References
- Mizushima N, Levine B, Cuervo AM and Klionsky DJ (2008) Autophagy fights disease through cellular selfdigestion. Nature 451, 1069-1075 https://doi.org/10.1038/nature06639
- Kotoulas OB, Kalamidas SA and Kondomerkos DJ (2006) Glycogen autophagy in glucose homeostasis. Pathol Res Pract 202, 631-638 https://doi.org/10.1016/j.prp.2006.04.001
- Singh R, Kaushik S, Wang Y et al (2009) Autophagy regulates lipid metabolism. Nature 458, 1131-1135 https://doi.org/10.1038/nature07976
- Rubinsztein DC, Marino G and Kroemer G (2011) Autophagy and aging. Cell 146, 682-695 https://doi.org/10.1016/j.cell.2011.07.030
- Toth ML, Sigmond T, Borsos E et al (2008) Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans. Autophagy 4, 330-338 https://doi.org/10.4161/auto.5618
- Simonsen A, Cumming RC, Brech A, Isakson P, Schubert DR and Finley KD (2008) Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy 4, 176-184 https://doi.org/10.4161/auto.5269
- Meng Q and Cai D (2011) Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway. J Biol Chem 286, 32324-32332 https://doi.org/10.1074/jbc.M111.254417
- Yang L, Li P, Fu S, Calay ES and Hotamisligil GS (2010) Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab 11, 467-478 https://doi.org/10.1016/j.cmet.2010.04.005
- Jung HS and Lee M-S (2010) Role of autophagy in diabetes and mitochondria. Ann N Y Acad Sci 1201, 79-83 https://doi.org/10.1111/j.1749-6632.2010.05614.x
- Komatsu M, Waguri S, Chiba T et al (2006) Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441, 880-884 https://doi.org/10.1038/nature04723
- Spilman P, Podlutskaya N, Hart MJ et al (2010) Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One 5, e9979 https://doi.org/10.1371/journal.pone.0009979
- Rodriguez-Navarro JA, Rodriguez L, Casarejos MJ et al (2010) Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation. Neurobiol Dis 39, 423-438 https://doi.org/10.1016/j.nbd.2010.05.014
- Pan T, Kondo S, Le W and Jankovic J (2008) The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease. Brain 131, 1969-1978 https://doi.org/10.1093/brain/awm318
- Ravikumar B, Vacher C, Berger Z et al (2004) Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet 36, 585-595 https://doi.org/10.1038/ng1362
- Hara T, Nakamura K, Matsui M et al (2006) Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441, 885-889 https://doi.org/10.1038/nature04724
- Hernandez D, Torres CA, Setlik W et al (2012) Regulation of presynaptic neurotransmission by macroautophagy. Neuron 74, 277-284 https://doi.org/10.1016/j.neuron.2012.02.020
- Komatsu M, Wang QJ, Holstein GR et al (2007) Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci U S A 104, 14489-14494 https://doi.org/10.1073/pnas.0701311104
- Nixon RA (2013) The role of autophagy in neurodegenerative disease. Nat Med 19, 983-997 https://doi.org/10.1038/nm.3232
- Hamasaki M, Furuta N, Matsuda A et al (2013) Autophagosomes form at ER- mitochondria contact sites. Nature 495, 389-393 https://doi.org/10.1038/nature11910
- Ge L, Zhang M and Schekman R (2014) Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment. Elife 3, e04135
- Moreau K, Ravikumar B, Renna M, Puri C and Rubinsztein DC (2011) Autophagosome precursor maturation requires homotypic fusion. Cell 146, 303-317 https://doi.org/10.1016/j.cell.2011.06.023
