Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Protective effect of Korean Red Ginseng against chemotherapeutic drug-induced premature catagen development assessed with human hair follicle organ culture model

  • Keum, Dong In (Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine) ;
  • Pi, Long-Quan (Department of Dermatology, Yanbian University Hospital) ;
  • Hwang, Sungjoo Tommy (Dr. Hwang's Hair-Hair Clinic) ;
  • Lee, Won-Soo (Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine)
  • Received : 2015.05.20
  • Accepted : 2015.07.03
  • Published : 2016.04.15
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Abstract

Background: Chemotherapy-induced alopecia (CIA) is one of the most distressing side effects for patients undergoing chemotherapy. This study evaluated the protective effect of Korean Red Ginseng (KRG) on CIA in a well-established in vitro human hair follicle organ culture model as it occurs in vivo. Methods: We examined whether KRG can prevent premature hair follicle dystrophy in a human hair follicle organ culture model during treatment with a key cyclophosphamide metabolite, 4-hydroperoxycyclophosphamide (4-HC). Results: 4-HC inhibited human hair growth, induced premature catagen development, and inhibited proliferation and stimulated apoptosis of hair matrix keratinocytes. In addition, 4-HC increased p53 and Bax protein expression and decreased Bcl2 protein expression. Pretreatment with KRG protected against 4-HC-induced hair growth inhibition and premature catagen development. KRG also suppressed 4-HC-induced inhibition of matrix keratinocyte proliferation and stimulation of matrix keratinocyte apoptosis. Moreover, KRG restored 4-HC-induced p53 and Bax/Bcl2 expression. Conclusion: Overall, our results indicate that KRG may protect against 4-HC-induced premature catagen development through modulation of p53 and Bax/Bcl2 expression.

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References

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