The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Skin Wrinkle Improvement Effect of Paeoniae radix and processed Paeoniae radix Through inhibition of Advanced glycation end products (AGEs)

작약 및 포제작약의 최종당화산물 억제를 통한 피부 주름 개선 효과

  • Kim, SuJi (College of Korean Medicine, Daegu Haany University) ;
  • Lee, AhReum (College of Korean Medicine, Daegu Haany University) ;
  • Kim, SooHyun (College of Korean Medicine, Daegu Haany University) ;
  • Kim, KyeongJo (College of Korean Medicine, Daegu Haany University) ;
  • Kwon, OJun (Gyeongbuk Institute for Regional Program Evaluation) ;
  • Choi, JoonYoung (Sae Earl Bio Food co., Ltd) ;
  • Koo, JinSuk (Dept. of Bioresource Sciences, Andong National Univ.) ;
  • Roh, Seong-Soo (College of Korean Medicine, Daegu Haany University)
  • 김수지 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 이아름 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 김수현 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 김경조 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 권오준 (경북지역산업평가단) ;
  • 최준영 (농업회사법인 새얼 바이오푸드 주식회사) ;
  • 구진숙 (안동대학교 자연과학대학 생약자원학과) ;
  • 노성수 (대구한의대학교 한의과대학 본초약리학교실)
  • Received : 2017.06.12
  • Accepted : 2017.07.15
  • Published : 2017.07.30
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Abstract

Objectives : Collagen decrease of Skin appears through various path ways. One of causes may be the Advanced glycation endproducts (AGEs) that combine formation of glucose and protein. The aim of this study was to explore the prevent wrinkle formation of Paeoniae radix (PR) and heated Paeoniae radix (HPR) via AGEs path way. Methods : AGEs formation inhibitory activities of PR and HPR measured using bovine serum albumin, glucose, and fructose. To evaluate the protective effects of PR and HPR in diabetic rats induced with streptozotocin (STZ) and methyl glyoxal (MGO), SD rat were distributed into four groups. Normal rats (Nor), AGEs-induced rats (Con), AGEs-induced rats treated with 100 mg/kg PR(PR), AGEs-induced rats treated with 100 mg/kg HPR (HPR). To induce AGEs, streptozotocin (50 mg/kg) was administered intraperitoneally and after 3 days administrated 100mM methyl glyoxal for 3 weeks. Results : The oral administration of HPR inhibited AGEs in skin tissues compared with PR. The increased reactive oxygen species (ROS) levels in the serum were diminished by HPR treatment. The analyses of kidney and skin tissues proteins indicated that HPR treatment effectively reduced AGEs related protein levels as compared to that by PR treatment. Also, HPR decreased anti-oxidant related protein levels in skin tissues such as catalase, glutathione peroxidase. Moreover, it inhibited the reduction of COL1A2 by decreasing MMP-1. Conclusion : Based on these results, it was suggested that PR and HPR could have Improving effects on wrinkle formation. These evidences provide useful information for the development wrinkle formation treated agent.

