) ;
  • Lee, Mu Jin (National Development Institute of Korean Medicine) ;
  • Jang, Ji Hun (National Development Institute of Korean Medicine) ;
  • Sim, Mi Ok (National Development Institute of Korean Medicine) ;
  • Jung, Ja Kyun (National Development Institute of Korean Medicine) ;
  • Lee, Ki Ho (National Development Institute of Korean Medicine) ;
  • An, Byeong Kwan (National Development Institute of Korean Medicine) ;
  • Cho, Jung Hee (National Development Institute of Korean Medicine) ;
  • Jang, Min Cheol (Heanam Natural Farming Association Corporation) ;
  • Yong, Ju Hyun (Heanam Natural Farming Association Corporation) ;
  • Cho, Hyun Woo (National Development Institute of Korean Medicine)
  • 투고 : 2016.10.26
  • 심사 : 2016.12.21
  • 발행 : 2016.12.30

초록

Background: Constipation is one of the most common functional gastrointestinal disorder. The present study examined the ability of water extract of fermented (FRC) and non-fermented (NFRC) roasted Cassia tora to improve intestinal function and reduce constipation in a rat constipation model. Methods and Results: Different concentration of FRC and NFRC were orally administered loperamide (5 mg/kg; LOP) reduced the number, weight, and water content of feces, as well as intestinal transit motility. However, 24 h-(24 hour fermented roasted-Cassia tora) 300 mg/kg FRC administration increased the number, weight, and water concent of feces, compared to that seen in the LOP group, and also improve intestinal transit mitility and, the thickness of distal colon and mucous fluid. Conclusions: The results of the present study indicated that LOP-induced constipation was improved by treatment with FRC. Therefore FRC could be used to develop functional foods or natural medicine for constipation. However, further study is needed to clarify how fermentation improves the medicinal properties of roasted C. tora.

키워드

참고문헌

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