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종이기반 소수성 채널에서의 효율적이고 간편한 비타민 C의 검출기술 개발

Facile and Effective Detection of Vitamin C on a Paper Based Kit

  • 황장선 (중앙대학교 창의ICT공과대학 융합공학부) ;
  • 서영민 (중앙대학교 창의ICT공과대학 융합공학부) ;
  • 최종훈 (중앙대학교 창의ICT공과대학 융합공학부)
  • Hwang, Jangsun (School of Integrative Engineering, Chung-Ang University) ;
  • Seo, Youngmin (School of Integrative Engineering, Chung-Ang University) ;
  • Choi, Jonghoon (School of Integrative Engineering, Chung-Ang University)
  • 투고 : 2016.01.19
  • 심사 : 2016.02.25
  • 발행 : 2016.03.31

초록

Recently paper based diagnostic kits have drawn great interest in the point-of-care testing market (POCT). The paper based detection systems provide inexpensive, rapid and safe analyses for disease markers and/or pathogens. Vitamin C (i.e., ascorbic acid) regulates body's immune system as an antioxidant agent. Humans, however, do not have enough amounts of enzymes involved in the synthesis of vitamin C that it is required to be obtained from their diets (e.g., beverages and/or supplements). Here, we have prepared a paper based kit to detect the concentration of Vitamin C presented in commercially available beverages. The evaluation provides the fast, simple and accurate results for detecting Vitamin C in the prepared paper based kit.

키워드

참고문헌

  1. Eggersdorfer, M., G. Adam, M. John, W. Hahnlein, L. Labler, K. U. Baldenius, L. von dem Bussche-Hunnefeld, E. Hilgemann, P. Hoppe, and R. Sturmer (1996) Vitamins, pp. 89-102. Ullmann's Encyclopedia of Industrial Chemistry.
  2. Sherman, H. C. and S. L. Smith (2013) The vitamins, pp. 271-276, Hardpress.
  3. Davies, M. B., J. Austin, and D. A. Partridge (1991) Vitamin C: Its chemistry and biochemistry, pp. 154, RSC.
  4. Kalt, W., C. F. Forney, A. Martin, and R. L. Prior (1999) Antioxidant capacity, vitamin C, phenolics, and anthocyanins after fresh storage of small fruits. J. Agric. Food. Chem. 47: 4638-4644. https://doi.org/10.1021/jf990266t
  5. Carpenter, K. J. (1988) The history of scurvy and vitamin C, pp. 198, Cambridge University Press.
  6. Duarte, T. L. and J. Lunec (2005) Review: When is an antioxidant not an antioxidant? A review of novel actions and reactions of vitamin C. Free Radical Res. 39: 671-686. https://doi.org/10.1080/10715760500104025
  7. Dehghan, M., N. Akhtar-Danesh, C. R. McMillan, and L. Thabane (2007) Is plasma vitamin C an appropriate biomarker of vitamin C intake? A systematic review and meta-analysis. Nutr. J. 6: 41. https://doi.org/10.1186/1475-2891-6-41
  8. Korea Consumer Agency. Submission of manuscript. http://www.dbpia.co.kr/Article/NODE02485240 (2013).
  9. Heo, S. H. (2007) The present condition & development for labeling and advertising system of health functional food. Food Sci. Ind. 40: 11-15.
  10. Levine, M., C. Conry-Cantilena, Y. Wang, R. W. Welch, P. W. Washko, K. R. Dhariwal, J. B. Park, A. Lazarev, J. F. Graumlich, and J. King (1996) Vitamin C pharmacokinetics in healthy volunteers: Evidence for a recommended dietary allowance. Proc. Natl. Acad. Sci. 93: 3704-3709. https://doi.org/10.1073/pnas.93.8.3704
  11. Shah, P., X. Zhu, and C. Z. Li (2013) Development of paper-based analytical kit for point-of-care testing, Expert Rev. Mol. Diagn. 13: 83-91. https://doi.org/10.1586/erm.12.130
  12. Yetisen, A. K., M. S. Akram, and C. R. Lowe (2013) Paper-based microfluidic point-of-care diagnostic devices. Lab on a Chip 13: 2210-2251. https://doi.org/10.1039/c3lc50169h
  13. Martinez, A. W., S. T. Phillips, E. Carrilho, S. W. Thomas III, H. Sindi, and G. M. Whitesides (2008) Simple telemedicine for developing regions: camera phones and paper-based microfluidic devices for real-time, off-site diagnosis. Anal. Chem. 80: 3699-3707. https://doi.org/10.1021/ac800112r
  14. Nie, Z., C. A. Nijhuis, J. Gong, X. Chen, A. Kumachev, A. W. Martinez, M. Narovlyansky, and G. M. Whitesides (2010) Electrochemical sensing in paper-based microfluidic devices. Lab on a Chip 10: 477-483. https://doi.org/10.1039/B917150A
  15. Mosadegh, B., B. E. Dabiri, M. R. Lockett, R. Derda, P. Campbell, K. K. Parker, and G. M. Whitesides (2014) Three-dimensional paper-based model for cardiac ischemia. Adv. Healthc. Mater. 3: 1036-1043. https://doi.org/10.1002/adhm.201300575
  16. Martinez, A. W., S. T. Phillips, G. M. Whitesides, and E. Carrilho (2009) Diagnostics for the developing world: microfluidic paperbased analytical devices. Anal. Chem. 82: 3-10.
  17. Carrilho, E., A. W. Martinez, and G. M. Whitesides (2009) Understanding wax printing: a simple micropatterning process for paperbased microfluidics. Anal. Chem. 81: 7091-7095. https://doi.org/10.1021/ac901071p
  18. Suntornsuk, L., W. Gritsanapun, S. Nilkamhank, and A. Paochom (2002) Quantitation of vitamin C content in herbal juice using direct titration. J. Pharm. Biomed. Anal. 28: 849-855. https://doi.org/10.1016/S0731-7085(01)00661-6