Journal of the Microelectronics and Packaging Society (마이크로전자및패키징학회지)

The Korean Microelectronics and Packaging Society (한국마이크로전자및패키징학회)
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A Study on Characteristics Analysis of Multichannel Filter Module for Near-infrared Fluorescence Imaging

근적외선 형광 이미징 영상 구현을 위한 다채널 필터 모듈 특성분석 연구

  • Choi, Jinsoo (Department of Opto-Mechatronics Engineering, Pusan National University) ;
  • Cho, Sang Uk (Department of Cogno-Mechatronics Engineering, Pusan National University) ;
  • Kim, Doo-In (BK21+Nano-integrated Cognomechatronics Engineering, Pusan National University) ;
  • Lee, Hak-Guen (Nawoo Vision Corporation R&D Gropu) ;
  • Choi, Hak Soo (Department of Opto-Mechatronics Engineering, Pusan National University) ;
  • Jeong, Myung Yung (Department of Opto-Mechatronics Engineering, Pusan National University)
  • 최진수 (부산대학교 광메카트로닉스공학과) ;
  • 조상욱 (부산대학교 인지메카트로닉스공학과) ;
  • 김두인 (부산대학교 BK21+나노융합인지메카트로닉스공학 사업단) ;
  • 이학근 (나우비젼 기술연구소) ;
  • 최학수 (부산대학교 광메카트로닉스공학과) ;
  • 정명영 (부산대학교 광메카트로닉스공학과)
  • Received : 2016.03.16
  • Accepted : 2016.03.29
  • Published : 2016.03.30
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Abstract

In this study, development of multichannel filter module and characteristic evaluation for bio imaging were studied. The filter module was fabricated in order to realize near infrared fluorescence imaging of 700 nm and 800 nm wavelength ranges, and contrast imaging analysis for characteristic evaluation of the filter module was studied through signal to back ground ratio (SBR), controlled by parameters such as magnification, exposure, gain. Furthermore, phantoms, which are biomimetic tissue with equal optical properties of kidney and liver, were fabricated to study characteristics of both filter module depending on thickness and exposure amount of light source for bio imaging analysis. The fabricated filter module has more than 4 of SBR difference despite changes of magnification, exposure, gain, and in the case of the kidney phantom and the liver phantom, contrast imaging of more than 4 of SBR was confirmed on 50 mA, 60 mA exposure amount of light source respectively.

본 연구에서는 생체 영상 이미징을 위한 다채널 필터 모듈 개발 및 특성 평가 연구를 수행하였다. 필터 모듈은 700 nm 및 800 nm 파장대의 근적외선 형광 이미징을 동시에 구현할 수 있도록 제작되었으며, 모듈의 특성 평가를 위해 magnification, exposure, gain의 변수에 따른 signal to back ground ratio (SBR)을 통한 대조영상 평가를 진행하였다. 또한 생체 영상 분석을 위해 신장 및 간의 광학적 특성이 동일한 생체 모사 조직인 phantom을 제작하여 두께에 따른 필터 모듈의 특성 및 광원의 주입량에 따른 특성 연구를 진행하였다. 제작된 필터 모듈은 magnification, exposure, gain의 변화에도 4이상의 SBR 차이를 보이며, kidney phantom 및 liver phantom의 경우 각각 50 mA, 60 mA의 광원 주입량에서 4이상의 SBR 대조 영상을 확인하였다.

Keywords

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