십전대보탕의 장기보관 중 품질변화

Quality Variation of Sibjeondaebotang according to Long-term Storage

  • 김애경 (서울시보건환경연구원) ;
  • 이춘영 (서울시보건환경연구원) ;
  • 황광호 (서울시보건환경연구원) ;
  • 이영종 (가천대학교 한의과대학) ;
  • 김수진 (서울시보건환경연구원) ;
  • 이영주 (서울시보건환경연구원) ;
  • 이현경 (서울시보건환경연구원) ;
  • 이새람 (서울시보건환경연구원) ;
  • 김일영 (서울시보건환경연구원) ;
  • 이정미 (서울시보건환경연구원) ;
  • 유인실 (서울시보건환경연구원) ;
  • 정권 (서울시보건환경연구원)
  • Kim, Ae-kyung (Seoul Metropolitan Government Research Institute of Public Health and Enviroment) ;
  • Lee, Chun-yeong (Seoul Metropolitan Government Research Institute of Public Health and Enviroment) ;
  • Hwang, Kwang-ho (Seoul Metropolitan Government Research Institute of Public Health and Enviroment) ;
  • Lee, Young-jong (Department of Herbology, College of Oriental Medicine, Gachon University) ;
  • Kim, Su-jin (Seoul Metropolitan Government Research Institute of Public Health and Enviroment) ;
  • Lee, Young-ju (Seoul Metropolitan Government Research Institute of Public Health and Enviroment) ;
  • Lee, Hyun-kyung (Seoul Metropolitan Government Research Institute of Public Health and Enviroment) ;
  • Lee, Sae-ram (Seoul Metropolitan Government Research Institute of Public Health and Enviroment) ;
  • Kim, Il-young (Seoul Metropolitan Government Research Institute of Public Health and Enviroment) ;
  • Lee, Jeong-mi (Seoul Metropolitan Government Research Institute of Public Health and Enviroment) ;
  • Yu, In-sil (Seoul Metropolitan Government Research Institute of Public Health and Enviroment) ;
  • Jung, Kweon (Seoul Metropolitan Government Research Institute of Public Health and Enviroment)
  • 투고 : 2016.08.30
  • 심사 : 2016.10.13
  • 발행 : 2016.12.30

초록

The purpose of this study was to evaluate of quality variation of Sibujeondaebotang according to storage period and temperature (5 and $25^{\circ}C$) Identificaion test, pH, specific gravity, heavy metal, microbial limit test and glycyrrhizic acid, paeoniflorin content of Sibjeondaebotang were performed during 12 months. The significant change was not shown on identificaion test, specific gravity, microbial limit test under long term storage and the result suited a safe level standards of 'Korean National Standard of Traditional Medicinal (Herbal and Botanical) Materials - "Sibjeondaebotang"'. The test of pH showed meaningful changes between two storage temperature (5 and $25^{\circ}C$) according to increasing storage period. The contents of glycyrrhizic acid and paeoniflorin had no relation with storage temperature($5^{\circ}C$, $25^{\circ}C$) but it showed a tendency to decrease according to the length of storage period. We predicted shelf-life of glycyrrhizic acid and paeoniflorin at storgae temperature(5 and $25^{\circ}C$) as about 6 and 3 months, respecttively. Therefore considering glycyrrhizic acid and paeoniflorin, sibjeondaebotang is determined to be in good condition within 3 months, regardless of the room temperature and refrigerated temperature. We were expected to serve as a basis for the guideline of medication counseling sibjeondaebotang.

키워드

참고문헌

  1. Seo, C. S., Shin, H. K. and Shin, K. S. (2011) Monitoring on microbial flora of herbal powder in long term preservation. Kor. J. Oriental Medical Prescription 19: 83-92.
  2. 이종태 (2006) 한국인의 한약재 복용실태 조사 연구, 91. 서울식품의약품안전청, 서울.
  3. Kim, J. H., Seo C. S., Jeon, W. Y and Shin, H. K. (2012) The compositional differences of sipjeondaebo-tang(siquandabetang) decoctions extracted by diffenent extraction method and extraction time. J. Oriental Obstetrics & Gynecology 25: 108-119.
  4. 신재용 (1989) 방약합편 해설, 39. 성보사, 경기도.
  5. Lee, K.G., Huang, D. S., Yu, Y. B., Ma, J. Y., Ha, H. K. and Shin, H. K. (2006) A study on compositions, dosages and usages of sagunjatang, samultang, salmultang, sipjeondaebotang in literature. J. Kor. Medical Classic 19: 219-225.
  6. Seo, C. S., Kim, J. H., Lim, S. H. and Shin., H. K. (2012) Establishment of shelf-life ssanghwa-tang by long-term storage test. Kor. J. Pharmacogn 43: 257-264.
  7. 식품의약품안전처 (2014) 대한민국약전외한약(생약)규격집, 389. 오송.
  8. 식품의약품안전처 (2013) 대한민국약전 제 11개정, 2112-2121. 신일서적(주), 서울
  9. Kim, J. S., Hwang, S. W., Kim, J. M. and Ma, J. Y. (2001) Monitoring research for heavy metals as endocrine disruptors in sibjeondaebotang and its ingredients herbal medicines(II). Kor. J. Yakhak Hoeji 45: 448-454
  10. Seo, C. S., Kim, J. H., Lim, S. H. and Shin, H. K. (2012) Evaluation of shelf-life bojungikgi-tang by long-term storage test. Kor. J. Pharmacogn 44: 200-208.
  11. Seo, C. S., Kim, J. H., Lim, S. H. and Shin, H. K. (2011) Estimation of shelf-life by long-term storage test of pyungwi-san. J. Oriental Medical Prescription 19: 183-194.