Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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Dehydroepiandrosterone and cortisol concentrations in the cerebrospinal fluid of dogs

  • Mongillo, Paolo (Department of Comparative Biomedicine and Food Sciences, University of Padova) ;
  • Bernardini, Marco (Department of Animal Medicine, Production and Health, University of Padova) ;
  • Prana, Elisa (Department of Comparative Biomedicine and Food Sciences, University of Padova) ;
  • Balducci, Federica (Portoni Rossi Veterinary Hospital) ;
  • Gabai, Gianfranco (Department of Comparative Biomedicine and Food Sciences, University of Padova) ;
  • Marinelli, Lieta (Department of Comparative Biomedicine and Food Sciences, University of Padova)
  • Received : 2016.11.09
  • Accepted : 2017.01.19
  • Published : 2017.03.31
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Abstract

Concentrations of cortisol, dehydroepiandrosterone and dehydroepiandrosterone-sulfate were measured by performing radioimmunoassay of the cerebrospinal fluid of 68 dogs diagnosed with idiopathic epilepsy or inflammatory, degenerative, or non-neurological disease. No steroid concentration differences were found among diagnoses. Dehydroepiandrosterone and dehydroepiandrosterone-sulfate concentrations were higher in males than in females and dehydroepiandrosterone-sulfate decreased with increasing age. No sex or age effects were observed on cortisol or hormone ratios. Although limited to a relatively small sample, our results show sex- and age-dependent variations in these neurosteroid concentrations in cerebrospinal fluid. The role of such variations in the pathophysiology of the dog brain warrants further investigation.

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