Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
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The Changes of NO, nNOS, Norepinephrine by Acupucture at LU7, HT5, PC6 Acupoints in Rats

수삼음경의 락혈 침자가 백서의 혈위 조직내 nNOS. NO와 조직 및 혈장 Norepinephrine의 변화에 미치는 영향

  • Shin, Wook (College of Korean Medicine, Dongshin University) ;
  • Lee, Yumi (College of Korean Medicine, Dongshin University) ;
  • Lee, Kyoungin (Biotechnology Industrialization Center, Dongshin University) ;
  • Choi, Donghee (College of Korean Medicine, Dongshin University) ;
  • Kim, Mirae (College of Korean Medicine, Dongshin University) ;
  • Na, Changsu (College of Korean Medicine, Dongshin University) ;
  • Kim, Sunmin (Biotechnology Industrialization Center, Dongshin University) ;
  • Pyo, Byoungsik (Biotechnology Industrialization Center, Dongshin University) ;
  • Youn, Daehwan (College of Korean Medicine, Dongshin University)
  • 신욱 (동신대학교 한의과대학) ;
  • 이유미 (동신대학교 한의과대학) ;
  • 이경인 (동신대학교 생물자원산업화지원센터) ;
  • 최동희 (동신대학교 한의과대학) ;
  • 김미래 (동신대학교 한의과대학) ;
  • 나창수 (동신대학교 한의과대학) ;
  • 김선민 (동신대학교 생물자원산업화지원센터) ;
  • 표병식 (동신대학교 생물자원산업화지원센터) ;
  • 윤대환 (동신대학교 한의과대학)
  • Received : 2016.06.07
  • Accepted : 2016.06.18
  • Published : 2016.06.27
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Abstract

Objectives : A previous study demonstrated that the connecting points of three yang meridians attenuated changes of nNOS, and Norepinephrine(NE) in rats. The current study investigated the changes in nNOS, NO and NE upon the needle insertion at varying depths at the connecting point of three yin meridians of the hand. Methods : Needles were inserted into rats, on both left and right sides of the connecting point, including the LU7, HT5 and PC6 acupoints which are three yin meridians of the hand. After insertion, needles were retained for five minutes. Each acupuncture groups were treated acupuncture at each acupoint and at the depths of superficial, middle and deep layer. After the retention, blood was drawn via cardiac puncture, and tissues of each point near meridian vessel was extracted to examine the changes in the expression of nNOS, NO and NE. Results : Compared with the superficial layer group, nNOS production significantly decreased in the middle and deep layer at LU7 acupoint group and in the deep layer at HT5, PC6 acupoint group. The tissue NE decreased in the deep layer on PC6 acupoint and the plasma NE increased at the middle layer at LU7 acupoint group but decreased at the deep layer on at LU7 acupoint group. Conclusions : Acupuncture at connecting points of three yin meridians of the hand can regulate the activities of nNOS, and NE.

Keywords

References

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