Journal of Korean Ophthalmic Optics Society (한국안광학회지)

The Korean Ophthalmic Optics Society (한국안광학회)
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Relationship between the Deposition of Tear Constituents and the Adherence of Candida albicans according to Soft Contact Lens Materials and Pigmentation

소프트콘택트렌즈 재질과 착색에 따른 눈물성분 침착과 칸디다균 흡착의 상관관계

  • Park, So Hyun (Dept. of Optometry, Seoul National University of Science and Technology) ;
  • Kim, So Ra (Dept. of Optometry, Seoul National University of Science and Technology) ;
  • Park, Mijung (Dept. of Optometry, Seoul National University of Science and Technology)
  • 박소현 (서울과학기술대학교 안경광학과) ;
  • 김소라 (서울과학기술대학교 안경광학과) ;
  • 박미정 (서울과학기술대학교 안경광학과)
  • Received : 2016.08.17
  • Accepted : 2016.09.07
  • Published : 2016.09.30
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Abstract

Purpose: The aim of this study was to figure out how the characteristics of soft contact lens materials and pigmentation affect the adherence of C. albicans on soft contact lenses pre-deposited with tear constituents. Methods: The adherent number of C. albicans on clear soft contact lenses (hereinafter clear lenses) and circle soft contact lenses (hereinafter circle lenses) made of etafilcon A, hilaiflcon B and nelfilcon A, respectively, was measured before and after the deposition of artificial tear. Also, bacteria adherence on lenses were observed by a scanning electron microscope. Results: Adherence of C. albicans was significantly different according to lens materials. The amount of adsorption was not different between clear lenses and circle lenses made of etafilcon A however, the number of bacteria absorption was bigger in hilafilcon B and nelfilcon A lenses. More absorption of C. albicans was found in the non-pigmented central area compared the pigmented area, and non-pigmented peripheral area has more bacterial absorption than non-pigmented central area. The number of C. albicans decreased in the case that tear protein was pre-deposited. The maintenance of antibacterial activity against C. albicans was different according to lens materials thus, etafilcon A has the longest period of its maintenance. Conclusions: It was revealed that the number of C. albicans was different according to the characteristics of lens materials, pigmentation or non-pigmentation, the pigmented area of soft contact lenses. Thus, it is suggested that the management method should be different according to the adsorption characteristics of C. albicans.

목적: 본 연구에서는 소프트콘택트렌즈의 재질 특성과 착색 여부가 눈물 성분이 침착된 소프트콘택트렌즈에 칸디다균 흡착에 미치는 영향을 알아보았다. 방법: Etafilcon A, hilafilcon B, nelfilcon A 재질의 투명 소프트콘택트렌즈와 써클 소프트콘택트렌즈를 대상으로 하여 인공눈물에 침착시키기 전과 후의 흡착 균 수를 측정하였다. 또한, 주사전자현미경을 통해 렌즈에 흡착된 균을 관찰하였다. 결과: 칸디다균의 흡착은 콘택트렌즈 재질에 따라 통계적으로 유의하게 차이가 있었다. Etafilcon A 재질에서는 투명 소프트콘택트렌즈와 써클 콘택트렌즈간 균 흡착양 차이가 없었으며, hilafilcon B 및 nelfilcon A 재질에서는 써클 소프트콘택트렌즈에 흡착된 균 수가 다소 많았다. 투명 중심부와 착색부를 비교하였을 때 투명 중심부에 칸디다균 흡착이 더 많았으며, 투명 중심부와 투명 주변부를 비교하였을 때 투명 주변부에서의 균 흡착양이 더 많았다. 눈물 단백질이 침착되었을 경우 흡착된 칸디다균의 수가 감소하였으며 눈물 단백질의 칸디다균에 대한 항균력 유지는 재질에 따라 차이가 있어 etafilcon A 재질 렌즈에서 유지 기간이 가장 길었다. 결론: 본 연구에서는 소프트콘택트렌즈의 재질 특성, 착색여부 및 부위에 따라 흡착되는 칸디다균수가 달라진다는 것을 밝혔으며, 칸디다균의 흡착 특성에 따라 관리 방법을 달리해야 할 것을 제안한다.

