Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Anti-aging effects of casuarictin on UVB-induced CCD-986sk cell

UVB유도성 CCD-986sk cell에서의 Casuarictin의 항노화 효과

  • Kim, You Ah (Bio Materials R&D Center, Kolmar Korea, CBTP, Future Convergent Tech Center) ;
  • Kim, Dong Hee (Traditional Korean Medicine Technology Division, R&D Department, Applied Product Development Team, National Development Institute of Korean Medicine) ;
  • Kim, Young A (Traditional Korean Medicine Technology Division, R&D Department, Applied Product Development Team, National Development Institute of Korean Medicine) ;
  • Yu, Jae Myo (Traditional Korean Medicine Technology Division, R&D Department, Applied Product Development Team, National Development Institute of Korean Medicine) ;
  • Park, Byoung Jun (Bio Materials R&D Center, Kolmar Korea, CBTP, Future Convergent Tech Center) ;
  • Son, Jun Ho (Traditional Korean Medicine Technology Division, R&D Department, Applied Product Development Team, National Development Institute of Korean Medicine)
  • Received : 2016.08.17
  • Accepted : 2016.10.20
  • Published : 2017.03.30
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Abstract

To develop a new functional agent for cosmetics, we investigated the anti-aging activities in fibroblasts of casuarictin. The anti-aging effect of casuarictin in CCD-986sk cell was as follows: it inhibited ROS expression increased by Ultraviolet B and suppressed pro-collagen expression. Also, casuarictin had inhibited Matrix metalloproteinase-1 expression. Therefore, the results suggested that casuarictin has considerable potential as a cosmetics ingredient with a anti-aging effect.

본 연구는 새로운 기능성 화장품 소재 개발을 위해 복분자 씨앗의 구성성분인 casuarictin을 이용하여 섬유아세포내에서의 항노화 효과를 확인 하고자 하였다. Casuarictin의 항노화 효과를 CCD-986sk 세포를 이용하여 측정한 결과, casuarictin은 UVB에 의해 증가된 ROS 발현을 억제하였으며, pro-collagen의 발현을 증가시키고 MMP-1의 발현을 억제하는 것으로 나타났다. 이는 노화 인자인 활성산소종의 생성 억제와 주름과 밀접한 관련이 있는 콜라겐의 합성 및 분해억제를 통해 항산화 및 주름개선 효과가 있는 것으로 판단되며, 따라서 casuarictin은 화장품 분야에서 항노화 소재로서의 활용가치가 있을 것으로 사료된다.

Keywords

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