Journal of Oral Medicine and Pain

  • 제41권1호
  • /
  • Pages.21-25
  • /
  • 2016
  • /
  • 2288-9272(pISSN)
  • /
  • 2383-8493(eISSN)
대한안면통증구강내과학회 (Korean Academy of Orofacial Pain and Oral Medicine)
권호 표지
DOI QR코드

DOI QR Code

Retrospective Review of Effectiveness of Various Pharmacological Agents in Treating Burning Mouth Syndrome

  • Im, Yeong-Gwan (Department of Oral Medicine, Chonnam National University Dental Hospital) ;
  • Kim, Byung-Gook (Department of Oral Medicine, School of Dentistry, Chonnam National University) ;
  • Kim, Jae-Hyung (Department of Oral Medicine, School of Dentistry, Chonnam National University)
  • 투고 : 2016.02.26
  • 심사 : 2016.03.17
  • 발행 : 2016.03.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Purpose: Burning mouth syndrome (BMS) is a chronic pain condition involving the oral and perioral regions, often characterized by a burning sensation and pain in elderly patients. In this study, we investigated the effectiveness of pharmacological agents for the treatment of BMS patients through a retrospective chart review. Methods: We enrolled 61 BMS subjects (57 females, 4 males; $66.4{\pm}10.9$ years of age) from among consecutive patients treated pharmacologically from January 2014 to June 2015 at Chonnam National University Dental Hospital. Patients with secondary BMS associated with local factors were excluded. The treatment period, number of pharmacological agents tried, and effectiveness of the drugs administered to each subject were analyzed. Results: The mean treatment period for the management of BMS was 2.5 months. More than three agents were tried to control BMS symptoms in 17 subjects (27.9%); two agents were used in 10 subjects (16.4%), and a single agent in 24 subjects (39.3%). Clonazepam was prescribed most frequently and was effective at relieving symptoms in 30 of 39 subjects (76.9%). Paroxetine was moderately effective, relieving symptoms in 7 of 17 subjects (41.2%). Some of the subjects benefited from tricyclic antidepressants, gabapentin, and lipoic acid. A topical local anesthetic used to supplement other systemic agents had ameliorating effects in four of six subjects. Conclusions: Within the study limitations, clonazepam was the most effective drug and antidepressants were efficacious in some subjects for relieving the symptoms of BMS. These pharmacological agents could be considered as first-line drugs for the management of BMS.