Keywords

References

  1. Korean Optometric Association. Gallup Korea : National contact lens utilization in the first half of 2015, 2015. http://www.optic.or.kr/Cate_03/eOpticnews.asp?nmode=view&OnsSeq=2686&search_type=4(02 December 2015).
  2. Ruben M, Guillon M. Contact lens practice, 1st Ed. London: Chapman & Hall, 1994:667-720.
  3. Jung MA, Lee HJ. Survey on cosmetic color contact lens wear status of middle school, high school and college students. Korean J Vis Sci. 2013;15(4):439-446.
  4. Quinn MH, Atkins BL. Pearlecent contact lens. U.S. Patent 6196683, 2001.
  5. Lee HM, Kim JK, Cho TS. Antimicrobial hydrogel contact lens containing alginate. Bull Korean Chem Soc. 2011;32(12):4239-4243. https://doi.org/10.5012/bkcs.2011.32.12.4239
  6. Lee S, Park M, Kim SR. The difference in tear film stability between normal and dry eyes by wearing clear and circle contact lenses made of the same materials. J Korean Ophthalmic Opt Soc. 2016;21(1):11-21. https://doi.org/10.14479/jkoos.2016.21.1.11
  7. OnurdagFK, Ozkan S, Ozgen S, OlmusH, Abbasoglu U. Candida albicans and Pseudomonas aeruginosa adhesion on soft contact lenses. Graefes Arch Clin Exp Ophthalmol. 2011;249(4):559-564. https://doi.org/10.1007/s00417-010-1595-3
  8. Giraldez MJ, Resua CG, Lira M, Oliveira ME, Magarinos B, Toranzo AE et al. Contact lens hydrophobicity and roughness effects on bacterial adhesion. Optom Vis Sci. 2010;87(6):E426-E431.
  9. Chan KY, Cho P, Boost M. Microbial adherence to cosmetic contact lenses. Cont Lens Anterior Eye. 2014;37(4):267-272. https://doi.org/10.1016/j.clae.2013.12.002
  10. Suwala M, Glasier MA, Subbaraman LN, Jones L. Quantity and conformation of lysozyme deposited on conventional and silicone hydrogel contact lens materials using an in vitro model. Eye Contact Lens. 2007;33(3):138-143. https://doi.org/10.1097/01.icl.0000244155.87409.f6
  11. Sariri R, Tighe B. Effect of surface chemistry on protein interaction with hydrogel contact lenses. Iran Polym J. 1996;5(4):259-266.
  12. Norde W. Adsorption of proteins from solution at the solid-liquid interface. Adv Colloid Interface Sci. 1986;25(4):267-340. https://doi.org/10.1016/0001-8686(86)80012-4
  13. Subbaraman LN, Borazjani R, Zhu H, Zhao Z, Jones L, Willcox MD. Influence of protein deposition on bacterial adhesion to contact lenses. Optom Vis Sci. 2011;88(8):959-966. https://doi.org/10.1097/OPX.0b013e31821ffccb
  14. Lee JS, Hahn TW, Choi SH, Yu HS, Lee JE. Acanthamoeba keratitis related to cosmetic contact lenses. Clin Exp Ophthalmol. 2007;35(8):775-777. https://doi.org/10.1111/j.1442-9071.2007.01622.x
  15. Bucci FA Jr, Evans RE, Moody KJ, Tanner JB, Capozza RC, Klyce SD. The annular tinted contact lens syndrome: corneal topographic analysis of ring-shaped irregular astigmatism caused by annular tinted contact lenses. CLAO J. 1997;23(3):161-167.
  16. Spraul CW, Roth HJ, Gackle H, Lang GE, Lang GK. Influence of special-effect contact lenses (Crazy Lenses) on visual function. CLAO J. 1998;24(1):29-32.
  17. Kim SR, Kang U, Seo BM, Park M. A study on dye elution from the circle contact lenses. J Korean Ophthalmic Opt Soc. 2014;19(2):171-177. https://doi.org/10.14479/jkoos.2014.19.2.171
  18. Spiteri N, Choudhary A, Kaye S. Pigmentation of the cornea secondary to tinted soft contact lens wear. Case Rep Ophthalmol Med. 2012;2012:852304.
  19. Korean contact lens study society. Contact lens: principles and practice, 1st Ed. Seoul: Naeoe Hanksool, 2007; chap 13.
  20. Lorenz KO, Kakkassery J, Boree D, Pinto D. Atomic force microscopy and scanning electron microscopy analysis of daily disposable limbal ring contact lenses. Clin Exp Optom. 2014;97(5):411-417. https://doi.org/10.1111/cxo.12148
  21. The Korea Optical News. The evolution of cosmetic lenses as a technology of contact lenses, 2014. http://www.opticnews.co.kr/news/articleView.html?idxno=24319 (19 December 2014).
