Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Whitening and Anti-Wrinkle Effects of Tremella Fuciformis Extracts

흰목이버섯 추출물의 미백 및 주름개선 효과

  • Lee, Kwang Ho (Central Research Institue of Hawon Pharmaceutical) ;
  • Park, Hyun Soo (Central Research Institue of Hawon Pharmaceutical) ;
  • Yoon, Il Joo (Central Research Institue of Hawon Pharmaceutical) ;
  • Shin, Young Bong (Central Research Institue of Hawon Pharmaceutical) ;
  • Baik, Young Chan (Central Research Institue of Hawon Pharmaceutical) ;
  • Kooh, Dae Ho (Central Research Institue of Hawon Pharmaceutical) ;
  • Kim, Sung Kew (Central Research Institue of Hawon Pharmaceutical) ;
  • Jung, Ho Kyung (Jeollanamdo Development Institute of Korean Traditional Medicine) ;
  • Sim, Mi Ok (Jeollanamdo Development Institute of Korean Traditional Medicine) ;
  • Cho, Hyun Woo (Jeollanamdo Development Institute of Korean Traditional Medicine) ;
  • Jung, Won Seok (Jeollanamdo Development Institute of Korean Traditional Medicine) ;
  • Kim, Myoung Seok (Central Research Institue of Hawon Pharmaceutical)
  • Received : 2015.12.21
  • Accepted : 2016.01.18
  • Published : 2016.02.28
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Abstract

Background : The white jelly mushroom (Tremella fuciformis), one of the most popular edible fungi, has medicinal properties. However, the effects of T. fuciformis in skin whitening or anti-wrinkle efficacy has not been defined to date. The aim of the present study was to investigate the effects of T. fuciformis extracts on whitening and anti-wrinkle efficacy in skin cells. Methods and Results :We prepared T. fuciformis extracts with water. The extracts ($80^{\circ}C$) contained 12.11 mg/g polyphenol and 8.54 mg/g flavonoid concentration. T. fuciformis extracts markedly decreased melanin contents and tyrosinase activity in ${\alpha}$-MSH-stimulated melanocytes (B16F10 cells). In addition, the mRNA expression of melanin formation factors, such as microphthalmia-associated transcription factor (MITF), tyrosinase-related protein-1 (TRP-1) and tyrosinase-related protein-2 (TRP-2) were significantly down-regulated in ${\alpha}$-MSH-stimulated melanocyte. Furthermore, T. fuciformis extracts increased the synthesis of type I procollagen and reduced mRNA expression of matrix metalloproteinase 1 (MMP-1) in the human dermal fibroblast (HDFn cells). These data indicated that T. fuciformis extracts induce repression of cellular melanogenesis and protect against wrinkles caused by UVB-stimulated damage. Conclusions : Thus T. fuciformis extracts could be a cosmetic candidate for skin whitening and anti-wrinkle effects.

Keywords

References

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