Journal of Korean Medicine Rehabilitation (한방재활의학과학회지)

The society of Korean Medicine Rehabilitation (한방재활의학과학회)
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Influence of Galgeun-tang on Gene Expression in Diet-Induced Obese Mice

갈근탕이 고지방 식이 유발 비만 쥐에서 비만 관련 유전자 발현에 미치는 영향

  • Ye, Sung-Ae (Department of Korean Rehabilitation Medicine, College of Korean Medicine, Gachon University) ;
  • Kim, Ho-Jun (Department of Korean Rehabilitation Medicine, College of Korean Medicine, Dongguk University) ;
  • Ko, Seong-Gyu (Department of Preventive Medicine, College of Korean Medicine, Kyunghee University) ;
  • Song, Yun-Kyung (Department of Korean Rehabilitation Medicine, College of Korean Medicine, Gachon University)
  • 예성애 (가천대학교 한의과대학 한방재활의학과교실) ;
  • 김호준 (동국대학교 한의과대학 한방재활의학교실) ;
  • 고성규 (경희대학교 한의과대학 예방의학교실) ;
  • 송윤경 (가천대학교 한의과대학 한방재활의학과교실)
  • Received : 2016.03.28
  • Accepted : 2016.04.12
  • Published : 2016.04.30
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Abstract

Objectives The purpose of this study was to evaluate anti-obesity effect of Galgeuntang (gegentang) and elucidate the effect of it on gene expression related to obesity. Methods The experiments were performed with the use of Diet-Induced Obese mice. They were grouped NC (normal control), HFD (high fat diet control), GGT (Galgeun-tang (gegentang), 700 mg/kg), ORL (Orlistat, 10 mg/kg). GGT was orally administered for 12 weeks. Body weight was measured every week. Real-time PCR was performed to investigate the effect of GGT on gene expression in liver tissue. Results GGT group and ORL group were reduced in body weight compared with HFD. HFD increased $PPAR{\gamma}$, SREBP-1, Leptin, aP2, FATP1, FAS gene expression compared with NC. GGT increased FATP1 gene expression. But GGT reduced $PPAR{\gamma}$ & FAS gene expression in liver tissue of diet-induced obese mice compared with HFD. Conclusions These results suggest that GGT is supposed to have a certain impact on the treatment of obesity. But more study is needed in the future.

Keywords

References

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