Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
권호 표지
DOI QR코드

DOI QR Code

A novel nicotinoyl peptide, nicotinoyl-LVH, for collagen synthesis enhancement in skin cells

  • Received : 2016.04.26
  • Accepted : 2016.06.07
  • Published : 2016.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

A novel Nicotinoyl fused peptide, Nicotinoyl-LVH, was synthesized by solid phase peptide synthesis method, purified, and tested in cultured skin cells. Nicotinoyl-LVH enhanced the expression level of collagen mRNA and its fragments in fibroblasts. These data show that this novel Nicotinoyl peptide is a promising biomaterial in the anti-aging functional cosmetic market.

Keywords

References

  1. Benavente CA, Jacobson MK, Jacobson EL (2009) NAD in skin: therapeutic approaches for niacin. Curr Pharm Des 15: 29-38 https://doi.org/10.2174/138161209787185760
  2. Cantarella L, Gallifuoco A, Malandra A, Martinkova L, Spera A, Cantarella M (2011) High-yield continuous production of nicotinic acid via nitrile hydratase-amidase cascade reactions using cascade CSMRs. Enzyme Microbial Technology 48: 345-350 https://doi.org/10.1016/j.enzmictec.2010.12.010
  3. Francini G, Gonnelli S, Petrioli R, Bruni S, Marsili S, Aquino A, Camporeale A (1993) Procollagen type I carboxy-terminal propeptide as a marker of osteoblastic bone metastases. Cancer Epidemiol Biomarkers Prev 2: 125-129
  4. Ganceviciene R, Liakou A, Theodoridis A, Makrantonaki E, Zouboulis CC (2012) Skin anti-aging strategies. Dermatoendocrinol 4: 308-319 https://doi.org/10.4161/derm.22804
  5. Gieldanowski J, Kowalczyk-Bronisz SH, Blaszczyk B (1987) Pharmacological investigations on anti-inflammatory activity of tryptamide (3-nicotinoyltryptamine). Pol J Pharmacol Pharm 39: 759-767
  6. Ishii N, Nishihara Y (1981) Pellagra among chronic alcoholics: clinical and pathological study of 20 necropsy cases. J Neurol Neurosurg Psychiatry 44: 209-215 https://doi.org/10.1136/jnnp.44.3.209
  7. Kim B, Hwang JS, Kim HS (2015) N-Nicotinoyl dopamine inhibits skin pigmentation by suppressing of melanosome transfer. Eur J Pharmacol 769: 250-256 https://doi.org/10.1016/j.ejphar.2015.11.025
  8. Kim B, Kim JE, Lee SM, Lee SH, Lee JW, Kim MK, Lee JD, Chio KY (2011) N-Nicotinoyl dopamine, a novel niacinamide derivative, retains high antioxidant activity and inhibits skin pigmentation. Exp Dermatol 20: 950-952 https://doi.org/10.1111/j.1600-0625.2011.01345.x
  9. Masamune A, Hamada S, Kikuta K, Takikawa T, Miura S, Nakano E, Shimosegawa T (2013) The angiotensin II type I receptor blocker olmesartan inhibits the growth of pancreatic cancer by targeting stellate cell activities in mice. Scand J Gastroenterol 48: 602-609 https://doi.org/10.3109/00365521.2013.777776
  10. Prakash R, Gandotra S, Singh LK, Das B, Lakra A (2008) Rapid resolution of delusional parasitosis in pellagra with niacin augmentation therapy. Gen Hosp Psychiatry 30: 581-584 https://doi.org/10.1016/j.genhosppsych.2008.04.011
  11. Uttekar MM, Das T, Pawar RS, Bhandari B, Menon V, Nutan, Gupta SK, Bhat SV (2012) Anti-HIV activity of semisynthetic derivatives of andrographolide and computational study of HIV-1 gp120 protein binding. Eur J Med Chem 56: 368-374 https://doi.org/10.1016/j.ejmech.2012.07.030
  12. Wan P, Moat S, Anstey A (2011) Pellagra: a review with emphasis on photosensitivity. Br J Dermatol 164: 1188-1200 https://doi.org/10.1111/j.1365-2133.2010.10163.x