Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Chemical Composition of Clausena lansium (Lour.) Skeels Leaves and Antifungal Activity

  • Received : 2015.07.02
  • Accepted : 2015.08.07
  • Published : 2016.03.31
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Abstract

The first study on chemical constituents and biological activities of Clausena lansium (Lour.) Skeels (Rutaceae) growing in Vietnam has been done. Phytochemical investigation of n-hexane extract led to the isolation of five compounds: dihydroindicolactone (1), 8-geranyloxy psoralen (2), imperatorin (3), heraclenol (4) and indicolactone (5), in which this is the first report on the presence of dihydroindicolactone (1). Their structures were elucidated based on LC/MS/NMR hyphenated techniques as well as comparison with those of literature data. The n-hexane extract and its subfractions, ethanol 95% extract and several isolated compounds were evaluated for antifungal activity.

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