한국콘텐츠학회논문지 (The Journal of the Korea Contents Association)

  • 제16권8호
  • /
  • Pages.477-483
  • /
  • 2016
  • /
  • 1598-4877(pISSN)
  • /
  • 2508-6723(eISSN)
한국콘텐츠학회 (The Korea Contents Association)
권호 표지
DOI QR코드

DOI QR Code

금 나노입자를 활용한 두부 모의피폭체에서의 선량증가 효과 평가

Evaluation of Dose Enhancement by Gold Nanoparticles using Mathematical Head Phantom

  • 황철환 (부산대학교병원 방사선종양학과) ;
  • 박은태 (인제대학교 부산백병원 방사선종양학과) ;
  • 김정훈 (부산가톨릭대학교 보건과학대학 방사선학과)
  • 투고 : 2016.03.30
  • 심사 : 2016.05.09
  • 발행 : 2016.08.28
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

두부 모의피폭체를 활용하여 MV X, ${\gamma}$선에서의 선량증가 효과와 금 나노입자의 크기, 물질의 농도에 대한 의존성을 평가하였다. MCNPX code를 이용하여 Monte Carlo 시뮬레이션 기법을 적용하였으며, 입사 에너지는 4, 6, 10, 15 MV X선, Co60 ${\gamma}$선을 사용하였다. 두부 모의피폭체 내에 종양을 묘사하고 내부에 25, 75, 125 nm 직경의 금 나노입자를 삽입하였다. 나노입자의 농도는 5, 15, 25 mg/g을 적용하였으며, 선량 증가 물질이 없을 때를 기준으로 하여 선량증가비를 산출하였다. 입사 에너지가 낮을수록, 선량증가 물질의 농도가 높을수록 높은 선량증가비를 나타내었다. 나노입자의 크기는 입사 에너지가 낮고, 물질의 농도가 높을수록 상대적으로 높은 의존성을 보였다. 금 나노입자를 이용한 선량증가 효과를 나타내는데 기초자료로 활용할 수 있을 것으로 사료된다.

The effect of dose enhancement was evaluated using Snyder head phantom, dependence on size of gold nanoparticle and material concentration in megavoltage X, ${\gamma}$-ray. Monte Carlo simulation using MCNPX was used for 4, 6, 10, 15 MV and Co-60 ${\gamma}$-ray. Described the tumor in Snyder head phantom, gold nanoparticle of 25, 75, 125nm diameter was inserted inside tumor. Concentration of dose enhancement material was used for 5, 15, 25 mg/g and dose enhancement factor was calculated on the basis of the no dose enhancement material. The lower incident energy and the higher concentration of material were that high dose enhancement factor is indicated. The size of gold nanoparticle had relatively high dependence on lower incident energy and higher concentration of material. It will increase dose inside the tumor, and be additional effect of use of gold nanoparticles in radiation therapy.

