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Reconstruction of partial maxillectomy defect with a buccal fat pad flap and application of 4-hexylresorcinol: a case report

  • Seok, Hyun (Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University) ;
  • Kim, Min-Keun (Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University) ;
  • Kim, Seong-Gon (Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University)
  • Received : 2016.06.09
  • Accepted : 2016.07.22
  • Published : 2016.12.31

Abstract

Mucoepidermoid carcinoma (MEC) is the most common type of malignant neoplasm in the minor salivary gland. The hard palate is a frequently involved site of MEC. The treatment of low-grade MEC on the hard palate is wide local resection with a tumor-free margin. In the present case, the maxillary defect was reconstructed using a buccal fat pad (BFP) flap, followed by application of 4-hexylresorcinol (4HR) ointment for 2 weeks. The grafted BFP successfully covered the tumor resection defect without tension and demonstrated complete re-epithelialization without any complications.

Keywords

References

  1. Brandwein MS, Ivanov K, Wallace DI, Hille JJ, Wang B, Fahmy A, et al. Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol 2001;25:835-45. https://doi.org/10.1097/00000478-200107000-00001
  2. Caccamese JF Jr, Ord RA. Paediatric mucoepidermoid carcinoma of the palate. Int J Oral Maxillofac Surg 2002;31:136-9. https://doi.org/10.1054/ijom.2001.0221
  3. Baumgardt C, Gunther L, Sari-Rieger A, Rustemeyer J. Mucoepidermoid carcinoma of the palate in a 5-year-old girl: case report and literature review. Oral Maxillofac Surg 2014;18:465-9. https://doi.org/10.1007/s10006-014-0461-6
  4. Kokemueller H, Brueggemann N, Swennen G, Eckardt A. Mucoepidermoid carcinoma of the salivary glands--clinical review of 42 cases. Oral Oncol 2005;41:3-10. https://doi.org/10.1016/j.oraloncology.2004.01.017
  5. Nabil S, Lo RC, Choi WS. Simultaneous radicular cyst and mucoepidermoid carcinoma in the maxilla: a diagnostic nightmare. BMJ Case Rep 2013. doi: 10.1136/bcr-2013-010290.
  6. Youn T, Lee CS, Kim HS, Lim K, Lee SJ, Kim BC, et al. Use of the pedicled buccal fat pad in the reconstruction of intraoral defects: a report of five cases. J Korean Assoc Oral Maxillofac Surg 2012;38:116-20. https://doi.org/10.5125/jkaoms.2012.38.2.116
  7. Egyedi P. Utilization of the buccal fat pad for closure of oro-antral and/or oro-nasal communications. J Maxillofac Surg 1977;5:241-4. https://doi.org/10.1016/S0301-0503(77)80117-3
  8. Yeh CJ. Application of the buccal fat pad to the surgical treatment of oral submucous fibrosis. Int J Oral Maxillofac Surg 1996;25:130-3. https://doi.org/10.1016/S0901-5027(96)80058-0
  9. Lee SW, Um IC, Kim SG, Cha MS. Evaluation of bone formation and membrane degradation in guided bone regeneration using a 4-hexylresorcinol-incorporated silk fabric membrane. Maxillofac Plast Reconstr Surg 2015;37:32. https://doi.org/10.1186/s40902-015-0034-0
  10. Kim SG, Kim AS, Jeong JH, Choi JY, Kweon H. 4-hexylresorcinol stimulates the differentiation of SCC-9 cells through the suppression of E2F2, E2F3 and Sp3 expression and the promotion of Sp1 expression. Oncol Rep 2012;28:677-81. https://doi.org/10.3892/or.2012.1845
  11. Rapidis AD, Alexandridis CA, Eleftheriadis E, Angelopoulos AP. The use of the buccal fat pad for reconstruction of oral defects: review of the literature and report of 15 cases. J Oral Maxillofac Surg 2000;58:158-63.
  12. Ahn J, Kim SG, Kim MK, Kim DW, Lee JH, Seok H, et al. Topical delivery of 4-hexylresorcinol promotes wound healing via tumor necrosis factor-$\alpha$ suppression. Burns 2016;42:1534-41. https://doi.org/10.1016/j.burns.2016.04.016
  13. Kim IK, Cho HW, Cho HY, Seo JH, Lee DH, Park SH. Facelift incision and superficial musculoaponeurotic system advancement in parotidectomy: case reports. Maxillofac Plast Reconstr Surg 2015;37:40. https://doi.org/10.1186/s40902-015-0040-2
  14. Rapidis AD, Givalos N, Gakiopoulou H, Stavrianos SD, Faratzis G, Lagogiannis GA, et al. Mucoepidermoid carcinoma of the salivary glands. Review of the literature and clinicopathological analysis of 18 patients. Oral Oncol 2007;43:130-6. https://doi.org/10.1016/j.oraloncology.2006.03.001
  15. Kim BG, Kim JH, Kim MI, Han JJ, Jung S, Kook MS, et al. Retrospective study on factors affecting the prognosis in oral cancer patients who underwent surgical treatment only. Maxillofac Plast Reconstr Surg 2016;38:3. https://doi.org/10.1186/s40902-015-0047-8
  16. Kim CM, Park MH, Yun SW, Kim JW. Treatment of pathologic fracture following postoperative radiation therapy: clinical study. Maxillofac Plast Reconstr Surg. 2015;37:31. https://doi.org/10.1186/s40902-015-0032-2
  17. Mesolella M, Iengo M, Testa D, DI Lullo AM, Salzano G, Salzano FA. Mucoepidermoid carcinoma of the base of tongue. Acta Otorhinolaryngol Ital 2015;35:58-61.
  18. Samman N, Cheung LK, Tideman H. The buccal fat pad in oral reconstruction. Int J Oral Maxillofac Surg 1993;22:2-6. https://doi.org/10.1016/S0901-5027(05)80346-7
  19. Hanazawa Y, Itoh K, Mabashi T, Sato K. Closure of oroantral communications using a pedicled buccal fat pad graft. J Oral Maxillofac Surg 1995;53:771-5; discussion 775-6. https://doi.org/10.1016/0278-2391(95)90329-1
  20. Kweon H, Kim SG, Choi JY. Inhibition of foreign body giant cell formation by 4-hexylresorcinol through suppression of diacylglycerol kinase delta gene expression. Biomaterials 2014;35:8576-84. https://doi.org/10.1016/j.biomaterials.2014.06.050

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