Keywords

References

  1. Kim ID. Effect of paeoniflorin on the anti-inflammatory and anti-oxidation. Silla University. 2009.
  2. Park HR, Jung UH, Jeong LY, Yee ST, Jo SK. Inhibition of Tumor Growth through Macrophage Activation by Polysaccharide Fraction from Peonia japonica. Journal of the Korean Society of Food Science and Nutrition. 2003 ; 32 : 149-54. https://doi.org/10.3746/jkfn.2003.32.1.149
  3. Park HR, Ham YH, Yee ST, Paik SG. Characteristics of B cell proliferation by polysaccharide fraction of Paeonia japonica miyabe. Immune Network. 2001 ; 1 : 126-34. https://doi.org/10.4110/in.2001.1.2.126
  4. Yoon CH. Comparative study of anti-inflammatory effects of Paeoniae Radix prepared by different processing methods. Wonkwang University. 2003.
  5. Jung MG, An YN, Kang GH, Jo YS, Kim JH. Comparison on the Extract Content by Different Processing Method in Peony (Paeonia lactiflora Pall.) Root. Korean J. Medicinal Crop Sci. 2003 ; 11 : 201-206.
  6. He Y1, Zhao HD, He BX, Tang LY, Zhang QW, Wang ZJ. Experimental study on processing of Paeonia lactiflora. Zhongguo Zhong Yao Za Zhi. 2006 ; 31 : 889-91.
  7. Kwon HO, Lee MH, Kim YJ, Kim E, Kim OK. Beneficial effects of Acanthopanax seticosus extract in type II diabetes animal model via down-regulation of advanced glycated hemoglobin and glycosylation end products. J. Korean Soc Food Sci Nutr. 2016 ; 45 : 929-37. https://doi.org/10.3746/jkfn.2016.45.7.929
  8. Huebschmann AG, Regensteiner JG, Vlassara H, Reusch JEB. Diabetes and advanced glycoxidation end products. Diabetes Care. 2006 ; 29 : 1420-32. https://doi.org/10.2337/dc05-2096
  9. Lee HS, Yoon JA. Inhibitory activity of advanced glycation endproducts (AGE) formation of edible plant for development of anti-wrinkle ingredients. J. Korean Soc Food Sci Nutr. 2010 ; 39 : 186-92. https://doi.org/10.3746/jkfn.2010.39.2.186
  10. Rahbar S, Figarola JL. Novel inhibitors of advanced glycation endproducts. Arch Biochem Biophys. 2003 ; 419 : 63-79. https://doi.org/10.1016/j.abb.2003.08.009
  11. Eika B, Levin RM, Longhurst PA. Collagen and bladder function in streptozotocin-diabetic rats : effects of insulin and aminoguanidine. J Urol. 1992 ; 148 : 167-172. https://doi.org/10.1016/S0022-5347(17)36546-1
  12. Kelly DJ, Gilbert RE, Cox AJ, Soulis T, Jerums G, Cooper ME. Aminoguanidine ameliorates overexpression of prosclerotic growth factors and collagen deposition in experimental diabetic nephropathy. J Am Soc Nephrol. 2001 ; 12 : 2098-2107.
  13. Klandorf H, Zhou Q, Sams AR. Inhibition by aminoguanidine of glucose-derived collagen crosslinking in skeletal muscle of broiler breeder hens. Poult Sci. 1996 ; 75 : 432-437. https://doi.org/10.3382/ps.0750432
  14. Kochakian M, Manjula BN, Egan JJ. Chronic dosing with aminoguanidine and novel advanced glycosylation end product-formation inhibitors ameliorates crosslinking of tail tendon collagen in STZ-induced diabetic rats. Diabetes. 1996 ; 45 : 1694-1700. https://doi.org/10.2337/diab.45.12.1694
  15. Kim SA, Lee JA, Kim MJ, Kim AH, Kim YA, Yun HJ, Cho YH. Effect of Ascorbic Acid, Silicon, Fe, Proline and Lysine on Proliferation and Collagen Synthesis in the Human Dermal Fibroblast Cell (HS27). J Korean Soc Food Sci Nutr. 2009 ; 38 : 1492-1498. https://doi.org/10.3746/jkfn.2009.38.11.1492
  16. Radi R, Beckman JS, Bush KM, Freeman BA. Peroxynitrite-induced membrane lipid peroxidation : the cytotoxic potential of superoxide and nitric oxide. Arch Biochem Biophys. 1991 ; 288 : 481-487. https://doi.org/10.1016/0003-9861(91)90224-7
  17. Kim NM, Koo BS, Lee SK, Hwang EI, So SH, Do JH. Effect of Korean red ginseng on collagen biosynthesis and MMP-1 activity in human dermal fibroblast. J Ginseng Res. 2007 ; 31 : 86-92. https://doi.org/10.5142/JGR.2007.31.2.086
  18. Kim JH, Kim CK ,Kim JS. Inhibitory Effects of the EtOH Extract of Aster koraiensis on AGEs formation in STZ-induced diabetic rats and AGEs-induced Protein Cross-linking in vitro. Kor. J. Pharmacogn. 2016 ; 47 : 312-318.
  19. Kim CK, Jang DS, Kim JH, Lee GY, Lee YM, Kim YS, Kim JS. Inhibitory Effects of the Seeds of Cornus officinalis on AGEs Formation and AGEs-induced Protein Cross-Linking. Kor. J. Pharmacogn. 2008 ; 39 : 249-254.
  20. Kim YS, Lee YM, Kim CS, Sohn EJ, Jang DS, Kim JS. Inhibitory Effect of KIOM-79, a New Herbal Prescription, on AGEs Formation and Expressions of Type 4 Collagen and TGF-${\beta}1$ in STZ-induced Diabetic Rats. Kor. J. Pharmacogn. 2006 ; 37 : 103-109.
  21. Sell DR, Kleinman NR, Monnier VM. Longitudinal determination of skin collagen glycation and glycoxidation rates predicts early death in C57BL/6NNIA mice. FASEB J. 2000 ; 14 : 145-156. https://doi.org/10.1096/fasebj.14.1.145
  22. Genuth S, Sun W, Cleary P, Sell DR, Dahms W, Malone J, Sivitz W, Monnier VM. Glycation and carboxymethyllysine levels in skin collagen predict the risk of future 10-year progression of diabetic retinopathy and nephropathy in the diabetes control and complications trial and epidemiology of diabetes interventions and complications participants with type 1 diabetes. Diabetes. 2005 ; 54 : 3103-3311. https://doi.org/10.2337/diabetes.54.11.3103
  23. Hwang JY, Lee HS, Han JS. Protective effect of Sasa borealis leaf extract on AAPH-induced oxidative stress in LLC-PK1 cells. J Food Sci Nutr. 2011 ; 16 : 12-17.
  24. Lee JS, Yang R, Shin BD. Effect of Reactive Oxygen Species on the Formation of $N_{\varepsilon}$-(carboxymethyl) lysine, an Endproduct of Maillard Reaction of Proteins. J Korean Soc Food Sci Nutr. 2004 ; 33 : 123-131. https://doi.org/10.3746/jkfn.2004.33.1.123
  25. Kislinger T, Fu C, Huber B, Qu W, Taguchi A, Du Yan S, Hofmann M, Yan SF, Pischetsrieder M, Stern D, Schmidt AM. N(epsilon)-(carboxymethyl) lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression. J. Biol. Chem. 1999 ; 274 : 31740-31749. https://doi.org/10.1074/jbc.274.44.31740
  26. Tanji N, Markowitz GS, Fu C, Kislinger T, Taguchi A, Pischetsrieder M, Stern D, Schmidt AM, D'Agati VD. Expression of advanced glycation end products and their cellular receptor RAGE in diabetic nephropathy and nondiabetic renal disease.J Am Soc Nephrol. 2000 ; 11 : 1656-1666.