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A Simple, Efficient, Catalyst-Free and Solvent-Less Microwave-Assisted Process for N-Cbz Protection of Several Amines

  • Aouf, Zineb (Laboratory of Applied Organic Chemistry, Bioorganic Chemistry Group, Department of Chemistry, Sciences Faculty, - Badji Mokhtar - Annaba University) ;
  • Mansouri, Rachida (Laboratory of Applied Organic Chemistry, Bioorganic Chemistry Group, Department of Chemistry, Sciences Faculty, - Badji Mokhtar - Annaba University) ;
  • Lakrout, Salah (Laboratory of Applied Organic Chemistry, Bioorganic Chemistry Group, Department of Chemistry, Sciences Faculty, - Badji Mokhtar - Annaba University) ;
  • Berredjem, Malika (Laboratory of Applied Organic Chemistry, Bioorganic Chemistry Group, Department of Chemistry, Sciences Faculty, - Badji Mokhtar - Annaba University) ;
  • Aouf, Nour-Eddine (Laboratory of Applied Organic Chemistry, Bioorganic Chemistry Group, Department of Chemistry, Sciences Faculty, - Badji Mokhtar - Annaba University)
  • Received : 2017.03.28
  • Accepted : 2017.06.15
  • Published : 2017.08.20

Abstract

A simple, green and chemo-selective method for the N-benzyloxycarbonylation of amines, ${\beta}$-amino alcohols, ${\alpha}$-amino esters and sulfonamides has been developed under microwave irradiation. Good to excellent yields of the N-benzyloxycarbamates compounds were obtained in short times without any side products.

Keywords

References

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