Korean Journal of Food Science and Technology (한국식품과학회지)

Korean Society of Food Science and Technology (한국식품과학회)
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Screening of anti-obesity drugs, their analogues and prohibited ingredients in slimming foods

식품 중 부정 혼입된 비만치료제 및 사용금지 성분 실태조사

  • Yun, Jisuk (New Hazardous Substance Team, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Choi, Jangduck (New Hazardous Substance Team, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Kwon, Kisung (New Hazardous Substance Team, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Jo, Cheon-Ho (New Hazardous Substance Team, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
  • 윤지숙 (식품의약품안전처 식품의약품안전평가원 신종유해물질팀) ;
  • 최장덕 (식품의약품안전처 식품의약품안전평가원 신종유해물질팀) ;
  • 권기성 (식품의약품안전처 식품의약품안전평가원 신종유해물질팀) ;
  • 조천호 (식품의약품안전처 식품의약품안전평가원 신종유해물질팀)
  • Received : 2016.06.02
  • Accepted : 2016.07.09
  • Published : 2016.10.31
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Abstract

Globally, obesity has been recognized as a serious health problem. Recently, slimming foods for weight loss and maintenance were found to contain anti-obesity drugs, their analogues, and prohibited ingredients. To avoid inspections by the Government, structurally modified analogs have been continuously synthesized. For rapid determination of adulterated slimming products, we simultaneously analyzed 21 illegal compounds using liquid chromatography (LC) equipped with photo diode array, and LC coupled with tandem mass spectrometry. The validation of the method was performed with regard to selectivity, linearity, limit of detection, limit of quantification, precision, and accuracy. We purchased 128 samples from the Korean market and online sources in the year 2015. In 31 samples, 3 illegal compounds were detected as follows: 9.9-135.3 mg/g of sibutramine, 0.2-17.5 mg/g of yohimbine, and 1.8 mg/g of icariin. This simultaneous detection method might prove to be a simple and rapid analysis for monitoring illegal compounds in slimming foods.

비만은 전세계적으로 심각한 문제로 인식되고 있다. 최근 체중감소와 유지를 위한 다이어트제품에 비만치료제와 그 유사물질, 사용금지 성분들이 발견되고 있다. 정부의 감시를 피하기 위하여, 비만치료제의 화학구조를 일부 변형시킨 유사물질이 지속적으로 합성되고 있다. 부정물질이 혼입된 다이어트식품을 신속하게 검사하기 위하여, 국내에서 판매되는 제품과 해외 인터넷 사이트에서 128건의 다이어트제품을 구매하였으며, HPLC-PDA와 LC-MS/MS로 21종의 부정물질을 동시분석하였다. 시험법의 유효성 검증은 선택성, 직선성, 검출한계, 정량한계, 정확성, 정밀성을 검토하였다. 분석결과 31건의 시료에서 부정물질이 검출되었으며, 검출수준은 시부트라민 9.9-135.3 mg/g, 요힘빈 0.2-17.5 mg/g, 이카린 1.8 mg/g이었다. 본 연구의 부정물질 분석법은 간단하면서도 신속한 분석법으로, 식품안전관리를 위한 기초자료로 활용될 수 있을 것으로 사료된다.

Keywords

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