Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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A Detrimental Role of Immunosuppressive Drug, Dexamethasone, During Clostridium difficile Infection in Association with a Gastrointestinal Microbial Shift

  • Kim, Hyeun Bum (Department of Infectious Disease and Global Health, Tufts University) ;
  • Wang, Yuankai (Department of Infectious Disease and Global Health, Tufts University) ;
  • Sun, Xingmin (Department of Molecular Medicine, Morsani College of Medicine, University of South Florida)
  • Received : 2015.12.08
  • Accepted : 2016.01.17
  • Published : 2016.03.28
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Abstract

We investigated the increased risk of Clostridium difficile infection (CDI) caused by the combined use of antibiotics and an immunosuppressive drug in a mouse model. Our data showed that an approximate return to pretreatment conditions of gut microbiota occurred within days after cessation of the antibiotic treatment, whereas the recovery of gut microbiota was delayed with the combined treatment of antibiotics and dexamethasone, leading to an increased severity of CDI. An alteration of gut microbiota is a key player in CDI. Therefore, our data implied that immunosuppressive drugs can increase the risk of CDI through the delayed recovery of altered gut microbiota.

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