한국산학기술학회논문지 (Journal of the Korea Academia-Industrial cooperation Society)

  • 제17권9호
  • /
  • Pages.57-67
  • /
  • 2016
  • /
  • 1975-4701(pISSN)
  • /
  • 2288-4688(eISSN)
한국산학기술학회 (The Korea Academia-Industrial cooperation Society)
권호 표지
DOI QR코드

DOI QR Code

한국인의 비타민 D 수준에 따른 페리틴, 헤모글로빈 농도: 제4기, 제5기 (2008~2012) 국민건강영양조사

Ferritin and hemoglobin level of korean according to vitamin D state: The Korean National Health and Nutrition Examination Survey IV, V (2008~2012)

  • 투고 : 2016.06.24
  • 심사 : 2016.09.09
  • 발행 : 2016.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

본 연구는 제 4기, 제 5기 국민건강영양조사 자료를 이용하여 18세 이상 성인 23577 명을 남성 전체와 여성 전체, 65세 이상 남성과 65세 미만 남성, 폐경 전 여성과 폐경 후 여성으로 나누어 비타민 D의 수준에 따라 헤모글로빈과 페리틴 농도의 변화가 어떤 차이를 보이는지 알아보고자 하였다. 각 조사 대상 군을 비타민 D의 수준에 따라 5분 위수로 나누어 각 군 별 헤모글로빈과 페리틴 농도의 변화를 복합표본설계방법에 따라 일반선형모형을 사용하여 분석하였고 분석 결과 여성 전체 군(p<0.001)과 폐경 전 여성 군(p<0.001)에서 비타민 D 수준에 따라 헤모글로빈 농도의 차이가 통계적으로 유의하였고 폐경 후 여성 군과 남성 전체 및 65세 이상 남성, 65세 미만 남성 군에서는 통계적으로 유의하지 않았다. 페리틴 농도는 여성 전체 군(p<0.001)과 폐경 전 여성 군(p<0.001)과 남성 전체 군(p<0.05), 65세 미만 남성 군(p<0.05))에서 통계적으로 유의한 차이를 나타냈으나 남성에서 비타민 D가 높은 그룹이 페리틴이 낮았던 반면 여성에서는 비타민 D가 높은 그룹이 페리틴 농도가 더 높았고, 폐경 후 여성 군과 65세 이상 군에서 통계적으로 유의하지 않았다. 따라서 비타민 D는 폐경 전 여성에서 헤모글로빈 농도에 영향을 줄 가능성이 있고 폐경 전 여성과 65세 미만 남성의 체내 철 조절에 관여할 가능성이 있다.

This study is designed to investigate the differences of ferritin and hemoglobin levels according to the vitamin D state in 23577 Korean adult subjects by using data from the Korea National Health and Nutrition Examination Survey IV, V. Ferritin and hemoglobin levels are analyzed based on the quintile of vitamin D levels by a generalized linear model. The results of analysis showed that there was a relationship between vitamin D state and hemoglobin levels in females in the reproductive status group (p<0.001). In case of ferritin, there was a relationship with vitamin D state in females in reproductive status group (p<0.001) and males under 65 years old group (p<0.05). Within the male group, high ferritin correlated with low vitamin D state; but in the female group, high ferritin correlated with high vitamin D state. Therefore, it is possible for the ferritin level to be affected by vitamin D state in females in reproductive status group and males under 65 years old group.

