Journal of Ginseng Research

  • 제40권4호
  • /
  • Pages.445-452
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  • 2016
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  • 1226-8453(pISSN)
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  • 2093-4947(eISSN)
고려인삼학회 (The Korean Society of Ginseng)
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Morphine dependence is attenuated by red ginseng extract and ginsenosides Rh2, Rg3, and compound K

  • Yayeh, Taddesse (Department of Molecular Medicine, School of Medicine, Ewha Womans University) ;
  • Yun, Kyunghwa (Department of Molecular Medicine, School of Medicine, Ewha Womans University) ;
  • Jang, Soyong (Department of Molecular Medicine, School of Medicine, Ewha Womans University) ;
  • Oh, Seikwan (Department of Molecular Medicine, School of Medicine, Ewha Womans University)
  • 투고 : 2016.05.27
  • 심사 : 2016.08.12
  • 발행 : 2016.10.15
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초록

Background: Red ginseng and ginsenosides have shown plethoric effects against various ailments. However, little is known regarding the effect of red ginseng on morphine-induced dependence and tolerance. We therefore investigated the effect of red ginseng extract (RGE) and biotransformed ginsenosides Rh2, Rg3, and compound K on morphine-induced dependence in mice and rats. Methods: While mice were pretreated with RGE and then morphine was injected intraperitoneally, rats were infused with ginsenosides and morphine intracranially for 7 days. Naloxone-induced morphine withdrawal syndrome was estimated and conditioned place preference test was performed for physical and psychological dependence, respectively. Western blotting was used to measure protein expressions. Results: Whereas RGE inhibited the number of naloxone-precipitated jumps and reduced conditioned place preference score, it restored the level of glutathione in mice. Likewise, ginsenosides Rh2, Rg3, and compound K attenuated morphine-dependent behavioral patterns such as teeth chattering, grooming, wet-dog shake, and escape behavior in rats. Moreover, activated N-methyl-D-aspartate acid receptor subunit 1 and extracellular signal-regulated kinase in the frontal cortex of rats, and cultured cortical neurons from mice were downregulated by ginsenosides Rh2, Rg3, and compound K despite their differential effects. Conclusion: RGE and biotransformed ginsenosides could be considered as potential therapeutic agents against morphine-induced dependence.

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  1. The Effects of Ginsenoside Compound K Against Epilepsy by Enhancing the γ-Aminobutyric Acid Signaling Pathway vol.9, pp.None, 2018, https://doi.org/10.3389/fphar.2018.01020
  2. An L213A variant of β-glycosidase from Sulfolobus solfataricus with increased α-L-arabinofuranosidase activity converts ginsenoside Rc to compound K vol.13, pp.1, 2016, https://doi.org/10.1371/journal.pone.0191018
  3. Morphine Dependence is Attenuated by Treatment of 3,4,5-Trimethoxy Cinnamic Acid in Mice and Rats vol.44, pp.4, 2019, https://doi.org/10.1007/s11064-019-02720-9
  4. Clinical and Imaging Study of Repetitive Transcranial Magnetic Stimulation in the Treatment of Morphine Dependence Through mGluR5/TDP43/NR2B Pathway vol.2021, pp.None, 2016, https://doi.org/10.1155/2021/6733963