Journal of Dairy Science and Biotechnology

Korean Society of Dairy Science and Biotechnology (한국낙농식품응용생물학회)
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Growth Factors and Their Function in Colostrum: A Review

초유에 함유된 성장인자와 기능: 총설

  • Renchinkhand, Gereltuya (Lab. of Milk Food Biochemistry and Biotechnology, College of Agriculture and Life Sciences, Chungnam National University) ;
  • Son, Ji Yoon (Lab. of Milk Food Biochemistry and Biotechnology, College of Agriculture and Life Sciences, Chungnam National University) ;
  • Nam, Myoung Soo (Lab. of Milk Food Biochemistry and Biotechnology, College of Agriculture and Life Sciences, Chungnam National University)
  • 렌친핸드 (충남대학교 농업생명과학대학 동물바이오시스템과학) ;
  • 손지윤 (충남대학교 농업생명과학대학 동물바이오시스템과학) ;
  • 남명수 (충남대학교 농업생명과학대학 동물바이오시스템과학)
  • Received : 2016.01.20
  • Accepted : 2016.02.28
  • Published : 2016.03.31
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Abstract

Colostrum, a nutrient-rich fluid produced by female mammals after giving birth, is the specific initial diet of mammalian neonates. Colostrum is important for the nutrition, growth, and development of newborn infants and contributes to the immunologic defense of neonates. It contains immunoglobulins, antimicrobial peptides, such as lactoferrin and lactoperoxidase, and other bioactive molecules, including growth factors, such as IGF (insulin-like growth factor), EGF (epithermal growth factor), $TGF-{\beta}$ (transforming growth factor), and FGF (fibroblast growth factor). Bovine colostrum is a rich source of growth factors, which play a central role in wound healing. The biological activities of colostrum emphasize the relevance of the synergistic activity of growth factors to stimulate keratinocyte proliferation and migration, which are essential for tissue repair. Colostrum increases the expression of early differentiation markers, such as keratin 1 and 10 and involucrin, and late differentiation markers, including loricrin and filaggrin. Additionally, colostrum increases granulation tissue volume in the dermis, suggesting that it has a beneficial effect on wound healing. The therapeutic use of colostrum or individual peptides present in colostrum has a positive and curative influence on various gastrointestinal diseases.

젖소 초유에는 성장인자가 풍부하게 함유되어 있는데, 상처 치유에 중요한 역할을 하고, 초유의 생리활성 기능을 담당하고 있다. Tyrosine kinase receptor의 활성을 유도하는 성장인자가 특이적으로 관여하여 세포의 분화, 면역기능, 신경기능 등 세포간 상호작용에 관여하는 EGFR(상피증식인자 수용체)와 FGFR(섬유아세포 증식인자)가 있다. 또한 VEGFR (혈관내피 증식인자)와 PDGF(혈소판유래 증식인자)도 존재한다. 조직회복을 위한 각질세포 분화와 세포의 이행에 성장인자가 상승효과를 나타내었고, 초유 또는 초유에 포함된 성장인자 peptide들은 장관질환 치료에 효과가 있으므로 치료제로 이용 가능성을 보여주었다.

Keywords

References

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