Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administration

  • Chen, Yin Bin (Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences) ;
  • Wang, Yu Fang (Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences) ;
  • Hou, Wei (Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences) ;
  • Wang, Ying Ping (Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences) ;
  • Xiao, Sheng Yuan (Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences) ;
  • Fu, Yang Yang (School of Life Science of Beijing Institute of Technology) ;
  • Wang, Jia (Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences) ;
  • Zheng, Si Wen (Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences) ;
  • Zheng, Pei He (Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences)
  • Received : 2015.11.18
  • Accepted : 2016.03.24
  • Published : 2017.04.15
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Abstract

Background: Both ginsenoside Re and B-complex vitamins are widely used as nutritional supplements. They are often taken together so as to fully utilize their antifatigue and refreshing effects, respectively. Whether actually a drug-nutrient interaction exists between ginsenoside Re and B-complex vitamins is still unknown. The objective of this study was to simultaneously investigate the effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after their oral administration. The study results will provide valuable theoretical guidance for the combined utilization of ginseng and B-complex vitamins. Methods: Ginsenoside Re with or without B-complex vitamins was orally administered to mice to evaluate its antifatigue effects and to rats to evaluate its bioavailability. The antifatigue activity was evaluated by the weight-loaded swimming test and biochemical parameters, including hepatic glycogen, plasma urea nitrogen, and blood lactic acid. The concentration of ginsenoside Re in plasma was determined by liquid chromatography-tandem mass spectrometry. Results: No antifatigue effect of ginsenoside Re was noted when ginsenoside Re in combination with B-complex vitamins was orally administered to mice. B-complex vitamins caused to a reduction in the bioavailability of ginsenoside Re with the area under the concentration-time curve from zero to infinity markedly decreasing from $11,830.85{\pm}2,366.47h{\cdot}ng/mL$ to $890.55{\pm}372.94h{\cdot}ng/mL$. Conclusion: The results suggested that there were pharmacokinetic and pharmacodynamic drug-nutrient interactions between ginsenoside Re and B-complex vitamins. B-complex vitamins can significantly weaken the antifatigue effect and decrease the bioavailability of ginsenoside Re when simultaneously administered orally.

Keywords

References

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