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Calcium-activated chloride channels: a new target to control the spiking pattern of neurons

  • Ha, Go Eun (Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University) ;
  • Cheong, Eunji (Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University)
  • Received : 2017.02.28
  • Published : 2017.03.31

Abstract

The nature of encoded information in neural circuits is determined by neuronal firing patterns and frequencies. This paper discusses the molecular identity and cellular mechanisms of spike-frequency adaptation in the central nervous system (CNS). Spike-frequency adaptation in thalamocortical (TC) and CA1 hippocampal neurons is mediated by the $Ca^{2+}$-activated $Cl^-$ channel (CACC) anoctamin-2 (ANO2). Knockdown of ANO2 in these neurons results in increased number of spikes, in conjunction with significantly reduced spike-frequency adaptation. No study has so far demonstrated that CACCs mediate afterhyperpolarization currents, which result in the modulation of neuronal spike patterns in the CNS. Our study therefore proposes a novel role for ANO2 in spike-frequency adaptation and transmission of information in the brain.

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Cited by

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