DOI QR코드

DOI QR Code

Secondary Hyperalgesia to Heat Stimuli Induced by Continuous Deep Pain: A Case Report

  • Park, Jun-Hyong (Department of Orofacial Pain and Oral Medicine, Wonkwang University Daejeon Dental Hospital) ;
  • Kang, Jin-Kyu (Department of Orofacial Pain and Oral Medicine, Wonkwang University Daejeon Dental Hospital) ;
  • Shim, Young-Joo (Department of Orofacial Pain and Oral Medicine, Wonkwang University Daejeon Dental Hospital)
  • Received : 2016.12.02
  • Accepted : 2016.12.15
  • Published : 2016.12.30

Abstract

Central sensitization represents a functional change of second order neuron induced by continuous deep pain input and maintained by psychosocial factors. When afferent neurons are involved with central sensitization, secondary hyperalgesia can appear. Secondary hyperalgesia is an increased sensitivity to stimulation without a local cause. Reports on secondary hyperalgesia to heat stimuli are relatively rare compared to mechanical stimuli. And there were few reports of secondary hyperalgesia to heat stimuli in the oral cavity. We presented a case of secondary hyperalgesia to heat stimuli in the gingival area induced by continuous odontogenic pain with a review of the related literature.

Keywords

References

  1. Okeson JP. Management of temporomandibular disorders and occlusion. 7th ed. St. Louis: Elsevier; 2012. pp. 39-42.
  2. Lavigne GJ, Cistulli PA, Smith MT. Sleep medicine for dentists: a practical overview. Chicago (IL): Quintessence Pub., Co.; 2009. pp. 147-150.
  3. Zahn PK, Brennan TJ. Primary and secondary hyperalgesia in a rat model for human postoperative pain. Anesthesiology 1999;90:863-872. https://doi.org/10.1097/00000542-199903000-00030
  4. Urban MO, Gebhart GF. Supraspinal contributions to hyperalgesia. Proc Natl Acad Sci U S A 1999;96:7687-7692. https://doi.org/10.1073/pnas.96.14.7687
  5. You HJ, Lei J, Sui MY, et al. Endogenous descending modulation: spatiotemporal effect of dynamic imbalance between descending facilitation and inhibition of nociception. J Physiol 2010;588:4177-4188. https://doi.org/10.1113/jphysiol.2010.196923
  6. Pedersen JL, Kehlet H. Secondary hyperalgesia to heat stimuli after burn injury in man. Pain 1998;76:377-384. https://doi.org/10.1016/S0304-3959(98)00070-0
  7. Yucel A, Andersen OK, Nielsen J, Arendt-Nielsen L. Heat hyperalgesia in humans: assessed by different stimulus temperature profiles. Eur J Pain 2002;6:357-364. https://doi.org/10.1016/S1090-3801(02)00022-8
  8. Serra J, Campero M, Ochoa J. Flare and hyperalgesia after intradermal capsaicin injection in human skin. J Neurophysiol 1998;80:2801-2810. https://doi.org/10.1152/jn.1998.80.6.2801
  9. Sluka KA, Westlund KN. Behavioral and immunohistochemical changes in an experimental arthritis model in rats. Pain 1993;55:367-377. https://doi.org/10.1016/0304-3959(93)90013-F
  10. Kincaid W, Neubert MJ, Xu M, Kim CJ, Heinricher MM. Role for medullary pain facilitating neurons in secondary thermal hyperalgesia. J Neurophysiol 2006;95:33-41. https://doi.org/10.1152/jn.00449.2005
  11. Chen J, Lariviere WR. The nociceptive and anti-nociceptive effects of bee venom injection and therapy: a double-edged sword. Prog Neurobiol 2010;92:151-183. https://doi.org/10.1016/j.pneurobio.2010.06.006
  12. Sumikura H, Andersen OK, Drewes AM, Arendt-Nielsen L. Secondary heat hyperalgesia induced by melittin in humans. Eur J Pain 2006;10:121-125. https://doi.org/10.1016/j.ejpain.2005.01.013
  13. Verne GN, Himes NC, Robinson ME, et al. Central representation of visceral and cutaneous hypersensitivity in the irritable bowel syndrome. Pain 2003;103:99-110. https://doi.org/10.1016/S0304-3959(02)00416-5
  14. Staud R, Nagel S, Robinson ME, Price DD. Enhanced central pain processing of fibromyalgia patients is maintained by muscle afferent input: a randomized, double-blind, placebo-controlled study. Pain 2009;145:96-104. https://doi.org/10.1016/j.pain.2009.05.020
  15. Pud D, Yarnitsky D, Eisenberg E, Andersen OK, Arendt-Nielsen L. Effects of cold stimulation on secondary hyperalgesia (HA) induced by capsaicin in healthy volunteers. Exp Brain Res 2006;170:22-29. https://doi.org/10.1007/s00221-005-0185-9
  16. Ali Z, Meyer RA, Campbell JN. Secondary hyperalgesia to mechanical but not heat stimuli following a capsaicin injection in hairy skin. Pain 1996;68:401-411. https://doi.org/10.1016/S0304-3959(96)03199-5
  17. Raja SN, Campbell JN, Meyer RA. Evidence for different mechanisms of primary and secondary hyperalgesia following heat injury to the glabrous skin. Brain 1984;107:1179-1188. https://doi.org/10.1093/brain/107.4.1179
  18. Chen HS, Chen J. Secondary heat, but not mechanical, hyperalgesia induced by subcutaneous injection of bee venom in the conscious rat: effect of systemic MK-801, a non-competitive NMDA receptor antagonist. Eur J Pain 2000;4:389-401. https://doi.org/10.1053/eujp.2000.0197
  19. Lu Y, Westlund KN. Gabapentin attenuates nociceptive behaviors in an acute arthritis model in rats. J Pharmacol Exp Ther 1999;290:214-219.
  20. Desantana JM, Santana-Filho VJ, Sluka KA. Modulation between high- and low-frequency transcutaneous electric nerve stimulation delays the development of analgesic tolerance in arthritic rats. Arch Phys Med Rehabil 2008;89:754-760. https://doi.org/10.1016/j.apmr.2007.11.027
  21. Okeson JP. Bell's oral and facial pain. 7th ed. Chicago (IL): Quintessence Pub., Co.; 2014. pp. 218-219.