- Pozueta J, Lefort R, Ribe EM, Troy CM, Arancio O and Shelanski M (2013) Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice. Nat Commun 4, 1939 https://doi.org/10.1038/ncomms2927
- Ohashi Y and Munro S (2010) Membrane delivery to the yeast autophagosome from the Golgi-endosomal system. Mol Biol Cell 21, 3998-4008 https://doi.org/10.1091/mbc.E10-05-0457
- Shpilka T, Welter E, Borovsky N et al (2015) Lipid droplets and their component triglycerides and steryl esters regulate autophagosome biogenesis. EMBO J 34, 2117-2131 https://doi.org/10.15252/embj.201490315
- Rubinsztein DC, Shpilka T and Elazar Z (2012) Mechanisms of autophagosome biogenesis. Curr Biol 22, R29-34 https://doi.org/10.1016/j.cub.2011.11.034
- Ohsumi Y (2014) Historical landmarks of autophagy research. Cell Res 24, 9-23 https://doi.org/10.1038/cr.2013.169
- Pankiv S, Clausen TH, Lamark T et al (2007) p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 282, 24131-24145 https://doi.org/10.1074/jbc.M702824200
- Thurston TLM, Ryzhakov G, Bloor S, von Muhlinen N and Randow F (2009) The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitincoated bacteria. Nat Immunol 10, 1215-1221 https://doi.org/10.1038/ni.1800
- Rabinowitz JD and White E (2010) Autophagy and metabolism. Science 330, 1344-1348 https://doi.org/10.1126/science.1193497
- Geisler S, Holmstrom KM, Skujat D et al (2010) PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol 12, 119-131 https://doi.org/10.1038/ncb2012
- Kim PK, Hailey DW, Mullen RT and Lippincott-Schwartz J (2008) Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes. Proc Natl Acad Sci U S A 105, 20567-20574 https://doi.org/10.1073/pnas.0810611105
- Bernales S, Schuck S and Walter P (2007) ER-phagy: selective autophagy of the endoplasmic reticulum. Autophagy 3, 285-287 https://doi.org/10.4161/auto.3930
- Kirkin V, Lamark T, Sou Y-S et al (2009) A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell 33, 505-516 https://doi.org/10.1016/j.molcel.2009.01.020
- Giacomelli C, Daniele S and Martini C (2017) Potential biomarkers and novel pharmacological targets in protein aggregation-related neurodegenerative diseases. Biochem Pharmacol 131, 1-15 https://doi.org/10.1016/j.bcp.2017.01.017
- Berger Z, Ravikumar B, Menzies FM et al (2006) Rapamycin alleviates toxicity of different aggregateprone proteins. Hum Mol Genet 15, 433-442 https://doi.org/10.1093/hmg/ddi458
- Spencer B, Potkar R, Trejo M et al (2009) Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases. J Neurosci 29, 13578-13588 https://doi.org/10.1523/JNEUROSCI.4390-09.2009
- De Strooper B and Karran E (2016) The Cellular Phase of Alzheimer's Disease. Cell 164, 603-615 https://doi.org/10.1016/j.cell.2015.12.056
- Zare-Shahabadi A, Masliah E, Johnson GVW and Rezaei N (2015) Autophagy in Alzheimer's disease. Rev Neurosci 26, 385-395
- Iqbal K, Liu F and Gong C-X (2016) Tau and neurodegenerative disease: the story so far. Nat Rev Neurol 12, 15-27 https://doi.org/10.1038/nrneurol.2015.225
- Lin L-F, Liao M-J, Xue X-Y et al (2013) Combination of Abeta clearance and neurotrophic factors as a potential treatment for Alzheimer's disease. Neurosci Bull 29, 111-120 https://doi.org/10.1007/s12264-012-1287-6
- Boland B, Kumar A, Lee S et al (2008) Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. J Neurosci 28, 6926-6937 https://doi.org/10.1523/JNEUROSCI.0800-08.2008
