Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Antioxidative Activities of Sanguisorba officinalis L. in Diabetic Rats

당뇨를 유도한 동물모델에서 지유 추출물의 항산화 활성

  • Jo, Jin Ha (Department of Bio Environmental Chemistry, College of Agriculture and Life Science, Chungnam National University) ;
  • Bae, Eun Young (LINC project group, Daejeon University) ;
  • Lee, Tae Kyoung (Department of Physiology, College of Korean Medicine, Daejeon University) ;
  • Kim, Myung Hyun (Department of Physiology, College of Korean Medicine, Daejeon University) ;
  • Lee, Seung Woong (Natural Product Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Byoung Soo (Department of Physiology, College of Korean Medicine, Daejeon University) ;
  • Lim, Chi Hwan (Department of Bio Environmental Chemistry, College of Agriculture and Life Science, Chungnam National University)
  • 조진하 (충남대학교 농업생명과학대학 생물환경화학과) ;
  • 배은영 (대전대학교 LINC 사업단) ;
  • 이태경 (대전대학교 한의과대학 생리학교실) ;
  • 김명현 (대전대학교 한의과대학 생리학교실) ;
  • 이승웅 (한국생명공학연구원 천연물소재연구센터) ;
  • 김병수 (대전대학교 한의과대학 생리학교실) ;
  • 임치환 (충남대학교 농업생명과학대학 생물환경화학과)
  • Received : 2016.01.18
  • Accepted : 2016.04.06
  • Published : 2016.04.30
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Abstract

Background: Sanguisorba officinalis has been used in traditional Asian medicine owing to its beneficial effects on various diseases. The purpose of this study was to evaluate the effect of S. officinalis on the antioxidant system of Streptozotocin (STZ) and Alloxan (ALL) induced diabetic rats. Methods and Results: Triglyceride and Low-Density Lipoprotein (LDL)-cholesterol levels decreased in the STZ-induced diabetic groups treated with S. officinalis extract (SOE) compared to the corresponding levels in the control groups. Moreover, in the ALL-induced diabetic groups, SOE reduced triglyceride, LDL-cholesterol, and High-Density Lipoprotein (HDL)-cholesterol levels. Malondialdehyde (MDA) levels decreased significantly in the STZ and ALL-induced groups treated with SOE compared to the corresponding levels in the control group. Further, Glutathione (GSH) levels increased but did not reach statistical significance. The levels of Superoxide Dismutase (SOD) and Glutathione-S-Transferase (GST) showed a tendency to recover with SOE treatment in the STZ and ALL-induced diabetic groups. In addition, Catalase (CAT) levels in the SOE treatment group decreased significantly compared to those in the control group. Conclusions: These results suggest that SOE might be an effective agent in attenuating oxidative stress in diabetic patients by improving blood lipid profiles and inducing the anti-oxidative enzyme systems.

Keywords

References

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