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Protective Effects of Loquat (Eriobotrya japonica Lindl.) Leaf Extract on Ethanol-Induced Liver Damage in Rats

비파 잎 추출물이 에탄올을 투여한 흰쥐의 간 손상 지표의 개선효과

  • Lee, Hwan (Dept. of Food and Nutrition, Chosun University) ;
  • Park, Yeon Jin (Dept. of Hotel Cusine & Baking, Jeonnam Provincial College) ;
  • Lee, Jae-Joon (Dept. of Food and Nutrition, Chosun University)
  • 이환 (조선대학교 식품영양학과) ;
  • 박연진 (전남도립대학교 호텔조리제빵과) ;
  • 이재준 (조선대학교 식품영양학과)
  • Received : 2017.11.09
  • Accepted : 2017.11.17
  • Published : 2017.11.30

Abstract

This study was performed to determine the hepatoprotective effects of ethanol extract of loquat leaf (LL) on alcohol-induced liver damage in rats. Sprague-Dawley rats (n=32) were divided into the following four groups: normal group (NOR), ethanol administrated group (ET), ethanol plus LL 200 mg/kg BW/day administrated group (ET-LLL), and ethanol plus LL 400 mg/kg Bw/day administrated group (ET-LLH). Body weight gain and food intake of the ET group were significantly reduced compared to those of the ET-LLL and ET-LLH groups. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) activities elevated by ethanol administration were significantly reduced by LL administration. Serum triglyceride (TG) and total cholesterol (TC) contents and hepatic TG and TC contents of the ET group were significantly elevated compared to those of the NOR group. However, TG and TC contents in the serum and liver were significantly reduced in the ET-LLH group. Hepatic glutathione (GSH) contents of the ET-LLL and ET-LLH groups were significantly elevated, and hepatic thiobarbituric acid reactive substances (TBARS) contents were reduced compared to that of the ET group. Taken together, these results suggest that LL may have a possible protective effect on the improvement of hepatic injury by ethanol administration.

Keywords

Acknowledgement

Supported by : Chosun University

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