- Nilsson P, Loganathan K, Sekiguchi M et al (2013) Abeta secretion and plaque formation depend on autophagy. Cell Rep 5, 61-69 https://doi.org/10.1016/j.celrep.2013.08.042
- Xue Z, Guo Y, Zhang S et al (2014) Beta-asarone attenuates amyloid beta-induced autophagy via Akt/mTOR pathway in PC12 cells. Eur J Pharmacol 741, 195-204 https://doi.org/10.1016/j.ejphar.2014.08.006
- Wolfe DM, Lee J-H, Kumar A, Lee S, Orenstein SJ and Nixon RA (2013) Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification. Eur J Neurosci 37, 1949-1961 https://doi.org/10.1111/ejn.12169
- Tan C-C, Yu J-T, Tan M-S, Jiang T, Zhu X-C and Tan L (2014) Autophagy in aging and neurodegenerative diseases: implications for pathogenesis and therapy. Neurobiol Aging 35, 941-957 https://doi.org/10.1016/j.neurobiolaging.2013.11.019
- Jaber N and Zong W-X (2013) Class III PI3K Vps34: essential roles in autophagy, endocytosis, and heart and liver function. Ann N Y Acad Sci 1280, 48-51 https://doi.org/10.1111/nyas.12026
- Martinez-Vicente M (2015) Autophagy in neurodegenerative diseases: From pathogenic dysfunction to therapeutic modulation. Semin Cell Dev Biol 40, 15-26
- Eketjall S, Janson J, Jeppsson F et al (2013) AZ-4217: a high potency BACE inhibitor displaying acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice. J Neurosci 33, 10075-10084 https://doi.org/10.1523/JNEUROSCI.1165-13.2013
- Marwarha G, Raza S, Meiers C and Ghribi O (2014) Leptin attenuates BACE1 expression and amyloid-beta genesis via the activation of SIRT1 signaling pathway. Biochim Biophys Acta 1842, 1587-1595 https://doi.org/10.1016/j.bbadis.2014.05.015
- Murakami K, Watanabe T, Koike T, Kamata M, Igari T and Kondo S (2016) Pharmacological properties of a novel and potent gamma-secretase modulator as a therapeutic option for the treatment of Alzheimer's disease. Brain Res 1633, 73-86 https://doi.org/10.1016/j.brainres.2015.12.016
- Geldenhuys WJ and Darvesh AS (2015) Pharmacotherapy of Alzheimer's disease: current and future trends. Expert Rev Neurother 15, 3-5 https://doi.org/10.1586/14737175.2015.990884
- Gauthier S and Molinuevo JL (2013) Benefits of combined cholinesterase inhibitor and memantine treatment in moderate-severe Alzheimer's disease. Alzheimers Dement 9, 326-331 https://doi.org/10.1016/j.jalz.2011.11.005
- Ismaili L, Refouvelet B, Benchekroun M et al (2017) Multitarget compounds bearing tacrine- and donepezillike structural and functional motifs for the potential treatment of Alzheimer's disease. Prog Neurobiol 151, 4-34 https://doi.org/10.1016/j.pneurobio.2015.12.003
- Li L, Zhang S, Zhang X et al (2013) Autophagy enhancer carbamazepine alleviates memory deficits and cerebral amyloid-beta pathology in a mouse model of Alzheimer's disease. Curr Alzheimer Res 10, 433-441 https://doi.org/10.2174/1567205011310040008
- Majumder S, Richardson A, Strong R and Oddo S (2011) Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits. PLoS One 6, e25416 https://doi.org/10.1371/journal.pone.0025416
- Zhang X, Heng X, Li T et al (2011) Long-term treatment with lithium alleviates memory deficits and reduces amyloid-beta production in an aged Alzheimer's disease transgenic mouse model. J Alzheimers Dis 24, 739-749 https://doi.org/10.3233/JAD-2011-101875
- Steele JW, Lachenmayer ML, Ju S et al (2013) Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Mol Psychiatry 18, 889-897 https://doi.org/10.1038/mp.2012.106
