The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
권호 표지
DOI QR코드

DOI QR Code

Five Cases of Severe Alopecia Areata Treated with Gagamhwajung-hwan

가감화중환으로 호전된 중증 원형탈모 치험 5례

  • Received : 2017.06.27
  • Accepted : 2017.08.02
  • Published : 2017.08.25
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : The purpose of this study is to report the effectiveness of Gagamhwajung-hwan in five severe alopecia areata patients. Methods : This case study was conducted for five severe alopecia areata patients who visited Korean Medicine Clinic. Herbal medicine(Gagamhwajung-hwan) was prescribed to all five patients. Improvements of patients were evaluated by photographs and SALT(Severity of alopecia tool) scale. Results : According to photographs, hair loss of each patient was completely improved. SALT scale was also decreased in all five patients. Conclusions : This study shows the possibility of using Gagamhwajung-hwan to treat severe alopecia areata.

Keywords

References

  1. Koran Dermatology Association. Textbook of Dermatology. 6th ed. Seoul:Med book. 2014:551-7.
  2. Lee SG, Shin JH, Choi GS. Therapeutic Effect of Topical Diphenylcyclopropenone (DPCP) for the Treatment of Extensive Alopecia areata. Korean J Dermatol. 2004;42(9):1130-7.
  3. The Text Compilation Committee of Korean Dermatological Association. Dermatology. 4th ed. Seoul:Yeomoongak. 2001:479.
  4. Korean statistical information service[cited 2017 March 16]. Available from: [URL] http://kosis.kr/statisticsList/statisticsList_01List.jsp?vwcd=MT_ZTITLE&parentId=D#SubCon.
  5. Mandani S, Shapiro J. Alopecia areata update. J Am Acad Dermatol. 2000;42:549-66. https://doi.org/10.1067/mjd.2000.103909
  6. Sowonbang. Jebyeongwonhurongkyoju. Beijing:Inminwisaeng pub. 1983:761-9.
  7. Kim JS, Park SY. A Case of Alopecia areata treated with Korean Medical Treatment. Herbal Formula Science. 2016;24(2):124-30. https://doi.org/10.14374/HFS.2016.24.2.124
  8. Jeong IK, Jo HY, Kim TH, Kim NS, Jeong HS, Lee CH. Experimental Studies on the Hair Growth Activity of Extracts of Pinelliae Rhizoma in Spontaneous Alopecia Model and Normal C57BL/6N Mice. Korean Society of Oriental Pathology. 2009;23(1):84-92.
  9. Olsen EA, Hordinsky MK, Prince VH, Roberts JL, Shapiro J, Canfield D, et al. Alopecia areata investigational assessment guidelines-Part II. Journal of the American Academy of Dermatology. 2004;51(3):440-7. https://doi.org/10.1016/j.jaad.2003.09.032
  10. Ahn SG, Jang KH, Song JW, Cheon SH. Common Skin Disease. 2nd ed. Seoul:Doctor's Book. 2009:496-8.
  11. Chong JH, Ihm CW. Clinical study for Alopecia Areata in Children under 12 Years Old. Korean J Dermatol. 2002;40(7):759-65.
  12. Dermatology class of Seoul univ. Dermatology. 3rd ed. Seoul:Korea medical P. 2011:262-3.
  13. Dawber R, Neste D. Hair and Scalp Disorders - Common Presenting Signs, Differentrial Diagnosis and Treatment. 2nd ed. Seoul:Koonja. 2005:279,287,290.
  14. Gilhar A, Etzioni A, Paus R. Alopecia areata. New England Journal of Medicine. 2012;366(16):1515-25. https://doi.org/10.1056/NEJMra1103442
