Nonlinear wave loads can lead to resonant responses of offshore structures in sum or difference frequencies. In this study, the roll motion of an FPSO with a low natural frequency is simulated in the time domain. To generate the time signals of wave loads, the quadratic transfer functions of the second-order excitations are calculated in the frequency domain. The equations of motions based on the time memory functions are used to evaluate the roll responses in irregular waves. The roll damping in empirical form is accounted for in the simulation.