- Schaeffer V, Lavenir I, Ozcelik S, Tolnay M, Winkler DT and Goedert M (2012) Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy. Brain 135, 2169-2177 https://doi.org/10.1093/brain/aws143
- Ozcelik S, Fraser G, Castets P et al (2013) Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice. PLoS One 8, e62459 https://doi.org/10.1371/journal.pone.0062459
- Shimada K, Motoi Y, Ishiguro K et al (2012) Long-term oral lithium treatment attenuates motor disturbance in tauopathy model mice: implications of autophagy promotion. Neurobiol Dis 46, 101-108 https://doi.org/10.1016/j.nbd.2011.12.050
- Lees AJ, Hardy J and Revesz T. Parkinson's disease. Lancet (London, England) 373, 2055-2066 https://doi.org/10.1016/S0140-6736(09)60492-X
- Sveinbjornsdottir S (2016) The clinical symptoms of Parkinson's disease. J Neurochem 139, 318-324 https://doi.org/10.1111/jnc.13691
- Martin I, Dawson VL and Dawson TM (2011) Recent advances in the genetics of Parkinson's disease. Annu Rev Genomics Hum Genet 12, 301-325 https://doi.org/10.1146/annurev-genom-082410-101440
- Goedert M, Spillantini MG, Del Tredici K and Braak H (2013) 100 years of Lewy pathology. Nat Rev Neurol 9, 13-24 https://doi.org/10.1038/nrrheum.2012.143
- Winslow AR, Chen C-W, Corrochano S et al (2010) alpha-Synuclein impairs macroautophagy: implications for Parkinson's disease. J Cell Biol 190, 1023-1037 https://doi.org/10.1083/jcb.201003122
- Williams A, Sarkar S, Cuddon P et al (2008) Novel targets for Huntington's disease in an mTORindependent autophagy pathway. Nat Chem Biol 4, 295-305 https://doi.org/10.1038/nchembio.79
- Decressac M, Mattsson B, Weikop P, Lundblad M, Jakobsson J and Bjorklund A (2013) TFEB-mediated autophagy rescues midbrain dopamine neurons from alpha-synuclein toxicity. Proc Natl Acad Sci U S A 110, E1817-1826 https://doi.org/10.1073/pnas.1305623110
- Kahle PJ (2008) alpha-Synucleinopathy models and human neuropathology: similarities and differences. Acta Neuropathol 115, 87-95
- Rubinsztein DC, Codogno P and Levine B (2012) Autophagy modulation as a potential therapeutic target for diverse diseases. Nat Rev Drug Discov 11, 709-730 https://doi.org/10.1038/nrd3802
- Maiese K, Chong ZZ, Shang YC and Wang S (2013) mTOR: on target for novel therapeutic strategies in the nervous system. Trends Mol Med 19, 51-60 https://doi.org/10.1016/j.molmed.2012.11.001
- Webb JL, Ravikumar B, Atkins J, Skepper JN and Rubinsztein DC (2003) Alpha-Synuclein is degraded by both autophagy and the proteasome. J Biol Chem 278, 25009-25013 https://doi.org/10.1074/jbc.M300227200
- Crews L, Spencer B, Desplats P et al (2010) Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy. PLoS One 5, e9313 https://doi.org/10.1371/journal.pone.0009313
- Pan T, Rawal P, Wu Y, Xie W, Jankovic J and Le W (2009) Rapamycin protects against rotenone-induced apoptosis through autophagy induction. Neuroscience 164, 541-551 https://doi.org/10.1016/j.neuroscience.2009.08.014
- Malagelada C, Jin ZH, Jackson-Lewis V, Przedborski S and Greene LA (2010) Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease. J Neurosci 30, 1166-1175 https://doi.org/10.1523/JNEUROSCI.3944-09.2010
- Bai X, Wey MC-Y, Fernandez E et al (2015) Rapamycin improves motor function, reduces 4-hydroxynonenal adducted protein in brain, and attenuates synaptic injury in a mouse model of synucleinopathy. Pathobiol Aging Age Relat Dis 5, 28743 https://doi.org/10.3402/pba.v5.28743
