DOI QR코드

DOI QR Code

The effects of high-fat diet on implant osseointegration: an experimental study

  • Dundar, Serkan (Department of Periodontology, Faculty of Dentistry, Firat University) ;
  • Yaman, Ferhan (Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Dicle University) ;
  • Ozupek, Muhammed Fatih (Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Inonu University) ;
  • Saybak, Arif (Periodontists) ;
  • Gul, Mehmet (Department of Periodontology, Faculty of Dentistry, Dicle University) ;
  • Asutay, Fatih (Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Afyon Kocatepe University) ;
  • Kirtay, Mustafa (Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Inonu University) ;
  • Ozercan, Ibrahim Hanifi (Department of Medical Pathology, Faculty of Medicine, Firat University)
  • Received : 2016.02.08
  • Accepted : 2016.05.04
  • Published : 2016.08.31

Abstract

Objectives: In this study, we investigated whether a high-fat diet (HFD) affected the bone implant connection (BIC) in peri-implant bone. Materials and Methods: Four male rabbits were used in this study. Dental implant surgery was introduced into each tibia, and four implants were integrated into each animal. In both the normal diet (ND) group (n=2) and HFD group (n=2), 8 implants were integrated, for a total of 16 integrated implants. The animals continued with their respective diets for 12 weeks post-surgery. Afterward, the rabbits were sacrificed, and the BIC was assessed histomorphometrically. Results: Histologic and histomorphometric analyses demonstrated that BIC was not impaired in the HFD group compared to the ND group. Conclusion: Within the limitations of this study, we found that HFD did not decrease the BIC in rabbit tibias.

