Journal of Korean Medicine for Obesity Research (한방비만학회지)

The Society of Korean Medicine for obesity Research (한방비만학회)
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Effects of Spagranii Rhizoma Extract on High Fat·High Sucrose Diet and Streptozotocin Administration-Induced Diabetic Rats

고지방·고탄수화물 식이와 Streptozotocin-유도 당뇨병 흰쥐에서 삼릉추출물의 개선효능 연구

  • Kang, An Na (Department of Herbology, College of Korean Medicine, Dongguk University) ;
  • Kang, Seok Yong (Department of Herbology, College of Korean Medicine, Dongguk University) ;
  • Song, Mi-Young (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dongguk University) ;
  • Park, Yong-Ki (Department of Herbology, College of Korean Medicine, Dongguk University)
  • 강안나 (동국대학교 한의과대학 본초학교실) ;
  • 강석용 (동국대학교 한의과대학 본초학교실) ;
  • 송미영 (동국대학교 한의과대학 한방재활의학교실) ;
  • 박용기 (동국대학교 한의과대학 본초학교실)
  • Received : 2016.11.17
  • Accepted : 2016.11.29
  • Published : 2016.12.30
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Abstract

Objectives: This study was designed to evaluate the anti-diabetic effects of Spargaium stoloniferum Buchanan-Hamilton (Sparganii Rhizoma, SR) extract on diabetic rats. Methods: Diabetes was induced with Sprague-Dawley rats by high fat/high sucrose (HF/HS) diet for 4 weeks and injection of a single low dose of streptozotocin (STZ; 35 mg/kg). SR water extract at 500 mg/kg was orally administrated once a day for 4 weeks. Body weights, food and water intakes and urine volumes were measured. The levels of glucose, insulin, total cholesterol, glutamic oxaloacetic transaminase and glutamic-pyruvic transaminase (GPT) were measured in the sera of rats. Histological changes were observed in pancreas, liver, and kidney tissues by H&E staining. Results: The administration of Sparganii Rhizoma extract at 500 mg/kg in diabetic rats did not shown a significant difference in body weight changes and GPT levels, but showed meaningful changes in an increase of urination volume, and decrease of serum glucose and insulin levels. Total cholesterol and GPT levels were also significantly decreased after SR extract administration in diabetic rats. Furthermore, the abnormal changes of pancreas, liver and kidney were also improved by Sparganii Rhizoma extract administration. Conclusions: These results indicate that SR extract can improve HF/HS-diet and STZ-induced diabetic damages in rats through inhibition of the blood glucose and insulin increase.