  15. Carroll, J, McElwee KJ, King LE, Byrne M, Sundberg JP. Gene array profiling and immunomodulation studies define a cell mediated immune response underlying the pathogenesis of alopecia areata in a mouse model and humans. J Invest Dermatol. 2002;119(2):392-402. https://doi.org/10.1046/j.1523-1747.2002.01811.x
  16. Paus R, Link RE. The psoriatic epidermal lesion and anagen hair growth may share the same "switch-on" mechanism. Yale J Biol Med. 1989;61:467-76.
  17. Kozlowska U, Blume-Peytavi U, Kodelja V, Sommer C, Goerdt S, Majewski S, et al. Expression of vascular endothelial growth factor (VEGF) in various compartments of the human follicle. Arch Dermatol Res. 1998;290:661-8. https://doi.org/10.1007/s004030050370
  18. Kang H. Recent Advances in Alopecia Areata. Program book of Korea J Dermatol. 2009;61(2):109-10.
  19. Lee SH, Cho MR. A Philological Study on the Pathology, Acupuncture and Moxibustion of Alopecia. The Acupuncture. 2015;32(2):35-57. https://doi.org/10.13045/acupunct.2015018
  20. The Textbook Compilation Committee of the Traditional Korean Dermatology & Surgery Society. Text of Traditional Korean Dermatology & Surgery. Busan:Sunwo Publishing Company. 2007:508-11.
  21. Arnold HL, Odom RB, James WD. Andrew's diseases of the skin. 8th ed. Philadelphia:WB Saunders Co. 1990:879-82.
  22. Lee YH. Clinical and Descriptive Epidemiological Study of Alopecia Areata. Graduate School of Wonkwang University. 2008.
  23. Happel R, Hausen BJ, Wiesner-Menzel L. Diphencyprone in the treatment of alopecia areata. Acta Derm Venereol. 1983;63:49-52.
  24. In SK, Shin JH, Choi GS. Therapeutic Effect of Topical Diphenylcyclopropenone(DPCP) for the Treatment of Extensive Alopecia areata. Department of Dermatology, College of Medicine, Inha University. 2004.
  25. Lee JC, Kim HY, Kim HJ, Kim BS, Lee WJ, Lee SJ, et al. Long Term Follow-Up Study of Corticosteroid-Treated Patients with Alopecia Areata. Korean J Dermatol. 2008;46(4):465-72.
  26. Lee SW, Ko JM, Lee SY, Lee MH, Kim YJ, Lee SH, et al. A Case Study of Beevenom Effect on Alopecia Universalis Started from Alopecia Areata. The Journal of Korean Acupuncture & Moxibustion Society. 2008;25(6):163-73.
  27. HwangBo M, Jeong MJ, Seo HS. A Case Report of Child with Alopecia Areata. The Journal of Pediatrics of Korean Medicine. 2012;26(2):47-52. https://doi.org/10.7778/jpkm.2012.26.2.047
  28. Cho AR, Hong SE. A Case Report of Alopecia Treated by Gagamsunbangpaedok-tang (Jiajianxianfangbaidu-tang)-Focused on Multi-patched Alopecia Areata with Lymphadenopathy. J Kor Med Opthalmol Otolaryngol Dermatol. 2014;27(1):130-9. https://doi.org/10.6114/jkood.2014.27.1.130
  29. Kim CY, Seo HS, Lee DJ, Kwan K. Case Study on Treating Scarring Alopecia and Alopecia Areata Using Low Level Laser Therapy and Acupuncture. J Kor Med Opthalmol Otolaryngol Dermatol. 2016;29(4):182-8. https://doi.org/10.6114/jkood.2016.29.4.182
  30. Yoon HJ. A Case Study of Androgenetic Alopecia in Woman Improved by Pharmacopuncture Therapy and Needleembedding Therapy. J Kor Med Opthalmol Otolaryngol Dermatol. 2014;27(3):162-70. https://doi.org/10.6114/jkood.2014.27.3.162
  31. Lee, JH, Kang YR, Jeong YH, Ahn TW. A Case of Extensive Alopecia Areata Treated with Traditional Oriental Hair Care Products. J Kor Med Opthalmol Otolaryngol Dermatol. 2009;22(2):269-80.