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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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microRNA-200a-3p enhances mitochondrial elongation by targeting mitochondrial fission factor

  • Lee, Heejin (Department of Biochemistry, College of Medicine, The Catholic University of Korea) ;
  • Tak, Hyosun (Department of Biochemistry, College of Medicine, The Catholic University of Korea) ;
  • Park, So Jung (Department of Gerontology, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Jo, Yoon Kyung (Department of Gerontology, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Cho, Dong Hyung (Department of Gerontology, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Lee, Eun Kyung (Department of Biochemistry, College of Medicine, The Catholic University of Korea)
  • Received : 2017.01.14
  • Accepted : 2017.01.31
  • Published : 2017.04.30
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Abstract

Mitochondria play pivotal roles in the ATP production, apoptosis and generation of reactive oxygen species. Although dynamic regulation of mitochondria morphology is a critical step to maintain cellular homeostasis, the regulatory mechanisms are not yet fully elucidated. In this study, we identified miR-200a-3p as a novel regulator of mitochondrial dynamics by targeting mitochondrial fission factor (MFF). We demonstrated that the ectopic expression of miR-200a-3p enhanced mitochondrial elongation, mitochondrial ATP synthesis, mitochondrial membrane potential and oxygen consumption rate. These results indicate that miR-200a-3p positively regulates mitochondrial elongation by downregulating MFF expression.

Keywords

References

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