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References

  1. Kharroubi AT, Darwish HM. Diabetes mellitus: the epidemic of the century. World J Diabetes. 2015 ; 6(6) : 850-7. https://doi.org/10.4239/wjd.v6.i6.850
  2. Bastaki A. Diabetes mellitus and its treatment. Int J Diabetes Metab. 2005 ; 13(3) : 111.
  3. Endocrinology College of Medicine Catholic University. Textbook of diabetes. 3. Seoul : Endocrinology College of Medicine Catholic University. 2005 : 263-431.
  4. Amos A, McCarty D, Zimmet P. The rising global burden of diabetes and its complications, estimates and projections to the year 2010. Diabetic Med. 1997 ; 14(5) : S1-85.
  5. Hong WS. Hwang-Je-Nae-Gyeong-So-Moon. Seoul : Publisher of oriental medicine. 1981 : 18, 138, 145, 163, 179, 180, 238, 249, 257, 263, 269, 274, 297, 299, 301, 304.
  6. Jung HS, Yu JS, Song BY. Recent research trends in Korean Medicine treatment of diabetes mellitus. J Pharmacopunct. 2008 ; 11(4) : 65-77. https://doi.org/10.3831/KPI.2008.11.4.065
  7. Herbology. Textbook compilation committee of college of Korean medicine. Seoul : Younglim. 1991 : 148-9.
  8. Yook CS. Studies on active substance in the crude drugs used for blood stasis and blood coagulation. Ball KH Pharma Sci .1992 ; 20 : 59-62.
  9. Tennakoon TMSG, Abeysekera AM, De silva KTD, Padumadasa C, Wijesundara DSA. Essential oil composition of Platostoma menthoides (L.) AJ paton whole plant. J Essent Oil Bear Plants. 2016 ; 19(6) : 1-5. https://doi.org/10.1080/0972060X.2014.935033
  10. Yoo GS, Lee JM, Lee CH, Jang JB, Lee KS. Study of apoptosis by scirpi tuber in Hela cell and MCF-7 cell. J Orient Obstet Gynecol. 2011 ; 24(3) : 1-13.
  11. Park KM, Cho SH, Jeong KA. Anti-proliferative effect of Sam-nueng (Sparganii Rhizoma) extract on MCF-7 cells. J Orient Obstet Gynecol. 2006 ; 19(1) : 166-77.
  12. Sun J, Wang S, Wei YH. Reproductive toxicity of Rhizoma Sparganii (Sparganium stoloniferum Buch.-Ham.) in mice: mechanisms of anti-angiogenesis and anti-estrogen pharmacologic activities. J Ethnopharmacol. 2011 ; 137(3) : 1498-503. https://doi.org/10.1016/j.jep.2011.08.026
  13. Kim JG, Kang YM, Um KS, Ko YM, Kimg TY. Antioxidative activity and antimicrobial activity of extracts from medicinal plants (Akebia quinate Decaisn, Scirusfluviatilis A. Gray, Gardenia jasminoides for grandiflora Makino). Jinju : Institute of Agriculture & Life Sciences, Gyeongsang National University. 2003 ; 37(4) : 69-75.
  14. Irondi EA, Oboh G, Akindahunsi AA. Antidiabetic effects of Mangifera indica Kernel flour-upplemented diet in streptozotocin- nduced type 2 diabetes in rats. Food Sci Nutr. 2016.
  15. Srinivasan K, Viswanad B, Asrat L, Kaul CL, Ramarao P. Combination of high-fat diet-fed and low-dose streptozotocintreated rat: a model for type 2 diabetes and pharmacological screening. Pharmacol Res. 2005 ; 52(4) : 313-20. https://doi.org/10.1016/j.phrs.2005.05.004
  16. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. $\beta$-cell deficit and increased $\beta$-cell apoptosis in humans with type 2 diabetes. Diabetes. 2003 ; 52(1) : 102-10. https://doi.org/10.2337/diabetes.52.1.102
  17. Reed MJ, Meszaros K, Entes LJ, Claypool MD, Pinkett JG, Gadbois TM, et al. A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat. Metabolism. 2000 ; 49(11) : 1390-4. https://doi.org/10.1053/meta.2000.17721
  18. Rhodes CJ. Type 2 diabetes-a matter of ${\beta}$-cell life and death? Science. 2005 ; 307(5708) : 380-4. https://doi.org/10.1126/science.1104345
  19. Global report ondiabetes. Geneva : World Health Organization. 2016.
  20. Korea Centers for Disease Control and Prevention. Diabetes mellitus. Seoul : Ministry of Health, Welfare and Family Affairs, Korea Centers for Disease Control and Prevention. 2016.
  21. Scherer PE, Hill JA. Obesity, diabetes, and cardiovascoular disease a compendium. Ciroulstion Res. 2016 ; 118(11) : 1703-5.
  22. World Health Organization. Global strategy on diet, physical activity and health. Geneva : World Health Organization. 2016.
  23. Korean Diabetes Association. Diabetes melltus. Seoul : Korea-Medicine Publishing Company. 2005 : 193-4.
  24. Ju YS, Ko BS. Screening of insulin-like substances from traditional herbs of diabetes prescription in donguibogam. J Korean Soc Agric Chem Biotechnol. 2002 ; 45(1) : 47-52.
  25. Song JC, Kim SW, Chae SA, Um DM. A review on thirst disease prescrioption in sikrochanyo. J Korean Med Class. 2012 ; 25(3) : 39-49. https://doi.org/10.14369/SKMC.2012.25.3.039
  26. Cho SY, Yoo WJ, Ahn SW, Kim NI. The formation of Sogal concept and classification in Korean traditional medicine. Korean J Orient Med. 2007 ; 13(2) : 1-14.
  27. Kang SY, Park YK. Comparison of the efficacy of the herbs for upper medication on glucose tolerance induced by high fat/high sucrose feeding-induced mice. Korean J Herbol. 2014 ; 29(5) : 1-8.
  28. Han YK, Park YK. Effect of Atractylodis Rhizoma Alba water extract on streptozotocin-induced diabetes in rats. Korean J Herbol. 2011 ; 26(4) : 23-30.
  29. Chae HJ, Lee IS, Moon HY. Effects of Schizandra Cchinensis fruit extract on the hyperglycemia and hyperlipemia in streptozotocin-induced diabetic rats. KSBB J. 2011 ; 26(2) : 126-30. https://doi.org/10.7841/ksbbj.2011.26.2.126
  30. Kumar A, Kumar Bharti S, Kumar A. Type 2 diabetes mellitus: the concerned complications and target organs. Apollo Med. 2014 ; 11(3) : 161-6. https://doi.org/10.1016/j.apme.2014.01.009
  31. Adler A. Obesity and target organ damage: diabetes. Int J Obes Relat Metab Disord. 2002 ; 26(S4) : S11-4. https://doi.org/10.1038/sj.ijo.0802212
  32. Yoon JA, Son YS. Effects of fruits and stems of Opuntia ficus-indica on blood glucose and lipid metabolism in streptozotocin-induced diabetic rats. J Korean Soc Food Sci Nutr. 2009 ; 38(2) : 146-53. https://doi.org/10.3746/jkfn.2009.38.2.146
  33. Sugiyama Y, Taketomi S, Shimura Y, Ikeda H, Fujita T. Effects of pioglitazone on glucose and lipid metabolism in Wistar fatty rats. Arzneimittel-Forschung. 1990 ; 40(3) : 263-7.
  34. Savage DB, Petersen KF, Shulman GI. Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol Rev. 2007 ; 87(2) : 507-20. https://doi.org/10.1152/physrev.00024.2006

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