Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Anti-Obesity Effect of Eriobotrya japonica Leaves Extract on Obese Mice Induced by High-Fat Diet

비파잎 추출물이 고지방식이로 유도한 비만쥐에 미치는 항비만 효과

  • Lee, Somi (Fruit Research Institute (Jeollanamdo Agricultural Research & Extension Service)) ;
  • Park, Moonyoung (Fruit Research Institute (Jeollanamdo Agricultural Research & Extension Service)) ;
  • Kim, Ok Kyung (Department of Medical Nutrition and Research Institute of Medical Nutrition, Kyung Hee University) ;
  • Lee, Jeongmin (Department of Medical Nutrition and Research Institute of Medical Nutrition, Kyung Hee University) ;
  • Jun, Woojin (Department Food and Nutrition, Chonnam National University)
  • 이소미 (전남농업기술원 과수연구소) ;
  • 박문영 (전남농업기술원 과수연구소) ;
  • 김옥경 (경희대학교 동서의학대학원 의학영양학과) ;
  • 이정민 (경희대학교 동서의학대학원 의학영양학과) ;
  • 전우진 (전남대학교 생활과학대학 식품영양과학부)
  • Received : 2016.04.11
  • Accepted : 2016.07.05
  • Published : 2016.08.31
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Abstract

This study investigated the anti-obesity effects of Eriobotrya japonica leaves extract (EJE) in a high-fat diet-induced obese mice model. For the analysis, 40 mice were randomly divided into five groups: normal diet (ND), high-fat diet group (HD), high-fat diet containing EJE 100 mg/kg b.w. (EJE-L), 500 mg/kg b.w. (EJE-H), and Garcinia cambogia extract 100 mg/kg b.w. in each AIN 93G supplement for 8 weeks as positive control. During the study period, food intake and body weight were measured separately. Body weight, serum triglyceride level, and total cholesterol levels of the EJE group were significantly lower than those of the HD and ND. Moreover, mice fed an EJE-containing high-fat diet showed decreased leptin levels compared with high-fat diet-induced obese mice. These results suggest that EJE has potential as an anti-obesity agent by reducing body weight and improving levels of triglycerides, total cholesterol, low density lipoprotein-cholesterol, and leptin in serum.

본 연구는 비파잎 추출물이 고지방식이로 유도한 비만쥐에 미치는 항비만 효과를 조사하였다. 8주 동안 고지방식이에 100 mg/kg b.w., 500 mg/kg b.w.의 비파잎 추출물을 보충한 그룹과 고지방식이군만을 제공한 그룹을 비교하였다. 비파잎 추출물은 식이섭취량에는 영향을 주지 않으면서도 고지방식이군과 비교하여 유의적으로 체중증가를 줄이고 내장지방의 축적을 억제하였다. 또한, 비파잎 추출물을 급여한 군은 고지방식이군과 비교하여 혈중 지질, 간지질의 축적, 혈중 렙틴 농도를 감소시켰다. 이상의 실험 결과로 고지방식 이와 함께 급여한 비파잎 추출물은 체중, 간 및 지방조직의 무게 감소와 더불어 혈장 지질 농도를 개선하고 혈장 렙틴농도를 감소시키므로 항비만 효과를 가진 천연 기능성 식품의 소재로써 활용 가능성이 있을 것으로 생각된다.

Keywords

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