Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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Temporal and subcellular distributions of Cy5.5-labeled hyaluronic acid nanoparticles in mouse organs during 28 days as a drug carrier

  • Lin, Chunmei (College of Chinese Medicinal Materials, Jilin Agricultural University) ;
  • Kim, Saet Byeol (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University) ;
  • Yon, Jung-Min (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University) ;
  • Park, Seul Gi (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University) ;
  • Gwon, Lee Wha (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University) ;
  • Lee, Jong-Geol (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University) ;
  • Baek, In-Jeoung (Asan Institute for Life Sciences, Asan Medical Center and University of Ulsan) ;
  • Lee, Beom Jun (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University) ;
  • Yun, Young Won (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University) ;
  • Nam, Sang-Yoon (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University)
  • Received : 2017.08.24
  • Accepted : 2017.12.21
  • Published : 2017.12.31
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Abstract

Temporal and subcellular distributions of hyaluronic acid (HA) as a degradable nanoparticle (NP) in animals were investigated to determine if HA-NP could be utilized as an appropriate drug delivery system. After mice were intravenously injected with 5 mg/kg of Cy5.5-labeled HA-NP sized 350-400 nm or larger HA-polymers, the fluorescence intensity was measured in all homogenized organs from 0.5 h to 28 days. HA-NP was greatly detected in spleen, liver and kidney until day 28, while it was maintained at low levels in other organs. HA-polymer was observed at low levels in all organs. HA-NP quantities in spleen and liver were reduced until day 3, but increased sharply between days 3 and 7, then decreased again, while their HA-polymers were maintained at low levels until day 28. In kidneys, both HA-NP and HA-polymer showed high levels after 0.5 h of administration, but steadily decreased until day 28. According to ultrastructural analyses, HA-NP was engulfed in Kupffer cells of liver and macrophages of spleen and kidney at day 1 and was accumulated in the cytoplasm of kidney tubular cells at day 7. Overall, these findings suggest that HA-NP could be considered a desirable drug carrier in the liver, kidney, or spleen.

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References

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