키워드

참고문헌

  1. N. J. Kassebaum, R. Jasrasaria, M. Naghavi, S. K. Wulf, N. Johns, et al., "A systematic analysis of global anemia burden from 1990 to 2010", Blood, vol. 123, no. 5, pp. 615-624, Jan 30 2014. DOI: http://dx.doi.org/10.1182/blood-2013-06-508325
  2. S. K. Kim, H. S. Kang, C. S. Kim, Y. T. Kim, "The prevalence of anemia and iron depletion in the population aged 10 years or older", Korean J.Hematol., vol. 46, no. 3, pp. 196-199, Sep 2011. DOI: http://dx.doi.org/10.5045/kjh.2011.46.3.196
  3. B. W. Penninx, M. Pahor, M. Cesari, A. M. Corsi, R. C. Woodman, et al., "Anemia is associated with disability and decreased physical performance and muscle strength in the elderly", J.Am.Geriatr.Soc., vol. 52, no. 5, pp. 719-724, May 2004. DOI: http://dx.doi.org/10.1111/j.1532-5415.2004.52208.x
  4. M. B. Zimmermann, R. F. Hurrell, "Nutritional iron deficiency", Lancet, vol. 370, no. 9586, pp. 511-520, Aug 11 2007. DOI: http://dx.doi.org/10.1016/S0140-6736(07)61235-5
  5. D. D. Bikle, "Vitamin D metabolism, mechanism of action, and clinical applications", Chem.Biol., vol. 21, no. 3, pp. 319-329, Mar 20 2014. DOI: http://dx.doi.org/10.1016/j.chembiol.2013.12.016
  6. J. Y. Shin, J. Y. Shim, "Low vitamin D levels increase anemia risk in Korean women", Clin.Chim.Acta, vol. 421, pp. 177-180, Jun 5 2013. DOI: http://dx.doi.org/10.1016/j.cca.2013.02.025
  7. S. S. Han, M. Kim, H. Kim, S. M. Lee, Y. J. Oh, et al., "Non-linear relationship between serum 25-hydroxyvitamin D and hemoglobin in Korean females: the Korean National Health and Nutrition Examination Survey 2010-2011", PLoS One, vol. 8, no. 8, pp. e72605, Aug 28 2013. DOI: http://dx.doi.org/10.1371/journal.pone.0072605
  8. J. Golbahar, D. Altayab, E. Carreon, A. Darwish, "Association of vitamin D deficiency and hyperparathyroidism with anemia: a cross-sectional study", J.Blood Med., vol. 4, pp. 123-128, Aug 30 2013. DOI: http://dx.doi.org/10.2147/JBM.S47171
  9. Y. J. Suh, J. E. Lee, D. H. Lee, H. G. Yi, M. H. Lee, et al., "Prevalence and Relationships of Iron Deficiency Anemia with Blood Cadmium and Vitamin D Levels in Korean Women", J.Korean Med.Sci., vol. 31, no. 1, pp. 25-32, Jan 2016. DOI: http://dx.doi.org/10.3346/jkms.2016.31.1.25
  10. V. Hirani, R. G. Cumming, F. Blyth, V. Naganathan, D. G. Le Couteur, et al., "Cross-sectional and longitudinal associations between the active vitamin D metabolite (1,25 dihydroxyvitamin D) and haemoglobin levels in older Australian men: the Concord Health and Ageing in Men Project", Age (Dordr), vol. 37, no. 1, pp. 9749-015-9749-1. Epub 2015 Feb 4, Feb 2015.
  11. C. Kim, B. Nan, S. Kong, S. Harlow, "Changes in iron measures over menopause and associations with insulin resistance", J.Womens Health.(Larchmt), vol. 21, no. 8, pp. 872-877, Aug 2012. DOI: http://dx.doi.org/10.1089/jwh.2012.3549
  12. H. S. Choi, H. J. Oh, H. Choi, W. H. Choi, J. G. Kim, et al., "Vitamin D insufficiency in Korea a greater threat to younger generation: the Korea National Health and Nutrition Examination Survey (KNHANES) 2008," J.Clin.Endocrinol.Metab., vol. 96, no. 3, pp. 643-651, Mar 2011. DOI: http://dx.doi.org/10.1210/jc.2010-2133
  13. S. Hussein, J. Prieto, M. O'Shea, A. V. Hoffbrand, R. A. Baillod, et al., "Serum ferritin assay and iron status in chronic renal failure and haemodialysis", Br.Med.J., vol. 1, no. 5957, pp. 546-548, Mar 8 1975. DOI: http://dx.doi.org/10.1136/bmj.1.5957.546