키워드

참고문헌

  1. T. John and Lyman, "Complication probability as assessment from dose-volume histograms," Radiation Research, Vol.104, pp.13-19, 1985. https://doi.org/10.2307/3576626
  2. 김영재, 장영일, 지연상, 한재복, 최남길, 장성주, "4차원 방사선 치료시 Body fix의 유용성 평가," 한국콘텐츠학회논문지, Vol.13, No.5, pp.420-426, 2013. https://doi.org/10.5392/JKCA.2013.13.05.420
  3. J. E. Sardi, M. A. Boixadera, and J. J. Sardi, "A critical overview of concurrent chemoradiotherapy in cervical cancer," Curr Oncol Rep, Vol.6, pp.463-70, 2004. https://doi.org/10.1007/s11912-004-0077-3
  4. H. P. Kok, J. Crezee, and N. A. Franken, "Quantifying the combined effect of radiation therapy and hyperthermia in terms of equivalent dose distributions," Int J Radiat Oncol Biol Phys, Vol.88, pp.739-45, 2014. https://doi.org/10.1016/j.ijrobp.2013.11.212
  5. L. Sim, A. Fielding, and M. English, "Enhancement of biological effectiveness of radiotherapy treatments of protstate cancer cells in vitro using gold nanoparticle," Coogee Beach, Sydney, International Nanomedicine Conference, 2011.
  6. S. H. Cho, "Estimation of tumor dose enhancement due to GNPs during typical radiation treatments: a preliminary Monte Carlo study," Phys Med Biol, Vol.50, pp.163-173, 2010.
  7. M. Y. Chang, A. L. Shiau, and Y. H. Chen, "Increased apoptotic potential and dose-enhancing effect of gold nanoparticles in combination with single-dose clinical electron beams on tumor-bearing mice," Cancer Sci, Vol.99, pp.1479-1484, 2008. https://doi.org/10.1111/j.1349-7006.2008.00827.x
  8. D. B. Chithrani, S. Jelveh, and F. Jalali, "Gold nanoparticles as radiation sensitizers in cancer therapy," Radiat Res, Vol.173, pp.719-728, 2010. https://doi.org/10.1667/RR1984.1
  9. J. F. Hainfeld, F. A. Dilmanian, and D. N. Slatkin, "Radiotherapy enhancement with gold nanoparticles," J Pharm Pharmacol, Vol.60, pp.977-85, 2008. https://doi.org/10.1211/jpp.60.8.0005
  10. P. Reti, S. Pinel, and M. Toussaint, "Nanoparticle for radiation therapy enhancement: the key parameters," Theranostics, Vol.5, pp.1030-1045, 2015. https://doi.org/10.7150/thno.11642
  11. W. Ngwa, H. Korideck, and A. Kassis, "In vitro radiosensitization by gold nanoparticles during continuous low-dose-rate gamma irradiation with I-125 brachytherapy seeds," Nanomedicine, Vol.9, pp.25-27, 2013. https://doi.org/10.1016/j.nano.2012.09.001
  12. S. McMahon, M. Mendenhall, and S. Jain, "Radiotherapy in the presence of contrast agents: a general figure of merit and its application to gold nanoparticle," Phys. Med. Biol., Vol.53, pp.5635-5651, 2008. https://doi.org/10.1088/0031-9155/53/20/005
  13. K. T. Butterworth, J. A. Coulter, and S. Jain, "Evaluation of cytotoxicity and radiation enhancement using 1.9 nm gold particles: potential application for cancer therapy," Nanotechnology, Vol.21, pp.295101, 2010. https://doi.org/10.1088/0957-4484/21/29/295101
  14. S. Jain, D. G. Hirst, and J. M. O'Sullivan, "Gold nanoparticles as novel agents for cancer therapy," Br J Radiol, Vol.85, pp.101-13, 2012. https://doi.org/10.1259/bjr/59448833
  15. K. Micheal, C. James, and B. C. Devika, "Irradiation of gold nanoparticles by x-rays: Monte Carlo simulation of dose enhancements and the spatial properties of the secondary electron production," Med. Phys., Vol.38, pp.624-631, 2011. https://doi.org/10.1118/1.3539623
  16. D. B. Chithrani, D. B. Jelveh, S and F. Jalali, "Gold nanoparticles as radiation sensitizers in cancer therapy," Radiat Res., Vol.173, pp.719-728, 2010. https://doi.org/10.1667/RR1984.1
  17. 박주경, 이승훈, 차석용, 이선영, "간외 담도암 고선량률 관내근접방사선치료 시 몬테카롤로 시뮬레이션을 통한 주변장기의 선량평가 연구," 한국콘텐츠학회논문지, Vol.14, No.2, pp.467-474, 2014.
  18. W. S. Snyder, H. L. Fisher Jr, M. R. Ford, and G. G. Warner, "Estimates for Absorbed Fractions for Monoenergetic Photon Sources Uniformly Distributed in Various Organs of a Heterogeneous Phantom," Journal of Nuclear Medicine, Vol.47, 1969.
  19. O. K. Harling, R. G. Zamenhof, and J. A. Bernard, "Monte Carlo based dosimetry and treatment planning for neutron capture therapy of brain tumors, in neutron beam design, development and performance for neutron capture therapy," Plenum, New York, pp.283-305, 1990.
  20. ICRU Report 46, Photon, electron, proton, and neutron interaction data for body tissues. International Committee on Radiation Units and Measurements, Bethesda, MD, 1992.
  21. A. Baumgartner, A. Steurer, and F. Maringer, "Simulation of photon energy spectra from Varian 2100C and 2300C/D Linacs: Simplified estimates with PENELOPE Monte Carlo models," Applied Radiation and Isotopes, Vol.67, pp.2007-2012, 2009. https://doi.org/10.1016/j.apradiso.2009.07.010
  22. D. B. Pelowitz, MCNPX user's manual 2.7.0. LANL Report LA-CP-11-00438, Los Alamos National Laboratory, 2011.
  23. J. Chow, M. Leung, and D. Jaffray, "Monte carlo simulation on a gold nanoparticle irradiated by electron beams," Physics in Medicine and Biology, Vol.57, pp.3323-3331, 2012. https://doi.org/10.1088/0031-9155/57/11/3323
  24. N. Ramesh and S. Sharma, "Dose enhancement in gold nanoparticle-aided radiotherapy for the therapeutic photon beams using Monte Carlo technique," Journal of Cancer Research and Therapeutics, Vol.11, pp.94-97, 2011.
  25. K. T. Butterworth, S. J. Mcmacho, and L. E. Taggart, "Radiosensitization by gold nanoparticles: effective at megavoltage energies and potential role of oxidative stress," Transl Cancer Res, Vol.2, pp.269-279, 2013.
  26. Faiz M. Khan, The physics of radiation therapy, Fourth edition, Wolters Kluwer Lippincott Williams & Wilkins.
  27. S. J. McMahon, M. H. Mendenhal, and S. Jain, "Radiotherapyin the presence of contrast agents: a general figure of merit and its application to gold nanoparticle," Phys Med Biol, Vol.53, pp.5635-5651, 2008. https://doi.org/10.1088/0031-9155/53/20/005
  28. N. R. Kakade and S. D. Sharma, "Dose enhancement in gold nanoparticle-aided radiotherapy for the therapeutic photon beams using Monte Carlo technique," Journal of Cancer Research and Therapeutics, Vol.11, pp.94-97, 2015. https://doi.org/10.4103/0973-1482.147691
  29. A. Mesbahi, F. Jamali, and N. Gharehaghaji, "Effect of photon beam energy, gold nanoparticle size and concentration on the dose enhancement in radiation therapy," BioImpacts, Vol.3, pp.29-35, 2013.
  30. D. B. Chithani, S. Jelveh, and F. Jalali, "Gold nanoparticles as radiation sensitizers in cancer therapy," Radiat Res, Vol.173, pp.719-728, 2010. https://doi.org/10.1667/RR1984.1