Korean Journal of Agricultural Science (농업과학연구)

Institute of Agricultural Science, CNU (충남대학교 농업과학연구소)
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Role of dietary nucleotides to mitigate post-weaning stress in newly weaned pigs

  • Shin, Taeg Kyun (Department of Animal Science and Biotechnology, Chungnam National University) ;
  • Wickramasuriya, Samiru Sudharaka (Department of Animal Science and Biotechnology, Chungnam National University) ;
  • Cho, Hyun Min (Department of Animal Science and Biotechnology, Chungnam National University) ;
  • Kim, Eunjoo (Department of Animal Science and Biotechnology, Chungnam National University) ;
  • Kim, Younghwa (National Institute of Animal Science, RDA) ;
  • Park, Juncheol (National Institute of Animal Science, RDA) ;
  • Macelline, Shemil Priyan (Department of Animal Science and Biotechnology, Chungnam National University) ;
  • Heo, Jung Min (Department of Animal Science and Biotechnology, Chungnam National University) ;
  • Yi, Young-Joo (Division of Biotechnology, Safety, Environment and Life Science Institute, Chonbuk National University)
  • Received : 2017.09.11
  • Accepted : 2017.10.18
  • Published : 2017.12.31
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Abstract

This review provides an overview of dietary nucleotides as an alternative to in-feed antibiotics for weaning pigs. Dietary nucleotides are composed of DNA or RNA molecules and are normally contained in protein-rich feed ingredient, brewer's yeast, yeast extract, and milk. Weaning pigs are suffering from several stresses, such as environmental challenges (i.e. crowding, transportation, and feeding). Such stressors can damage the intestinal epithelium and cause an invasion by Escherichia coli, secondary inflammatory responses, and post weaning diarrhea. To overcome weaning disorder, people often use antibiotics which reduce symptoms and boost growth performance. However, since antibiotics were banned due to concerns of antibiotic resistant bacteria, researchers are studying alternative materials to antibiotics. Dietary nucleotides are one of the alternative materials for replacing antibiotics and can be used in abnormal conditions, such as weaning diarrhea, low digestibility, and disease condition. Nucleotides have substances that have important roles in cell division and cell growth, affecting growth performance, intestinal condition, and immunological effect at the weaning stage. However, nucleotides' composition is very different between sources and this aspect makes it difficult to utilize nucleotides at the weaning stage. Therefore, this review paper focuses on i) the characteristics and functions of dietary nucleotides and ii) the effect of dietary nucleotides on the growth performance and immune system of pigs.

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References

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