  22. Baguet J, Sommer F, Claudon-Eyl V, Duc TM. Characterization of lacrymal component accumulation on worn soft contact lens surfaces by atomic force microscopy. Biomaterials. 1995;16(1):3-9. https://doi.org/10.1016/0142-9612(95)91089-H
  23. Bruinsma GM, Rustema-Abbing M, de Vries J, Stegenga B, van der Mei HC, van der Linden ML et al. Influence of wear and overwear on surface properties of etafilcon A contact lenses and adhesion of Pseudomonas aeruginosa. Invest Ophthalmol Vis Sci. 2002;43(12):3646-3653.
  24. Park SH, Park IS, Kim SR, Park M. Relationship between the deposition of tear constituents on soft contact lenses according to material and pigmentation and adherence of Staphylococcus aureus. J Korean Ophthalmic Opt Soc. 2016;21(2):109-117. https://doi.org/10.14479/jkoos.2016.21.2.109
  25. Health Chosun. USA, Fungal infections emergency of contact lens users, 2006. http://health.chosun.com/site/data/html_dir/2006/04/12/2006041256005.html(12 April 2016).
  26. Medical Observer. Fungal infections emergency of contact lens, 2006. http://www.monews.co.kr/news/articleView.html?idxno=9609(12 April 2016).
  27. Galentine PG, Cohen EJ, Laibson PR, Adams CP, Michaud R, Arentsen JJ. Corneal ulcers associated with contact lens wear. Arch Ophthalmol. 1984;102(6):891-894. https://doi.org/10.1001/archopht.1984.01040030711025
  28. Park M, Kwon MJ, Hyun SH, Kim DS. The adsorption pattern of protein to the soft contact lens and its effect on the visible light transmission and the contact angle. Korean Ophthalmic Opt Soc. 2004;9(1):53-68.
  29. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193(1):265-275.
  30. Onurdag FK, Ozkan S, Ozgen S, Olmus H, Abbasoglu U. Candida albicans and Pseudomonas aeruginosa adhesion on soft contact lenses. Graefes Arch Clin Exp Ophthalmol. 2011;249(4):559-564. https://doi.org/10.1007/s00417-010-1595-3
  31. Imamura Y, Chandra J, Mukherjee PK, Lattif AA, Szczotka-Flynn LB, Pearlman E et al. Fusarium and Candida albicans biofilms on soft contact lenses: model development, influence of lens type, and susceptibility to lens care solutions. Antimicrob Agents Chemother. 2008;52(1):171-182. https://doi.org/10.1128/AAC.00387-07
  32. Simmons RB, Buffington JR, Ward M, Wilson LA, Ahearn DG. Morphology and ultrastructure of fungi in extended-wear soft contact lenses. J Clin Microbiol. 1986;24(1):21-25.
  33. Fleming A. On a remarkable bacteriolytic element found in tissues and secretions. Proc Roy Soc. 1922;93(653):306-317. https://doi.org/10.1098/rspb.1922.0023
  34. Leitch EC, Willcox MD. Lactoferrin increases the susceptibility of S. epidermidis biofilms to lysozyme and vancomycin. Curr Eye Res. 1999;19(1):12-19. https://doi.org/10.1076/ceyr.19.1.12.5342
  35. Tobgi RS, Samaranayake LP, MacFarlane TW. In vitro susceptibility of Candida species to lysozyme. Oral Microbiol Immunol. 1988;3(1):35-39. https://doi.org/10.1111/j.1399-302X.1988.tb00603.x
  36. Samaranayake YH, Samaranayake LP, Wu PC, So M. The antifungal effect of lactoferrin and lysozyme on Candida krusei and Candida albicans. APMIS. 1997;105(11):875-883. https://doi.org/10.1111/j.1699-0463.1997.tb05097.x
  37. Fukazawa Y, Shinoda T, Tsuchiya T. Response and specificity of antibodies for Candida albicans. J Bacteriol. 1968;95(3):754-763.
  38. Giraldez MJ, Yebra-Pimentel E. Hydrogel contact lens surface roughness and bacterial adhesion. INTECH Open Access Publisher, 2012;95-120.
  39. Ji YW, Cho YJ, Lee CH, Hong SH, Chung DY, Kim EK et al. Comparison of surface roughness and bacterial adhesion between cosmetic contact lenses and conventional contact lenses. Eye Contact Lens. 2015;41(1):25-33. https://doi.org/10.1097/ICL.0000000000000054

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