한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제34권6호
  • /
  • Pages.404-409
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  • 2017
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
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Hepatoprotective Effect of Blue Honeysuckle on Rat Hypothyroidism

  • Lee, Woo-Yeol (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University) ;
  • Yi, Seong-Joon (Department of Veterinary Anatomy, College of Veterinary Medicine, Kyungpook National University) ;
  • Yun, Sungho (Department of Veterinary Surgery, College of Veterinary Medicine, Kyungpook National University) ;
  • Oh, Tae-Ho (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University) ;
  • Kim, Hong-Tae (Veterinary Service Laboratory, Busan Metropolitan City Institute of Health and Environment) ;
  • Lim, Mee-Kyung (School of Healthcare and Biotechnology, Kyungwoon University) ;
  • Lee, Keun-Woo (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University)
  • 투고 : 2017.09.12
  • 심사 : 2017.12.13
  • 발행 : 2017.12.31
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초록

This study was to determine whether blue honeysuckle lyophilized concentrated powder (BH) has positive effects on hypothyroidism and related liver damage in propylthiouracil-induced Hypothyroidism. Levothyroxine (LT4)-treated group was administrated by intraperitoneal injection with LT4, while BH or Flos Lonicerae lyophilized aqueous extract (LF)-treated groups were orally administrated for 42 days which two weeks pri or to PTU injection. The changes in organ weight, serum AST & ALT, serum lipid level, liver defense system were measured and the histopathology of the liver was observed. The oral administrations of 125, 250, and 500 mg/kg of BH showed favorable effects compared to LF on hypothyroidism-related liver damages through the enhance antioxidant defense system.

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참고문헌

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