Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effects of Herbal Mixture Extracts Containing Angelica gigas Nakai and Cuscuta chinensis Lam. on Menopausal Symptoms in Ovariectomized Rats

당귀(Angelica gigas N.)와 토사자(Cuscuta chinensis Lam.)를 포함하는 생약 복합 추출물의 폐경 동물모델에서의 갱년기 증상 완화 효과

  • Kim, Suji (Department of Food Science and Biotechnology, Sungkyunkwan University) ;
  • Jang, Byung-Hyun (Department of Food Science and Biotechnology, Sungkyunkwan University) ;
  • Chang, Seo-Hyuk (Department of Food Science and Biotechnology, Sungkyunkwan University) ;
  • Kang, Hee (Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Park, Ki-Moon (Department of Food Science and Biotechnology, Sungkyunkwan University) ;
  • Ahn, Duk Kyun (Korea Herb Clinical Research Center) ;
  • Kim, Soohyun (Beauty Food Research Team, Amorepacific Inc.) ;
  • Kim, Sunmi (Beauty Food Research Team, Amorepacific Inc.) ;
  • Seo, Daebang (Beauty Food Research Team, Amorepacific Inc.) ;
  • Shin, Song Seok (Beauty Food Research Team, Amorepacific Inc.) ;
  • Park, Kye Won (Department of Food Science and Biotechnology, Sungkyunkwan University)
  • 김수지 (성균관대학교 식품생명공학과) ;
  • 장병현 (성균관대학교 식품생명공학과) ;
  • 장서혁 (성균관대학교 식품생명공학과) ;
  • 강희 (경희대학교 동서의학대학원) ;
  • 박기문 (성균관대학교 식품생명공학과) ;
  • 안덕균 (한국본초임상연구소) ;
  • 김수현 ((주)아모레퍼시픽 뷰티푸드연구팀) ;
  • 김선미 ((주)아모레퍼시픽 뷰티푸드연구팀) ;
  • 서대방 ((주)아모레퍼시픽 뷰티푸드연구팀) ;
  • 신송석 ((주)아모레퍼시픽 뷰티푸드연구팀) ;
  • 박계원 (성균관대학교 식품생명공학과)
  • Received : 2016.05.02
  • Accepted : 2016.06.03
  • Published : 2016.08.31
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Abstract

During menopause, elderly woman experience physical and emotional symptoms, including hot flashes, night sweats, weight gain, vaginal dryness, and mood swings. In this study, we investigated the effects of mixed herbal extracts containing Angelica gigas Nakai and Cuscuta chinensis Lam. on menopause symptoms in ovariectomized (OVX) rats. Daily oral treatments of 500 mg/kg and 1,000 mg/kg in OVX rats for 8 weeks significantly reduced weight gain, inhibited hepatic lipid accumulation, and lowered serum lipid levels comparable to the effects induced by estradiol treatments. Mixed herbal extracts (named Jaeummidan) also prevented vaginal dryness as measured by increased vaginal weight. Increased vaginal weight was associated with enlarged epithelium thickness. These data show the preventive actions of Jaeummidan against menopause symptoms and further suggest the possibility of developing functional ingredients in elderly human populations experiencing menopause symptoms.

대부분의 여성은 폐경 이후 신체적 변화를 겪게 된다. 폐경의 증상으로는 홍조, 발한, 몸무게의 증가와 질 건조증 등이 있다. 본 연구에서는 여성의 폐경기 증상 완화에 효능이 있는 열 가지 종류의 생약을 조합하여 만든 혼합 추출물이 동물의 폐경 모델인 난소절제(ovariectomized, OVX) 레트에 어떠한 영향을 미치는지 알아보고자 하였다. 경구투여를 통해 각각 500 mg/kg/d, 1,000 mg/kg/d 농도의 열수 추출물(자음미단)을 8주간 섭취시켰으며, 양성대조군으로 에스트라디올($50{\mu}g/mL$)을 사용하였다. 실험을 통해 자음미단이 난소절제 레트에서 몸무게를 유의적으로 감소시켰으며, 간에서의 지방 함량 증가를 억제함을 확인하였다. 자음미단의 섭취는 페경 후 증가하는 혈액의 중성지방과 콜레스테롤 수치도 감소시켰다. 또한, 자음미단은 질의 무게를 증가시켰으며, 특히 질 내벽의 상피세포의 두께에 영향을 주었다. 자음미단의 1,000 mg/kg/d의 농도에서는 에스트로디올과 유사한 정도의 내벽 두께를 관찰할 수 있었다. 따라서 본 실험을 통해 자음미단이 폐경기 여성의 증상인 비만, 대사질환 및 질 건조증의 증상을 완화해줄 수 있으며, 이를 활용한 기능성 식품의 개발이 기대된다.

Keywords

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