Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Other Gynecologic Pathology in Endometrial Cancer Patients

  • Khunnarong, Jakkapan (Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University) ;
  • Tangjitgamol, Siriwan (Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University) ;
  • Srijaipracharoen, Sunamchok (Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University)
  • Published : 2016.03.07
Download PDF
⟨ Previous Next ⟩

Abstract

Background: To evaluate the prevalence and features of other gynecologic or surgical lesions in endometrial cancer (EMC) patients. Materials and Methods: Clinico-pathological data of EMC patients who were treated in the institution from 1995 to 2012 were collected. Data collected were age, stage of disease according to the FIGO 2009 criteria (FIGO), histopathology, tumor grade, adjuvant therapy, other gynecologic or surgical lesions, follow-up period, and living status. Results: The mean age of 396 patients was $56.7{\pm}10.64years$. Abnormal uterine bleeding was the most common presenting symptom (90.1%). Bleeding was accompanied with pelvic mass in 7.7% and 5.4% had only a pelvic mass. Abnormal cervical cytology was found in 3.8%. Approximately 75% had early stage diseases and 86% had endometrioid histology. We found 55.8% of EMC patients had other gynecologic lesions: 89.6% benign and 9.5% malignant. Some 4.5% had pre-invasive cervical/vulva/vagina lesions. The two most common gynecologic lesions were myoma uteri and ovarian tumors. Focusing on the latter, approximately 14% were benign while 8% were malignant. Among 364 patients with available data, surgical lesions were found in 11.8%, 5.7% benign and 9.2% malignant. The most common benign surgical condition was chronic appendicitis while breast and colon cancers were the two most common malignant lesions found. Conclusions: More than half of EMC patients had other gynecologic lesions including benign and malignant tumors. Surgical lesions were also found in more than one-tenth of patients. Careful pre-operative evaluation and intra-operative inspection are advised for proper management and better prognosis.

Keywords

References

  1. Andersen J (1996). Growth factors and cytokines in uterine leiomyomas. Semin Reprod Endocrinol, 14, 269-82. https://doi.org/10.1055/s-2007-1016336
  2. Barakat RR, Park RC, Grigsby PW, et al (1997). Corpus:epithelial tumors. In: Hoskins WJ, Perez CA, Young RC, editors. Principles and practice of gynecologic oncology. 2nd ed. Philadelphia: Lippincott-Raven, 859-96.
  3. Barnes MN, Kilgore LC (2000). Complete surgical staging of early endometrial adenocarcinoma: optimizing patient outcomes. Semin Radiat Oncol, 10, 3-7. https://doi.org/10.1016/S1053-4296(00)80014-4
  4. Binesh F, Akhavan A, Behniafard N, et al (2014). Endometrial adenocarcinoma: clinicopathologic and survival characteristics in Yazd, Iran. Asian Pac J Cancer Prev, 15, 2797-801. https://doi.org/10.7314/APJCP.2014.15.6.2797
  5. Chan JK, Sherman AE, Kapp DS, et al (2011). Influence of gynecologic oncologists on the survival of patients with endometrial cancer. J Clin Oncol, 29, 832-8. https://doi.org/10.1200/JCO.2010.31.2124
  6. Ferlay J, Soerjomataram I, Ervik M, et al (2013). GLOBOCAN 2012 v1.0, Cancer. Incidence and Mortality Worldwide: IARC Cancer Base No. 11 [Internet]. Lyon, france: international agency for research on cancer.
  7. Fortuny J, Sima C, Bayuga S, et al (2009). Risk of endometrial cancer in relation to medical conditions and medication use. Cancer Epidemiol Biomarkers Prev, 18, 1448-56. https://doi.org/10.1158/1055-9965.EPI-08-0936
  8. Horwitz RI, Horwitz SM, Feinstein R, et al (1981). Necropsy diagnosis of endometrial cancer and detection-bias in case/control studies. Lancet, 2, 66-8.
  9. Howlader N, Noone AM, Krapcho M, et al (2013). SEER cancer statistics review, 1975-2011 based on November 2013 SEER data submission. National Cancer Institute. Bethesda, MD.
  10. Koss L, Schreiber K, Oberlander S, et al (1981). Screening of asymptomatic women for endometrial cancer. CA Cancer J Clin, 31, 300-17. https://doi.org/10.3322/canjclin.31.5.300
  11. Lim YK, Padma R, Foo L, et al (2011). Survival outcome of women with synchronous cancers of endometrium and ovary: a 10 year retrospective cohort study. J Gynecol Oncol, 22, 239-43. https://doi.org/10.3802/jgo.2011.22.4.239
  12. Manchana T, Khemapech N (2008). Endometrial adenocarcinoma in young Thai women. Asian Pac J Cancer Prev, 9, 283-6.
  13. Ouldamer L, Rossard L, Arbion F, et al (2014). Risk of incidental finding of endometrial cancer at the time of hysterectomy for benign condition. J Minim Inv Gynecol, 21, 131-5. https://doi.org/10.1016/j.jmig.2013.08.002
  14. Rein MS, Barbieri RL, Friedman AJ (1995). Progesterone: a critical role in the pathogenesis of uterine myomas. Am J Obstet Gynecol, 172, 14-8. https://doi.org/10.1016/0002-9378(95)90077-2
  15. Smith-Bindman R, Kerlikowske K, Feldstein V, et al (1998). Endovaginal ultrasound to exclude endometrial cancer and other endometrial abnormalities. JAMA, 280, 1510-7.
  16. Srisomboon J, Phongnarisorn C, Suprasert P (2001). Endometrial cancer diagnosed in patients undergoing hysterectomy for benign gynecologic conditions. Thai J Obstet Gynaecol, 13, 29-32.
  17. Tangjitgamol S, Manusirivithaya S, Srijaipracharoen S, et al (2010). Endometrial cancer in thai women: clinicopathological presentation and survival. Asian Pacific J Cancer Prev, 11, 1267-72.
  18. Zaino R, Whitney C, Brady MF, et al (2001). Simultaneously detected endometrial and ovarian carcinomas: a prospective clinicopathologic study of 74 cases: a gynecologic oncology group study. Gynecol Oncol, 83, 355-62. https://doi.org/10.1006/gyno.2001.6400
  19. Zimmermann A, Bernuit D, Gerlinger C, et al (2012). Prevalence, symptoms and management of uterine fibroids: an international internet-based survey of 21,746 women. BMC Women's Health, 12, 6. https://doi.org/10.1186/1472-6874-12-6

Cited by

  1. Association of Endometrial Cancer Risk With Postmenopausal Bleeding in Women vol.178, pp.9, 2018, https://doi.org/10.1001/jamainternmed.2018.2820