The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Skin elasticity improvement effect of Young persimmon and Heated young persimmon by decreased Advanced glycation end products(AGEs)

떫은감과 포제 떫은감의 최종당화산물 생성 억제를 통한 피부 탄력 개선 효과

  • Kim, Soo Hyun (College of Korean Medicine, Daegu Haany University) ;
  • Lee, AhReum (College of Korean Medicine, Daegu Haany University) ;
  • Kim, SuJi (College of Korean Medicine, Daegu Haany University) ;
  • Kim, Kyeong Jo (College of Korean Medicine, Daegu Haany University) ;
  • Kwon, Ojun (Gyeongbuk Institute for Regional Program Evaluation) ;
  • Choi, Joon Young (Sae Earl Bio Food co., Ltd) ;
  • Koo, Jin Suk (Dept. of Bioresource Science, Andong National University) ;
  • Roh, Seong-Soo (College of Korean Medicine, Daegu Haany University)
  • 김수현 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 이아름 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 김수지 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 김경조 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 권오준 (경북지역사업평가단) ;
  • 최준영 (농업회사법인 새얼 바이오푸드 주식회사) ;
  • 구진숙 (안동대학교 자연과학대학 생약자원학과) ;
  • 노성수 (대구한의대학교 한의과대학 본초약리학교실)
  • Received : 2017.06.11
  • Accepted : 2017.07.15
  • Published : 2017.07.30
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Abstract

Objectives : Advanced glycation end products (AGEs) is bind formation of glucose and protein. Acceleration of AGE formation during hyperglycemia is associated with the pathogenesis of diabetic complications and causes kidney and skin damage. The aim of this study was investigated the AGEs inhibitory activity and antioxidant activity of water extracts from young persimmon (YP) and heated young persimmon (HYP). Methods : Paeoniae Radix Alba (YP) is prepared by heating with 30% ethanol. AGEs formation inhibitory activities of YP and HYP measured using bovine serum albumin. To evaluate the protective effects of YP and HYP in diabetic rats induced with streptozotocin (STZ) and methyl glyoxal (MGO), SD rats were distributed into four groups; normal mice (Nor), AGEs-induced rats (Con), AGEs-induced rats treated with 100 mg/kg YP (YP), AGEs-induced rats treated with 100 mg/kg heated YP (HYP) for 3weeks. Heated young persimmon respectively decrease AGEs construction. Results : YP and HYP administration inhibited the biomarkers of AGEs in serum, kidney and skin tissues. AGE-induced rats revealed that the significant decreased collagen however, heat processing methods of young persimmon up regulated inhibits AGEs-induced collagen decrease. The expressions of AGEs were decreased in YP and HYP treated group compared with the control group in tissues. It specifies that HYP has potential to serve as a positive regulator of via AGEs path way. Conclusion : It has proposed that may have an improvement effect on diabetic complications, heated young persimmon has AGEs inhibitory excellent activities and antioxidant effect.

Keywords

References

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