Journal of Gastric Cancer

The Korean Gastric Cancer Association (대한위암학회)
권호 표지
DOI QR코드

DOI QR Code

Gastric Adenocarcinoma Secondary to Primary Gastric Diffuse Large B-cell Lymphoma

  • Sakr, Riwa (Department of Hematology-Oncology, Centre Hospitalier Universitaire Notre Dame des Secours) ;
  • Massoud, Marcel Antoine (Department of Hematology-Oncology, Centre Hospitalier Universitaire Notre Dame des Secours) ;
  • Aftimos, Georges (Department of Pathology, Centre Hospitalier Universitaire Notre Dame des Secours) ;
  • Chahine, Georges (Department of Hematology-Oncology, Hotel Dieu de France Hospital, Universite Saint-Joseph de Beyrouth)
  • Received : 2016.07.07
  • Accepted : 2016.12.11
  • Published : 2017.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Despite the decreasing incidence and mortality from gastric cancer, it remains a major health problem worldwide. Ninety percent of cases are adenocarcinomas. Here, we report a case of gastric adenocarcinoma developed after successful treatment of prior primary gastric diffuse large B-cell lymphoma (DLBCL). Our patient was an elderly man with primary gastric DLBCL in whom complete remission was achieved after R-CHOP (cyclophosphamide, adriamycin, vincristine, prednisolone plus rituximab) chemotherapy. Helicobacter pylori infection persisted despite adequate treatment leading to sustained chronic gastritis. The mean time to diagnose metachronous gastric carcinoma was seven years. We believe that a combination of many risk factors, of which chronic H. pylori infection the most important, led to the development of gastric carcinoma following primary gastric lymphoma. In summary, patients who have been successfully treated for primary gastric lymphoma should be followed up at regular short intervals. H. pylori infection should be diagnosed promptly and treated aggressively.

Keywords

References

  1. Coleman CN, Williams CJ, Flint A, Glatstein EJ, Rosenberg SA, Kaplan HS. Hematologic neoplasia in patients treated for Hodgkin's disease. N Engl J Med 1977;297:1249-1252. https://doi.org/10.1056/NEJM197712082972303
  2. Ioannidis O, Sekouli A, Paraskevas G, Papadimitriou N, Konstantara A, Kotronis A, et al. Metachronous early gastric adenocarcinoma presenting coinstantaneously with complete remission of stage IV gastric MALT lymphoma. Arab J Gastroenterol 2013;14:20-23. https://doi.org/10.1016/j.ajg.2013.01.004
  3. Nakamura S, Aoyagi K, Iwanaga S, Yao T, Tsuneyoshi M, Fujishima M. Synchronous and metachronous primary gastric lymphoma and adenocarcinoma: a clinicopathological study of 12 patients. Cancer 1997;79:1077-1085. https://doi.org/10.1002/(SICI)1097-0142(19970315)79:6<1077::AID-CNCR4>3.0.CO;2-D
  4. Hamaloglu E, Topaloglu S, Ozdemir A, Ozenc A. Synchronous and metachronous occurrence of gastric adenocarcinoma and gastric lymphoma: a review of the literature. World J Gastroenterol 2006;12:3564-3574. https://doi.org/10.3748/wjg.v12.i22.3564
  5. Inaba K, Kushima R, Murakami N, Kuroda Y, Harada K, Kitaguchi M, et al. Increased risk of gastric adenocarcinoma after treatment of primary gastric diffuse large B-cell lymphoma. BMC Cancer 2013;13:499. https://doi.org/10.1186/1471-2407-13-499
  6. Copie-Bergman C, Locher C, Levy M, Chaumette MT, Haioun C, Delfau-Larue MH, et al. Metachronous gastric MALT lymphoma and early gastric cancer: is residual lymphoma a risk factor for the development of gastric carcinoma? Ann Oncol 2005;16:1232-1236. https://doi.org/10.1093/annonc/mdi242
  7. Leung WK, Lin SR, Ching JY, To KF, Ng EK, Chan FK, et al. Factors predicting progression of gastric intestinal metaplasia: results of a randomised trial on Helicobacter pylori eradication. Gut 2004;53:1244-1249. https://doi.org/10.1136/gut.2003.034629
  8. Chow WH, Blaser MJ, Blot WJ, Gammon MD, Vaughan TL, Risch HA, et al. An inverse relation between cagA+ strains of Helicobacter pylori infection and risk of esophageal and gastric cardia adenocarcinoma. Cancer Res 1998;58:588-590.
  9. Zorlu AF, Atahan IL, Gedikoglu G, Ruacan S, Sayek I, Tekuzman G. Does gastric adenocarcinoma develop after the treatment of gastric lymphoma? J Surg Oncol 1993;54:126-131. https://doi.org/10.1002/jso.2930540214
  10. Pointner R, Schwab G, Konigsrainer A, Bodner E, Schmid KW. Gastric stump cancer: etiopathological and clinical aspects. Endoscopy 1989;21:115-119. https://doi.org/10.1055/s-2007-1012917
  11. Vardiman JW, Harris NL, Brunning RD. The World Health Organization (WHO) classification of the myeloid neoplasms. Blood 2002;100:2292-2302. https://doi.org/10.1182/blood-2002-04-1199
  12. Neglia JP, Friedman DL, Yasui Y, Mertens AC, Hammond S, Stovall M, et al. Second malignant neoplasms in five-year survivors of childhood cancer: childhood cancer survivor study. J Natl Cancer Inst 2001;93:618-629. https://doi.org/10.1093/jnci/93.8.618
  13. Al-Akwaa AM, Siddiqui N, Al-Mofleh IA. Primary gastric lymphoma. World J Gastroenterol 2004;10:5-11. https://doi.org/10.3748/wjg.v10.i1.5
  14. Haruma K, Suzuki T, Tsuda T, Yoshihara M, Sumii K, Kajiyama G. Evaluation of tumor growth rate in patients with early gastric carcinoma of the elevated type. Gastrointest Radiol 1991;16:289-292. https://doi.org/10.1007/BF01887370

Cited by

  1. Antineoplastics : Various toxicities: case report vol.1668, pp.1, 2017, https://doi.org/10.1007/s40278-017-35516-z