키워드

참고문헌

  1. Bergdahl M, Bergdahl J. Burning mouth syndrome: prevalence and associated factors. J Oral Pathol Med 1999;28:350-354.
  2. Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders: 2nd edition. Cephalalgia 2004;24(Suppl 1):9-160. https://doi.org/10.1111/j.1468-2982.2003.00824.x
  3. Scala A, Checchi L, Montevecchi M, Marini I, Giamberardino MA. Update on burning mouth syndrome: overview and patient management. Crit Rev Oral Biol Med 2003;14:275-291. https://doi.org/10.1177/154411130301400405
  4. Clark G, Dionne R. Orofacial pain: a guide to medications and management. Chichester: John Wiley & Sons; 2012. pp. 240-243.
  5. Sardella A, Lodi G, Demarosi F, Bez C, Cassano S, Carrassi A. Burning mouth syndrome: a retrospective study investigating spontaneous remission and response to treatments. Oral Dis 2006;12:152-155. https://doi.org/10.1111/j.1601-0825.2005.01174.x
  6. Rodriguez-de Rivera-Campillo E, Lopez-Lopez J. Evaluation of the response to treatment and clinical evolution in patients with burning mouth syndrome. Med Oral Patol Oral Cir Bucal 2013;18:e403-e410.
  7. Barker KE, Batstone MD, Savage NW. Comparison of treatment modalities in burning mouth syndrome. Aust Dent J 2009;54:300-305. https://doi.org/10.1111/j.1834-7819.2009.01154.x
  8. Min BK, Jung JK, Choi JK. Clinical features affecting the efficacy of systemic clonazepam for management of burning mouth syndrome. J Oral Med Pain 2012;37:161-167. https://doi.org/10.14476/jomp.2012.37.3.161
  9. Gremeau-Richard C, Woda A, Navez ML, et al. Topical clonazepam in stomatodynia: a randomised placebo-controlled study. Pain 2004;108:51-57. https://doi.org/10.1016/j.pain.2003.12.002
  10. de Moraes M, do Amaral Bezerra BA, da Rocha Neto PC, de Oliveira Soares AC, Pinto LP, de Lisboa Lopes Costa A. Randomized trials for the treatment of burning mouth syndrome: an evidence-based review of the literature. J Oral Pathol Med 2012;41:281-287. https://doi.org/10.1111/j.1600-0714.2011.01100.x
  11. Yamazaki Y, Hata H, Kitamori S, Onodera M, Kitagawa Y. An open-label, noncomparative, dose escalation pilot study of the effect of paroxetine in treatment of burning mouth syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;107:e6-e11. https://doi.org/10.1016/j.tripleo.2008.08.024
  12. Maina G, Vitalucci A, Gandolfo S, Bogetto F. Comparative efficacy of SSRIs and amisulpride in burning mouth syndrome: a single-blind study. J Clin Psychiatry 2002;63:38-43. https://doi.org/10.4088/JCP.v63n0108
  13. Femiano F, Scully C. Burning mouth syndrome (BMS): double blind controlled study of alpha-lipoic acid (thioctic acid) therapy. J Oral Pathol Med 2002;31:267-269. https://doi.org/10.1034/j.1600-0714.2002.310503.x
  14. Palacios-Sanchez B, Moreno-Lopez LA, Cerero-Lapiedra R, Llamas-Martinez S, Esparza-Gomez G. Alpha lipoic acid efficacy in burning mouth syndrome: a controlled clinical trial. Med Oral Patol Oral Cir Bucal 2015;20:e435-e440.
  15. Lopez-Jornet P, Camacho-Alonso F, Leon-Espinosa S. Efficacy of alpha lipoic acid in burning mouth syndrome: a randomized, placebo-treatment study. J Oral Rehabil 2009;36:52-57. https://doi.org/10.1111/j.1365-2842.2008.01914.x
  16. Carbone M, Pentenero M, Carrozzo M, Ippolito A, Gandolfo S. Lack of efficacy of alpha-lipoic acid in burning mouth syndrome: a double-blind, randomized, placebo-controlled study. Eur J Pain 2009;13:492-496. https://doi.org/10.1016/j.ejpain.2008.06.004
  17. Cavalcanti DR, da Silveira FR. Alpha lipoic acid in burning mouth syndrome: a randomized double-blind placebo-controlled trial. J Oral Pathol Med 2009;38:254-261. https://doi.org/10.1111/j.1600-0714.2008.00735.x
  18. Ito M, Tokura T, Yoshida K, et al. Five patients with burning mouth syndrome in whom an antidepressant (serotonin-noradrenaline reuptake inhibitor) was not effective, but pregabalin markedly relieved pain. Clin Neuropharmacol 2015;38:158-161. https://doi.org/10.1097/WNF.0000000000000093
  19. Siniscalchi A, Gallelli L, Marigliano NM, Orlando P, De Sarro G. Use of topiramate for glossodynia. Pain Med 2007;8:531-534. https://doi.org/10.1111/j.1526-4637.2006.00152.x
  20. Kim YD, Lee JH, Shim JH. Duloxetine in the treatment of burning mouth syndrome refractory to conventional treatment: a case report. J Int Med Res 2014;42:879-883. https://doi.org/10.1177/0300060514527913
  21. Stuginski-Barbosa J, Rodrigues GG, Bigal ME, Speciali JG. Burning mouth syndrome responsive to pramipexol. J Headache Pain 2008;9:43-45. https://doi.org/10.1007/s10194-008-0003-4
  22. Gick CL, Mirowski GW, Kennedy JS, Bymaster FP. Treatment of glossodynia with olanzapine. J Am Acad Dermatol 2004;51:463-465. https://doi.org/10.1016/j.jaad.2004.02.016
  23. Ueda N, Kodama Y, Hori H, et al. Two cases of burning mouth syndrome treated with olanzapine. Psychiatry Clin Neurosci 2008;62:359-361. https://doi.org/10.1111/j.1440-1819.2008.01806.x
  24. Apter JT, Allen LA. Buspirone: future directions. J Clin Psychopharmacol 1999;19:86-93. https://doi.org/10.1097/00004714-199902000-00014
  25. Wong H, Dockens RC, Pajor L, et al. 6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats. Drug Metab Dispos 2007;35:1387-1392. https://doi.org/10.1124/dmd.107.015768
  26. Loane C, Politis M. Buspirone: what is it all about? Brain Res 2012;1461:111-118. https://doi.org/10.1016/j.brainres.2012.04.032
  27. Bergman J, Roof RA, Furman CA, et al. Modification of cocaine self-administration by buspirone (buspar$^{(R)}$): potential involvement of D3 and D4 dopamine receptors. Int J Neuropsychopharmacol 2013;16:445-458. https://doi.org/10.1017/S1461145712000661
  28. Gray AM, Spencer PS, Sewell RD. The involvement of the opioidergic system in the antinociceptive mechanism of action of antidepressant compounds. Br J Pharmacol 1998;124:669-674. https://doi.org/10.1038/sj.bjp.0701882
  29. Benbouzid M, Gaveriaux-Ruff C, Yalcin I, et al. Delta-opioid receptors are critical for tricyclic antidepressant treatment of neuropathic allodynia. Biol Psychiatry 2008;63:633-636. https://doi.org/10.1016/j.biopsych.2007.06.016
  30. Hearn L, Derry S, Phillips T, Moore RA, Wiffen PJ. Imipramine for neuropathic pain in adults. Cochrane Database Syst Rev 2014;5:CD010769.
  31. Ni Riordain R, McCreary C. Patient-reported outcome measures in burning mouth syndrome: a review of the literature. Oral Dis 2013;19:230-235. https://doi.org/10.1111/j.1601-0825.2012.01952.x
  32. Kuten-Shorrer M, Kelley JM, Sonis ST, Treister NS. Placebo effect in burning mouth syndrome: a systematic review. Oral Dis 2014;20:e1-e6. https://doi.org/10.1111/odi.12192