- Tain LS, Mortiboys H, Tao RN, Ziviani E, Bandmann O and Whitworth AJ (2009) Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss. Nat Neurosci 12, 1129-1135 https://doi.org/10.1038/nn.2372
- Bove J, Martinez-Vicente M and Vila M (2011) Fighting neurodegeneration with rapamycin: mechanistic insights. Nat Rev Neurosci 12, 437-452 https://doi.org/10.1038/nrn3068
- Forlenza O V, De-Paula VJR and Diniz BSO (2014) Neuroprotective effects of lithium: implications for the treatment of Alzheimer's disease and related neurodegenerative disorders. ACS Chem Neurosci 5, 443-450 https://doi.org/10.1021/cn5000309
- Sarkar S, Floto RA, Berger Z et al (2005) Lithium induces autophagy by inhibiting inositol monophosphatase. J Cell Biol 170, 1101-1111 https://doi.org/10.1083/jcb.200504035
- Hou L, Xiong N, Liu L et al (2015) Lithium protects dopaminergic cells from rotenone toxicity via autophagy enhancement. BMC Neurosci 16, 82 https://doi.org/10.1186/s12868-015-0222-y
- Chao T-K, Hu J and Pringsheim T (2017) Risk factors for the onset and progression of Huntington disease. Neurotoxicology 2130, 21
- Fan H-C, Ho L-I, Chi C-S et al (2014) Polyglutamine (PolyQ) diseases: genetics to treatments. Cell Transplant 23, 441-458 https://doi.org/10.3727/096368914X678454
- Jiang W, Wei W, Gaertig MA, Li S and Li X-J (2015) Therapeutic Effect of Berberine on Huntington's Disease Transgenic Mouse Model. PLoS One 10, e0134142 https://doi.org/10.1371/journal.pone.0134142
- Wu A-G, Wong VK-W, Xu S-W et al (2013) Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant alpha-synuclein and huntingtin in PC-12 cells. Int J Mol Sci 14, 22618-22641 https://doi.org/10.3390/ijms141122618
- Sun Y-M, Lu C and Wu Z-Y (2016) Spinocerebellar ataxia: relationship between phenotype and genotype - a review. Clin Genet 90, 305-314 https://doi.org/10.1111/cge.12808
- Menzies FM, Huebener J, Renna M, Bonin M, Riess O and Rubinsztein DC (2010) Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3. Brain 133, 93-104 https://doi.org/10.1093/brain/awp292
- Lin C-H, Wu Y-R, Yang J-M et al (2016) Novel Lactulose and Melibiose Targeting Autophagy to Reduce PolyQ Aggregation in Cell Models of Spinocerebellar Ataxia 3. CNS Neurol Disord Drug Targets 15, 351 https://doi.org/10.2174/1871527314666150821101522
- Zarei S, Carr K, Reiley L et al (2015) A comprehensive review of amyotrophic lateral sclerosis. Surg Neurol Int 6, 171 https://doi.org/10.4103/2152-7806.169561
- Morimoto N, Nagai M, Ohta Y et al (2007) Increased autophagy in transgenic mice with a G93A mutant SOD1 gene. Brain Res 1167, 112-117 https://doi.org/10.1016/j.brainres.2007.06.045
- Gal J, Strom A-L, Kwinter DM et al (2009) Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism. J Neurochem 111, 1062-1073 https://doi.org/10.1111/j.1471-4159.2009.06388.x
- Castillo K, Nassif M, Valenzuela V et al (2013) Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons. Autophagy 9, 1308-1320 https://doi.org/10.4161/auto.25188
- Frake RA, Ricketts T, Menzies FM and Rubinsztein DC (2015) Autophagy and neurodegeneration. J Clin Invest 125, 65-74 https://doi.org/10.1172/JCI73944
- Moreau K, Fleming A, Imarisio S et al (2014) PICALM modulates autophagy activity and tau accumulation. Nat Commun 5, 4998 https://doi.org/10.1038/ncomms5998
