Pharmacological Treatments of Headache

두통의 약물학적 치료

  • Na, Eun-Jin (Department of Psychiatry, Chonbuk National University Medical School) ;
  • Park, Jong-Il (Department of Psychiatry, Chonbuk National University Medical School) ;
  • Yang, Jong-Chul (Department of Psychiatry, Chonbuk National University Medical School)
  • 나은진 (전북대학교 의학전문대학원 정신과학교실) ;
  • 박종일 (전북대학교 의학전문대학원 정신과학교실) ;
  • 양종철 (전북대학교 의학전문대학원 정신과학교실)
  • Received : 2016.05.27
  • Accepted : 2016.06.20
  • Published : 2016.06.30

Abstract

Headache is one of the most common physical symptoms which almost everyone experience at least once during a life. Headache is often associated with disability, but rarely with secondary headache which could result in a serious life-threatening illness, i.e. brain tumor. However, in most cases, headache is a benign illness which comprises a primary headache, i.e. migraine or tension-type headache. The accurate diagnosis of headache is critical for clinicians and it begins with history taking and physical examination since there are no diagnostic tests for primary headaches. Nowadays, there are a wide variety of pharmacological treatments according to each headache disorder. The specific purposes of this review are introducing history of classification of headache disorder and presenting diagnostic process of headache disorder. Then, we discuss the effective pharmacological treatment strategies of each headache disorder.

두통은 대부분의 사람들이 평생 한번씩은 경험하는 가장 흔한 신체증상이다. 심각한 상황을 야기하는 뇌종양과 같은 일부의 원인을 제외하고, 두통의 대부분은 편두통이나 긴장성 두통과 같은 일차성 두통으로 알려져 있다. 두통의 정확한 진단은 임상의들의 자세한 병력 청취와 신체 검사로부터 시작된다. 본 종설에서는 두통의 세부진단과 진단과정에 대해 고찰하고, 효과적인 약물치료 전략에 대해서 논의하고자 한다.

Keywords

References

  1. Jensen R, Stovner LJ. Epidemiology and comorbidity of headache, Lancet Neurol 2008;7:354-361. https://doi.org/10.1016/S1474-4422(08)70062-0
  2. Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias, and facial pain. Cephalalgia 1988;8:1-96. https://doi.org/10.1046/j.1468-2982.1988.0801001.x
  3. Headache Classification Committee of the International Headache Society. The international classification of headache disorders(second edition). Cephalalgia 2004;24:1-160.
  4. Headache Classification Committee of the International Headache Society. The international classification of headache disorders 3rd edition beta. Cephalalgia 2013;33:627-808. https://doi.org/10.1177/0333102413487610
  5. 대한두통학회. 두통학: 군자출판사;2009. p.16-37.
  6. 이강건. 두통의 감별과 치료. Korean J Fam Pract 2013;3:255-259.
  7. Silberstein SD, Lipton RB, Dalessio DJ. Wolff's headache and other head pain. Oxford university press;2001. p.6-26.
  8. Randall CC. Evaluation of Acute Headaches in Adults. Am Fam Physician 2001;63:685-693.
  9. Newman LC, Lipton RB. Emergency department evaluation of headache. Neurol Clin 1998;16:285-303. https://doi.org/10.1016/S0733-8619(05)70065-7
  10. Werner JB. The premonitory phase of migraine and migraine management. Cephalalgia 2012;33:1117-1121.
  11. Cutrer FM, Huerter K. Migraine aura. The Neurologist 2007;13:118-125. https://doi.org/10.1097/01.nrl.0000252943.82792.38
  12. 대한두통학회. 두통학: 군자출판사;2009. p.121-142.
  13. Lipton RB, Stewart WF, Stone AM, Lainez MJA, Sawyer JP. Stratified care vs step care strategies for migraine: the Disability in Strategies of Care(DISC) Study: A randomized trial. JAMA 2000;284:2599-2605. https://doi.org/10.1001/jama.284.20.2599
  14. Silberstein SD, Goadsby PJ, Lipton RB. Management of migraine: an algorithmic approach. Neurology 2000;55:46-52. https://doi.org/10.1212/WNL.55.1.46
  15. 이광수. The Diagnosis and Most-Updated Therapy of Migraine. J Korean Med Assoc 2009;52:500-506. https://doi.org/10.5124/jkma.2009.52.5.500
  16. 주민경. 편두통의 진단과 치료. J Korean Acad Fam Med 2006;27:425-435.
  17. 정진상. Drug Therapy for Migraine. J Korean Med Assoc 2007;50:917-923. https://doi.org/10.5124/jkma.2007.50.10.917
  18. Rapoport AM. Acute and prophylactic treatments for migraine: present and future. Neurol Sci 2008;29:110-122.
  19. Fumal A, Schoenen J. Tension-type headache: Current research and clinical management. Lancet Neurol 2008;7:70-83. https://doi.org/10.1016/S1474-4422(07)70325-3
  20. Lenaerts ME. Pharmacoprophylaxis of tension-type headache. Curr Pain Headache Rep 2005;9:442-447. https://doi.org/10.1007/s11916-005-0025-4
  21. Goadsby PJ, Cittadini E, Burns B, Cohen AS. Trigeminal autonomic cephalalgias: diagnostic and therapeutic developments. Current Opin Neurol 2008;21:323-330. https://doi.org/10.1097/WCO.0b013e3282fa6d76
  22. May A, Jurgens TP. Trigeminal autonomic headaches in daily clinical practice. Expert Rev Neurothe 2006;6:1525-1532.