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Effects of Non-Alcoholic Fatty Liver in Rats by Acer tagmentosum Maxim. Extract

산겨릅나무 추출물을 이용한 비알콜성 지방간 개선 효과

  • Seo, Yoonhee (Dept. of Biology, Chungbuk National University) ;
  • Lee, Sang-Hwa (Bio Organic Material & Food Center, Seowon University) ;
  • Hwang, Hyung Seo (Dept. of Integrated Oriental Medical Bioscience, Semyung University) ;
  • Choe, Soo Young (Dept. of Biology, Chungbuk National University)
  • 서윤희 (충북대학교 생물학과) ;
  • 이상화 (서원대학교 친환경바이오소재 및 식품센터) ;
  • 황형서 (세명대학교 한방바이오융합과학부) ;
  • 최수영 (충북대학교 생물학과)
  • Received : 2016.04.18
  • Accepted : 2016.05.30
  • Published : 2016.06.30

Abstract

This study was performed to investigate the effects of Acer tegmentosum Maxim. extract (ATE) on non-alcoholic fatty liver in Sprague Dawley (SD) rats. During oral administration of ATE, non-alcoholic fatty liver was induced by treatment with DL-ethionine. The lipid, total cholesterol (T-CHO) and malondialdehyde (MDA) in the liver tissue of ATE-fed rats showed lower levels, as compared to ATE-unfed rats. In ATE-fed rats, the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and ${\gamma}$-glutamyl transferase (GGT) were lower than the case of ATE-unfed rats. Oil red staining of the liver showed that the lipid deposits were decreased by feeding ATE. These results strongly indicated that ATE has positive effects of protection against non-alcoholic fatty liver formation.

Acknowledgement

Supported by : 서원대학교

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