- Benjamin D, Colombi M, Moroni C and Hall MN (2011) Rapamycin passes the torch: a new generation of mTOR inhibitors. Nat Rev Drug Discov 10, 868-880 https://doi.org/10.1038/nrd3531
- Choi H, Kim HJ, Kim J et al (2017) Increased acetylation of Peroxiredoxin1 by HDAC6 inhibition leads to recovery of Abeta-induced impaired axonal transport. Mol Neurodegener 12, 23 https://doi.org/10.1186/s13024-017-0164-1
- Cha M-Y, Kwon Y-W, Ahn H-S et al (2017) Protein-Induced Pluripotent Stem Cells Ameliorate Cognitive Dysfunction and Reduce Abeta Deposition in a Mouse Model of Alzheimer's Disease. Stem Cells Transl Med 6, 293-305 https://doi.org/10.5966/sctm.2016-0081
- Son SM, Cha M-Y, Choi H et al (2016) Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease. Autophagy 12, 784-800 https://doi.org/10.1080/15548627.2016.1159375
- Son SM, Kang S, Choi H and Mook-Jung I (2015) Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway. Mol Neurodegener 10, 56 https://doi.org/10.1186/s13024-015-0054-3
- Huang L, Luo Y, Pu Z et al (2017) Oxoisoaporphine alkaloid derivative 8-1 reduces Abeta1- 42 secretion and toxicity in human cell and Caenorhabditis elegans models of Alzheimer's disease. Neurochem Int 108, 157-168 https://doi.org/10.1016/j.neuint.2017.03.007
- Huang M, Jiang X, Liang Y, Liu Q, Chen S and Guo Y (2017) Berberine improves cognitive impairment by promoting autophagic clearance and inhibiting production of beta-amyloid in APP/tau/PS1 mouse model of Alzheimer's disease. Exp Gerontol 91, 25-33 https://doi.org/10.1016/j.exger.2017.02.004
- Jiang T-F, Zhang Y-J, Zhou H-Y et al (2013) Curcumin ameliorates the neurodegenerative pathology in A53T alpha-synuclein cell model of Parkinson's disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy. J Neuroimmune Pharmacol 8, 356-369 https://doi.org/10.1007/s11481-012-9431-7
- Rahman MA, Bishayee K, Sadra A and Huh S-O (2017) Oxyresveratrol activates parallel apoptotic and autophagic cell death pathways in neuroblastoma cells. Biochim Biophys Acta 1861, 23-36 https://doi.org/10.1016/j.bbagen.2016.10.025
- Rahman MA, Bishayee K, Habib K, Sadra A and Huh S-O (2016) 18alpha-Glycyrrhetinic acid lethality for neuroblastoma cells via de-regulating the Beclin-1/Bcl-2 complex and inducing apoptosis. Biochem Pharmacol 117, 97-112 https://doi.org/10.1016/j.bcp.2016.08.006
- Bernard A, Jin M, Xu Z and Klionsky DJ (2015) A large-scale analysis of autophagy-related gene expression identifies new regulators of autophagy. Autophagy 11, 2114-2122 https://doi.org/10.1080/15548627.2015.1099796
Cited by
- Cellular and molecular mechanisms involved in the resolution of innate leukocyte inflammation vol.104, pp.3, 2018, https://doi.org/10.1002/JLB.3MA0218-070R
- Autophagy vol.24, pp.2, 2018, https://doi.org/10.1097/MCC.0000000000000486
- Recent Advances in Studies on the Therapeutic Potential of Dietary Carotenoids in Neurodegenerative Diseases vol.2018, pp.1942-0994, 2018, https://doi.org/10.1155/2018/4120458
- 11β-HSD1 Inhibition by RL-118 Promotes Autophagy and Correlates with Reduced Oxidative Stress and Inflammation, Enhancing Cognitive Performance in SAMP8 Mouse Model pp.1559-1182, 2018, https://doi.org/10.1007/s12035-018-1026-8
- mTOR: A Cellular Regulator Interface in Health and Disease vol.8, pp.1, 2019, https://doi.org/10.3390/cells8010018