Keywords

References

  1. Pirih F, Lu J, Ye F, Bezouglaia O, Atti E, Ascenzi MG, et al. Adverse effects of hyperlipidemia on bone regeneration and strength. J Bone Miner Res 2012;27:309-18. https://doi.org/10.1002/jbmr.541
  2. Tintut Y, Morony S, Demer LL. Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivo. Arterioscler Thromb Vasc Biol 2004;24:e6-10. https://doi.org/10.1161/01.ATV.0000112023.62695.7f
  3. Brodeur MR, Brissette L, Falstrault L, Ouellet P, Moreau R. Influence of oxidized low-density lipoproteins (LDL) on the viability of osteoblastic cells. Free Radic Biol Med 2008;44:506-17. https://doi.org/10.1016/j.freeradbiomed.2007.08.030
  4. Boukhris R, Becker KL. Calcification of the aorta and osteoporosis. A roentgenographic study. JAMA 1972;219:1307-11. https://doi.org/10.1001/jama.1972.03190360019005
  5. Halade GV, El Jamali A, Williams PJ, Fajardo RJ, Fernandes G. Obesity-mediated inflammatory microenvironment stimulates osteoclastogenesis and bone loss in mice. Exp Gerontol 2011;46:43-52. https://doi.org/10.1016/j.exger.2010.09.014
  6. Nunez NP, Carpenter CL, Perkins SN, Berrigan D, Jaque SV, Ingles SA, et al. Extreme obesity reduces bone mineral density: complementary evidence from mice and women. Obesity (Silver Spring) 2007;15:1980-7. https://doi.org/10.1038/oby.2007.236
  7. Laurila A, Cole SP, Merat S, Obonyo M, Palinski W, Fierer J, et al. High-fat, high-cholesterol diet increases the incidence of gastritis in LDL receptor-negative mice. Arterioscler Thromb Vasc Biol 2001;21:991-6. https://doi.org/10.1161/01.ATV.21.6.991
  8. Navab M, Hama SY, Anantharamaiah GM, Hassan K, Hough GP, Watson AD, et al. Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3. J Lipid Res 2000;41:1495-508.
  9. Muluke M, Gold T, Kiefhaber K, Al-Sahli A, Celenti R, Jiang H, et al. Diet-induced obesity and its differential impact on periodontal bone loss. J Dent Res 2016;95:223-9. https://doi.org/10.1177/0022034515609882
  10. Ning B, Wang X, Yu Y, Waqar AB, Yu Q, Koike T, et al. High-fructose and high-fat diet-induced insulin resistance enhances atherosclerosis in Watanabe heritable hyperlipidemic rabbits. Nutr Metab (Lond) 2015;12:30. https://doi.org/10.1186/s12986-015-0024-3
  11. Donath K, Breuner G. A method for the study of undecalcified bones and teeth with attached soft tissues. The Sage-Schliff (sawing and grinding) technique. J Oral Pathol 1982;11:318-26. https://doi.org/10.1111/j.1600-0714.1982.tb00172.x
  12. Wang D, Kunzel A, Golubovic V, Mihatovic I, John G, Chen Z, et al. Accuracy of peri-implant bone thickness and validity of assessing bone augmentation material using cone beam computed tomography. Clin Oral Investig 2013;17:1601-9. https://doi.org/10.1007/s00784-012-0841-y
  13. Tresguerres IF, Clemente C, Blanco L, Khraisat A, Tamimi F, Tresguerres JA. Effects of local melatonin application on implant osseointegration. Clin Implant Dent Relat Res 2012;14:395-9. https://doi.org/10.1111/j.1708-8208.2010.00271.x
  14. Lu XM, Zhao H, Wang EH. A high-fat diet induces obesity and impairs bone acquisition in young male mice. Mol Med Rep 2013;7:1203-8. https://doi.org/10.3892/mmr.2013.1297
  15. Waqar AB, Koike T, Yu Y, Inoue T, Aoki T, Liu E, et al. High-fat diet without excess calories induces metabolic disorders and enhances atherosclerosis in rabbits. Atherosclerosis 2010;213:148-55. https://doi.org/10.1016/j.atherosclerosis.2010.07.051
  16. Ozaki MR, de Almeida EA. Evolution and involution of atherosclerosis and its relationship with vascular reactivity in hypercholesterolemic rabbits. Exp Toxicol Pathol 2013;65:297-304. https://doi.org/10.1016/j.etp.2011.09.006
  17. Graham LS, Tintut Y, Parhami F, Kitchen CM, Ivanov Y, Tetradis S, et al. Bone density and hyperlipidemia: the T-lymphocyte connection. J Bone Miner Res 2010;25:2460-9. https://doi.org/10.1002/jbmr.148
  18. Parhami F. Possible role of oxidized lipids in osteoporosis: could hyperlipidemia be a risk factor? Prostaglandins Leukot Essent Fatty Acids 2003;68:373-8. https://doi.org/10.1016/S0952-3278(03)00061-9
  19. Rajamannan NM. Low-density lipoprotein and aortic stenosis. Heart 2008;94:1111-2. https://doi.org/10.1136/hrt.2007.130971
  20. Lac G, Cavalie H, Ebal E, Michaux O. Effects of a high fat diet on bone of growing rats. Correlations between visceral fat, adiponectin and bone mass density. Lipids Health Dis 2008;7:16. https://doi.org/10.1186/1476-511X-7-16
  21. Keuroghlian A, Barroso AD, Kirikian G, Bezouglaia O, Tintut Y, Tetradis S, et al. The effects of hyperlipidemia on implant osseointegration in the mouse femur. J Oral Implantol 2015;41:e7-11. https://doi.org/10.1563/AAID-JOI-D-13-00105
  22. Parhami F, Tintut Y, Beamer WG, Gharavi N, Goodman W, Demer LL. Atherogenic high-fat diet reduces bone mineralization in mice. J Bone Miner Res 2001;16:182-8. https://doi.org/10.1359/jbmr.2001.16.1.182
  23. Hirasawa H, Tanaka S, Sakai A, Tsutsui M, Shimokawa H, Miyata H, et al. ApoE gene deficiency enhances the reduction of bone formation induced by a high-fat diet through the stimulation of p53-mediated apoptosis in osteoblastic cells. J Bone Miner Res 2007;22:1020-30. https://doi.org/10.1359/jbmr.070330
  24. Sage AP, Lu J, Atti E, Tetradis S, Ascenzi MG, Adams DJ, et al. Hyperlipidemia induces resistance to PTH bone anabolism in mice via oxidized lipids. J Bone Miner Res 2011;26:1197-206. https://doi.org/10.1002/jbmr.312
  25. Jie KG, Bots ML, Vermeer C, Witteman JC, Grobbee DE. Vitamin K status and bone mass in women with and without aortic atherosclerosis: a population-based study. Calcif Tissue Int 1996;59:352-6. https://doi.org/10.1007/s002239900139

Cited by

  1. Effects of Different Levels of Restraint Stress on Bone-Implant Contact : vol.30, pp.4, 2016, https://doi.org/10.1097/scs.0000000000005104
  2. Hyperlipidemia Impairs Osseointegration via the ROS/Wnt/β-Catenin Pathway vol.100, pp.6, 2016, https://doi.org/10.1177/0022034520983245
  3. Pre-Clinical Models in Implant Dentistry: Past, Present, Future vol.9, pp.11, 2016, https://doi.org/10.3390/biomedicines9111538