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뇌졸중환자의 변비에서 지실 열수 추출물의 효과

Effect of an Aqueous Extract of Poncirus trifoliate (L.) Raf. in Stroke Patient with Constipation

  • 문효정 (원광대학교 의과대학 재활의학과, 원광의과학연구소) ;
  • 이수경 (원광대학교 한의대학 한방재활의학과) ;
  • 노세응 (원광대학교 의과대학 재활의학과, 원광의과학연구소) ;
  • 주민철 (원광대학교 의과대학 재활의학과, 원광의과학연구소)
  • Moon, Hyo Jeong (Department of Rehabilitation Medicine and Institute of Wonkwang Medical Science, Wonkwang University School of Medicine) ;
  • Lee, Su Kyung (Department of Rehabilitation Medicine of Korean Medicine, Wonkwang University School of Korean Medicine) ;
  • Noh, Se Eung (Department of Rehabilitation Medicine and Institute of Wonkwang Medical Science, Wonkwang University School of Medicine) ;
  • Joo, Min Cheol (Department of Rehabilitation Medicine and Institute of Wonkwang Medical Science, Wonkwang University School of Medicine)
  • 투고 : 2016.03.24
  • 심사 : 2016.04.12
  • 발행 : 2016.04.30

초록

Objectives To evaluate the effects and safety of the aqueous extract of the dried, immature fruit of Poncirus trifoliate (L.) Raf. (Rutaceae) (PF) in stroke patients with constipation. Methods A total of 22 patients were recruited. Patients were interviewed about the clinical informations, constipation score and Bristol stool form scale at twice, before intake PF and after intake PF 2 weeks. The total and segmental colon transit time (CTT) were measured by using radio-opaque markers (Kolomark$^{(R)}$). The degree of stool retention was evaluated by the plain abdominal radiography and was scored by Leech score. Results Before intake PF, constipation scores ranged from 3 to 12, average $6.54{\pm}2.87$ and Bristol stool form scale ranged from 1 to 6, average $3.86{\pm}1.21$. CTTs were $9.05{\pm}6.89hours$, $14.29{\pm}10.68hours$, $12.11{\pm}7.19hours$ and $35.40{\pm}19.5hours$ in the right, left, rectosigmoid and total colon, respectively. Stool retention score was $2.45{\pm}0.61$, $2.3{\pm}0.86$, $1.9{\pm}0.85$, $6.65{\pm}1.56$ in the right, left, rectosigmoid and total colon, respectively. After 2 weeks, constipation scores ranged from 2 to 8, average $4.28{\pm}2.05$ and Bristol stool form scale ranged from 1 to 6, average $4.17{\pm}1.04$. CTTs were $7.41{\pm}8.86hours$, $11.12{\pm}9.12 hours$, $8.83{\pm}8.75hours$ and $27.3{\pm}20.2$ hours in the right, left, rectosigmoid and total colon, respectively. Stool retention score was $1.9{\pm}0.64$, $2.2{\pm}0.69$, $1.4{\pm}0.88$, $5.5{\pm}1.39$ in the right, left, rectosigmoid and total colon, respectively. There were statistically significant difference in the total and rectosigmoid colon CTT and constipation score, Stool retention score in right and rectosigmoid colon (p<0.05) after PF therapy. Conclusions These results suggest potential for PF therapy in stroke patient with constipation.

키워드

참고문헌

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