  14. Report of a WHO scientific group, "Nutritional anaemias", World Health.Organ.Tech.Rep.Ser. vol. 405, pp. 5-37, 1968.
  15. K.D. Pagana, T. J. Pagana. Mosby's Manual of Diagnostic and Laboratory Tests. 4th ed, pp. 380-383, St. Louis: Mosby Elsevier, 2010.
  16. I. Ohki, K. Dan, S. Kuriya, T. Nomura, "A study on the mechanism of anemia and leukopenia in liver cirrhosis," Jpn.J.Med., vol. 27, no. 2, pp. 155-159, May 1988. DOI: http://dx.doi.org/10.2169/internalmedicine1962.27.155
  17. K. U. Eckardt, "Pathophysiology of renal anemia," Clin.Nephrol., vol. 53, no. 1 Suppl, pp. S2-8, Feb 2000.
  18. S. Christakos, D. V. Ajibade, P. Dhawan, A. J. Fechner, L. J. Mady, "Vitamin D: metabolism," Rheum.Dis.Clin.North Am., vol. 38, no. 1, pp. 1-11, vii, Feb 2012. https://doi.org/10.1016/j.rdc.2012.03.003
  19. K. V. Patel, "Epidemiology of anemia in older adults," Semin.Hematol., vol. 45, no. 4, pp. 210-217, Oct 2008. DOI: http://dx.doi.org/10.1053/j.seminhematol.2008.06.006
  20. D. Nordenberg, R. Yip, N. J. Binkin, "The effect of cigarette smoking on hemoglobin levels and anemia screening", JAMA, vol. 264, no. 12, pp. 1556-1559, Sep 26 1990. DOI: http://dx.doi.org/10.1001/jama.264.12.1556
  21. C. G. Kim, "The Relation of BMI, Smoking and Drinking with Biomedical Parameters in 20s and 30s Men", Journal of the Korea Academia-Industrial Cooperation Society Vol. 12, no. 10, pp. 4425-4433, 2011. DOI: http://dx.doi.org/10.5762/KAIS.2011.12.10.4425
  22. I. Blazsek, C. Farabos, P. Quittet, M. L. Labat, A. F. Bringuier, et al., "Bone marrow stromal cell defects and 1 alpha,25-dihydroxyvitamin D3 deficiency underlying human myeloid leukemias", Cancer Detect.Prev., vol. 20, no. 1, pp. 31-42 1996.
  23. A. Icardi, E. Paoletti, L. De Nicola, S. Mazzaferro, R. Russo, et al., "Renal anaemia and EPO hyporesponsiveness associated with vitamin D deficiency: the potential role of inflammation," Nephrol.Dial.Transplant., vol. 28, no. 7, pp. 1672-1679, Jul 2013. DOI: http://dx.doi.org/10.1093/ndt/gft021
  24. F. Aucella, R. P. Scalzulli, G. Gatta, M. Vigilante, A. M. Carella, et al., "Calcitriol increases burst-forming unit-erythroid proliferation in chronic renal failure. A synergistic effect with r-HuEpo", Nephron Clin.Pract., vol. 95, no. 4, pp. c121-7 2003. DOI: http://dx.doi.org/10.1159/000074837
  25. D. B. Alon, C. Chaimovitz, A. Dvilansky, G. Lugassy, A. Douvdevani, et al., "Novel role of 1,25(OH)(2)D(3) in induction of erythroid progenitor cell proliferation," Exp.Hematol., vol. 30, no. 5, pp. 403-409, May 2002. DOI: http://dx.doi.org/10.1016/S0301-472X(02)00789-0
  26. T. Ganz, "Systemic iron homeostasis", Physiol.Rev., vol. 93, no. 4, pp. 1721-1741, Oct 2013. DOI: http://dx.doi.org/10.1152/physrev.00008.2013
  27. T. Ganz, "Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation", Blood, vol. 102, no. 3, pp. 783-788, Aug 1 2003. DOI: http://dx.doi.org/10.1182/blood-2003-03-0672
  28. B. Rostkowska-Nadolska, E. Sliupkas-Dyrda, J. Potyka, D. Kusmierz, M. Fraczek, et al., "Vitamin D derivatives: calcitriol and tacalcitol inhibits interleukin-6 and interleukin-8 expression in human nasal polyp fibroblast cultures", Adv.Med.Sci., vol. 55, no. 1, pp. 86-92 2010. DOI: http://dx.doi.org/10.2478/v10039-010-0012-9
