Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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Appearance of osteoporosis in rat experimental autoimmune encephalomyelitis

  • Ahn, Meejung (School of Medicine, College of Veterinary Medicine, Jeju National University) ;
  • Kang, Sohi (Department of Veterinary Anatomy, College of Veterinary Medicine, Chonnam National University) ;
  • Park, Channam (Department of Veterinary Anatomy, College of Veterinary Medicine, Jeju National University) ;
  • Kim, Jeongtae (Department of Molecular Anatomy, School of Medicine, University of the Ryukyus) ;
  • Jung, Kyungsook (Korea Research Institute of Bioscience and Biotechnology, Korea Research Institute of Bioscience and Biotechnology) ;
  • Yang, Miyoung (Department of Anatomy, School of Medicine, Wonkwang University) ;
  • Kim, Sung-Ho (Department of Veterinary Anatomy, College of Veterinary Medicine, Chonnam National University) ;
  • Moon, Changjong (Department of Veterinary Anatomy, College of Veterinary Medicine, Chonnam National University) ;
  • Shin, Taekyun (Department of Veterinary Anatomy, College of Veterinary Medicine, Jeju National University)
  • Received : 2016.03.24
  • Accepted : 2016.05.26
  • Published : 2016.06.30
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Abstract

Experimental autoimmune encephalomyelitis (EAE) in Lewis rats is characterized by transient paralysis followed by recovery. To evaluate whether transient paralysis in EAE affects bone density, tibiae of EAE rats were morphologically investigated using micro-computed tomography and histology. The parameters of bone health were significantly reduced at the peak stage of EAE rats relative to those of controls (p < 0.05). The reduction of bone density was found to remain unchanged, even in the recovery stage. Collectively, the present data suggest that osteoporosis occurs in paralytic rats with monophasic EAE, possibly through the disuse of hindlimbs and/or autoimmune inflammation.

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References

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