  29. S. M. Zughaier, J. A. Alvarez, J. H. Sloan, R. J. Konrad, V. Tangpricha, "The role of vitamin D in regulating the iron-hepcidin-ferroportin axis in monocytes," J.Clin.Transl.Endocrinol., vol. 1, no. 1, pp. 19-25, Mar 21 2014. https://doi.org/10.1016/j.jcte.2014.01.003
  30. B. Chung, P. Matak, A. T. McKie, P. Sharp, "Leptin increases the expression of the iron regulatory hormone hepcidin in HuH7 human hepatoma cells", J.Nutr., vol. 137, no. 11, pp. 2366-2370, Nov 2007. https://doi.org/10.1093/jn/137.11.2366
  31. C. Menendez, M. Lage, R. Peino, R. Baldelli, P. Concheiro, et al., "Retinoic acid and vitamin D(3) powerfully inhibit in vitro leptin secretion by human adipose tissue", J.Endocrinol., vol. 170, no. 2, pp. 425-431, Aug 2001. DOI: http://dx.doi.org/10.1677/joe.0.1700425
  32. S. Meguro, M. Tomita, T. Katsuki, K. Kato, H. Oh, et al., "Plasma 25-hydroxyvitamin d is independently associated with hemoglobin concentration in male subjects with type 2 diabetes mellitus", Int.J.Endocrinol., vol. 2011, pp. 5, 2011. DOI: http://dx.doi.org/10.1155/2011/362981
  33. J. J. Sim, P. T. Lac, I. L. Liu, S. O. Meguerditchian, V. A. Kumar, et al., "Vitamin D deficiency and anemia: a cross-sectional study", Ann.Hematol., vol. 89, no. 5, pp. 447-452, May 2010. DOI: http://dx.doi.org/10.1007/s00277-009-0850-3
  34. K. M. Spach, C. E. Hayes, "Vitamin D3 confers protection from autoimmune encephalomyelitis only in female mice", J. Immunol., vol. 175, no. 6, pp. 4119-4126, Sep 15 2005. DOI: http://dx.doi.org/10.4049/jimmunol.175.6.4119
  35. J. Kragt, B. van Amerongen, J. Killestein, C. Dijkstra, B. Uitdehaag, et al., "Higher levels of 25-hydroxyvitamin D are associated with a lower incidence of multiple sclerosis only in women", Mult.Scler., vol. 15, no. 1, pp. 9-15, Jan 2009. https://doi.org/10.1177/1352458508095920
  36. J. M. Diez, M. T. Agapito, J. M. Recio, "The effect of estrogens on serum ferritin levels in duck," Rev.Esp.Fisiol., vol. 42, no. 2, pp. 179-183, Jun 1986.
  37. Y. Hou, S. Zhang, L. Wang, J. Li, G. Qu, et al., "Estrogen regulates iron homeostasis through governing hepatic hepcidin expression via an estrogen response element", Gene, vol. 511, no. 2, pp. 398-403, Dec 15 2012. DOI: http://dx.doi.org/10.1016/j.gene.2012.09.060
  38. D. Somjen, "Vitamin D modulation of the activity of estrogenic compounds in bone cells in vitro and in vivo", Crit.Rev.Eukaryot.Gene Expr., vol. 17, no. 2, pp. 115-147 2007. DOI: http://dx.doi.org/10.1615/CritRevEukarGeneExpr.v17.i2.30
  39. J. C. Gallagher, B. L. Riggs, H. F. DeLuca, "Effect of estrogen on calcium absorption and serum vitamin D metabolites in postmenopausal osteoporosis", J.Clin.Endocrinol.Metab., vol. 51, no. 6, pp. 1359-1364, Dec 1980. DOI: http://dx.doi.org/10.1210/jcem-51-6-1359
  40. D. Barrera, E. Avila, G. Hernandez, A. Halhali, B. Biruete, et al., "Estradiol and progesterone synthesis in human placenta is stimulated by calcitriol", J. Steroid Biochem.Mol.Biol., vol. 103, no. 3-5, pp. 529-532, Mar 2007. DOI: http://dx.doi.org/10.1016/j.jsbmb.2006.12.097
  41. J. A. Knight, J. Wong, K. M. Blackmore, J. M. Raboud, R. Vieth, "Vitamin D association with estradiol and progesterone in young women", Cancer Causes Control, vol. 21, no. 3, pp. 479-483, Mar 2010. DOI: http://dx.doi.org/10.1007/s10552-009-9466-0